Browsing by Departments "A.I. Virtanen -instituutti"
Now showing items 21-40 of 375
-
Age- and quality-dependent DNA methylation correlate with melanin-based coloration in a wild bird
(Wiley, 2018)Secondary sexual trait expression can be influenced by fixed individual factors (such as genetic quality) as well as by dynamic factors (such as age and environmentally induced gene expression) that may be associated with ...Tieteelliset aikakauslehtiartikkelit
-
Age-Dependent, Subunit Specific Action of Hydrogen Sulfide on GluN1/2A and GluN1/2B NMDA Receptors
(Frontiers Media SA, 2017)Hydrogen sulfide (H2S) is an endogenously produced neuroactive gas implicated in many key processes in the peripheral and central nervous system. Whereas the neuroprotective role of H2S has been shown in adult brain, the ...info:eu-repo/semantics/article
-
Aggravated post-infarct heart failure in type 2 diabetes is associated with impaired mitophagy and exaggerated inflammasome activation
(Elsevier BV, 2017)Type 2 diabetes mellitus (T2DM) is a major risk factor for heart disease. Mortality rates after myocardial infarction (MI)are significantly increased in T2DM patients because of dysfunctional left ventricle (LV). However, ...info:eu-repo/semantics/article
-
Alcohol consumption during adolescence is associated with reduced grey matter volumes
(Wiley-Blackwell, 2017)Background and aims Cognitive impairment has been associated with excessive alcohol use, but its neural basis is poorly understood. Chronic excessive alcohol use in adolescence may lead to neuronal loss and volumetric ...Tieteelliset aikakauslehtiartikkelit
-
Algorithm for automatic detection of spontaneous seizures in rats with post-traumatic epilepsy
(Elsevier BV, 2018)Background Labor intensive electroencephalogram (EEG) analysis is a major bottleneck to identifying anti-epileptogenic treatments in experimental models of post-traumatic epilepsy. We aimed to develop an algorithm for ...Tieteelliset aikakauslehtiartikkelit
-
Aluminum fluoride-18 labeled folate enables in vivo detection of atherosclerotic plaque inflammation by positron emission tomography
(Springer Nature, 2018)Inflammation plays an important role in the development of atherosclerosis and its complications. Because the folate receptor β (FR-β) is selectively expressed on macrophages, an FR targeted imaging agent could be useful ...Tieteelliset aikakauslehtiartikkelit
-
Alzheimer's Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes
(Springer Nature, 2019)Purpose The study aim was to evaluate the effect of Alzheimer’s disease (AD) and inflammatory insult on the function of L-type amino acid transporter 1 (Lat1) at the mouse blood-brain barrier (BBB) as well as Lat1 function ...Tieteelliset aikakauslehtiartikkelit
-
Alzheimerin taudin amyloidikuormaa vähentävät lääkkeet käännekohdassa
(Suomalainen lääkäriseura Duodecim, 2020)Keskeisenä keinona Alzheimerin taudin prosessin pysäyttämiseksi pidetään aivojen amyloidikuorman vähentämistä. Siihen on pyritty immunisaatiolla ja beeta-amyloidi (Aβ) -peptidin muodostumista estävillä pienimolekyylisillä ...Tieteelliset aikakauslehtiartikkelit
-
Amphiphilic Phthalocyanines in Polymeric Micelles: A Supramolecular Approach toward Efficient Third-Generation Photosensitizers
(Royal Society of Chemistry (RSC), 2020)In this paper we describe a straightforward supramolecular strategy to encapsulate silicon phthalocyanine (SiPc) photosensitizers (PS) in polymeric micelles made of poly(ε-caprolactone)-b-methoxypoly(ethylene glycol) ...Tieteelliset aikakauslehtiartikkelit
-
An improved lentivirus vector for safer transgene integration and protein transduction
(Itä-Suomen yliopisto; University of Eastern Finland, 2013)info:eu-repo/semantics/doctoralThesis
-
Analysis of primary microRNA loci from nascent transcriptomes reveals regulatory domains governed by chromatin architecture
(Oxford University Press (OUP), 2017)Changes in mature microRNA (miRNA) levels that occur downstream of signaling cascades play an important role during human development and disease. However, the regulation of primary microRNA (pri-miRNA) genes remains to ...info:eu-repo/semantics/article
-
Analytic Tools for Post-traumatic Epileptogenesis Biomarker Search in Multimodal Dataset of an Animal Model and Human Patients
(Frontiers Media SA, 2018)Epilepsy is among the most common serious disabling disorders of the brain, and the global burden of epilepsy exerts a tremendous cost to society. Most people with epilepsy have acquired forms of the disorder, and the ...Tieteelliset aikakauslehtiartikkelit
-
Angiogenic gene therapy in cardiovascular diseases: dream or vision?
(Oxford University Press (OUP), 2017)Chronic cardiovascular diseases are significant health problems. Although current treatment strategies have tremendously improved disease management, up to 30% of these patients cannot be successfully treated with current ...info:eu-repo/semantics/article
-
Animal models for anti-angiogenic therapy of malignant glioma
(Itä-Suomen yliopisto; University of Eastern Finland, 2012)info:eu-repo/semantics/doctoralThesis
-
Applications of Sweep Imaging with Fourier Transformation (SWIFT) : imaging brain microstructure and calcifications
(Itä-Suomen yliopisto; University of Eastern Finland, 2016)info:eu-repo/semantics/doctoralThesis
-
Assessment of Health Risks of Intermediate Frequency Magnetic Fields
(Springer Singapore, 2017)Health effects of electromagnetic fields have been studied mainly focusing on extremely low frequency magnetic fields and radio frequency fields. Less attention has been paid to intermediate frequency magnetic fields (IF ...info:eu-repo/semantics/bookPart
-
Assessment of the effects of different sample perfusion procedures on phase-contrast tomographic images of mouse spinal cord
(IOP Publishing, 2018)Synchrotron X-ray Phase Contrast micro-Tomography (SXrPCμT) is a powerful tool in the investigation of biological tissues, including the central nervous system (CNS), and it allows to simultaneously detect the vascular and ...Tieteelliset aikakauslehtiartikkelit
-
Astrocyte Progenitors Derived From Patients With Alzheimer Disease Do Not Impair Stroke Recovery in Mice
(American Heart Association, 2022)BACKGROUND: Species-specific differences in astrocytes and their Alzheimer disease-associated pathology may influence cellular responses to other insults. Herein, human glial chimeric mice were generated to evaluate how ...
-
Astrocyte-Mediated Neuronal Synchronization Properties Revealed by False Gliotransmitter Release
(Society for Neuroscience, 2017)Astrocytes spontaneously release glutamate (Glut) as a gliotransmitter (GT), resulting in the generation of extrasynaptic NMDAR-mediated slow inward currents (SICs) in neighboring neurons, which can increase local neuronal ...info:eu-repo/semantics/article
-
Astrosyytit Alzheimerin taudissa ja tautimalli humanisoiduilla hiirillä
(Itä-Suomen yliopisto; University of Eastern Finland, 2016)info:eu-repo/semantics/masterThesis