Browsing by Title
Now showing items 1758-1777 of 2265
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Safety, tolerability and efficacy of the glutaminyl cyclase inhibitor PQ912 in Alzheimer's disease: results of a randomized, double-blind, placebo-controlled phase 2a stud
(Springer Nature America, Inc, 2018)Background PQ912 is an inhibitor of the glutaminyl cyclase enzyme that plays a central role in the formation of synaptotoxic pyroglutamate-A-beta oligomers. We report on the first clinical study with PQ912 in subjects ... -
Saliva and serum biomarkers in periodontitis and coronary artery disease
(WileyTanska, 2018)Aim Matrix metalloproteinase (MMP)‐8, MMP‐9, tissue inhibitor of matrix metalloproteinase (TIMP)‐1 and myeloperoxidase (MPO) participate in extracellular matrix breakdown both in periodontium and atherosclerotic plaques. ... -
Salivary biomarkers in association with periodontal parameters and the periodontitis risk haplotype
(SAGE Publications, 2018)Genetic factors play a role in periodontitis. Here we examined whether the risk haplotype of MHC class III region BAT1-NFKBIL1-LTA and lymphotoxin-α polymorphisms associate with salivary biomarkers of periodontal disease. ... -
SALSA2.0: The sectional aerosol module of the aerosol-chemistry-climate model ECHAM6.3.0-HAM2.3-MOZ1.0
(Copernicus GmbHSaksa, 2018)In this paper, we present the implementation and evaluation of the aerosol microphysics module SALSA2.0 in the framework of the aerosol–chemistry–climate model ECHAM-HAMMOZ. It is an alternative microphysics module to the ... -
Sanomisen vaikeus ja välttämättömyys
(AVAIN - Kirjallisuudentutkimuksen aikakauslehtiSuomi, 2018)Humanistinen tutkimus ja erityisesti kirjallisuudentutkimus ovat aitiopaikalla, kun tarkastellaan muutoksia ihmisten tavoissa hahmottaa suhdettaan ympäristöön, yhteiskuntaan ja ylipäätään siihen mitä milloinkin kutsutaan ... -
Sarcoplasmic reticulum Ca2+ -induced Ca2+ release regulates class IIa HDAC localization in mouse embryonic cardiomyocytes
(Wiley-Blackwell, 2018)In embryonic cardiomyocytes, sarcoplasmic reticulum (SR)‐derived Ca2+ release is required to induce Ca2+ oscillations for contraction and to control cardiac development through Ca2+‐activated pathways. Here, our aim was ... -
Satellite tracking of red-listed nominate lesser black-backed gulls Larus f. fuscus: habitat specialisation in foraging movements raises novel conservation needs
(Elsevier BV, 2017)In contrast to many other gull species, nominate lesser black-backed gulls (Larus fuscus fuscus, nLBBG) have shown generally decreasing population trends throughout their breeding area in northern and eastern Fennoscandia ... -
Sauna bathing is associated with reduced cardiovascular mortality and improves risk prediction in men and women: a prospective cohort study
(Springer Nature America, Inc, 2018)Background Previous evidence indicates that sauna bathing is related to a reduced risk of fatal cardiovascular disease (CVD) events in men. The aim of this study was to investigate the relationship between sauna habits ... -
Sähköiset terveyspalvelut osaksi potilaan arkea
(Finnish Journal of eHealth and eWelfareSuomi, 2019)Studies recently showed that interest in electronic healthcare services has increased, and there is a need to guide and inform patients and their families about the formats of such services. The purposes of this study were ... -
Scalable fabrication of the graphitic substrates for graphene-enhanced Raman spectroscopy
(Springer Nature, 2017)We propose direct synthesis of ultra-thin graphitic films on a dielectric substrate using sacrificial Ni catalyst layer, which significantly increases the crystallinity of the photoresist pyrolyzed at the temperature of ... -
Scalable Synthesis of Biodegradable Black Mesoporous Silicon Nanoparticles for Highly Efficient Photothermal Therapy
(American Chemical Society (ACS), 2018)Porous silicon (PSi) has attracted wide interest as a potential material for various fields of nanomedicine. However, until now, the application of PSi in photothermal therapy has not been successful due to its low ... -
Scanning of skin gloss by a diffractive optical element-based handheld glossmeter
(Springer Nature America, IncJapani, 2018)Skin specular gloss (referred to as “gloss’’) determination is important in dermatology and cosmetic industry as it gives an indication of the skin health and beauty. Its accurate determination is, therefore, necessary. ... -
Scattering of partially coherent surface plasmon polariton fields by metallic nanostripe
(Springer Nature, 2019)Background Surface plasmon polaritons (SPPs) are electromagnetic waves that propagate at a metal-dielectric interface. Until recently, monochromatic, fully coherent SPPs have mainly been considered. Methods We investigate ... -
Scenario analyses for the effects of harvesting intensity on development of forest resources, timber supply, carbon balance and biodiversity of Finnish forestry
(Elsevier BV, 2017)We used national scenario analyses to examine the effects of harvesting intensity on the development of forest resources, timber supply, carbon balance, and biodiversity indicators of Finnish forestry in nine 10-year ... -
Scenario analyses on the effects of fertilization, improved regeneration material, and ditch network maintenance on timber production of Finnish forests
(Springer Nature, 2017)We used national scenario analyses to examine the effects of fertilization, use of improved regeneration material and ditch network maintenance (DNM), both separately and simultaneously, on timber production of Finnish ... -
Scenario Evaluation with Relevance and Interest (SERI): Development and Validation of a Scenario Measurement Tool for Context-Based Learning
(Springer Nature America, IncAlankomaat, 2018)Context-based learning (CBL) approaches have been recommended and expanded in science education to make science more relevant to students by connecting science content with students’ daily life. Subsequently, in order to ... -
A scheme for a flexible classification of dietary and health biomarkers
(Springer Nature, 2018)Biomarkers are an efficient means to examine intakes or exposures and their biological effects and to assess system susceptibility. Aided by novel profiling technologies, the biomarker research field is undergoing rapid ... -
Schizophonia
(2019) -
Scots pine provenance affects the emission rate and chemical composition of volatile organic compounds of forest floor
(Canadian Science PublishingKanada, 2018)Scots pine (Pinus sylvestris L.) is an important source of biogenic volatile organic compounds (BVOCs) in the boreal zone. BVOC emission rate and profile affect air quality, climate forcing, plant stress tolerance, and ... -
SDF1 gradient associates with the distribution of c-Kit+ cardiac cells in the heart
(Springer Nature, 2018)Identification of the adult cardiac stem cells (CSCs) has offered new therapeutic possibilities for treating ischemic myocardium. CSCs positive for the cell surface antigen c-Kit are known as the primary source for cardiac ...
