Browsing by Author "A.I. Virtanen -instituutti"
Now showing items 1-20 of 398
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3D human brain cell models: New frontiers in disease understanding and drug discovery for neurodegenerative diseases
(Elsevier BV, 2018)Neurodegenerative disorders have an enormous impact on society and healthcare budgets. There has been a high degree of failure in many recent clinical trials for disease-modifying therapeutics. A major factor in this failure ...Tieteelliset aikakauslehtiartikkelit
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5-hydroxytryptamine in migraine: the puzzling role of ionotropic 5-HT3 receptor in the context of established therapeutic effect of metabotropic 5-HT1 subtypes
(Wiley, 2021)5-hydroxytryptamine (5-HT; serotonin) is traditionally considered as a key mediator implicated in migraine. Multiple 5-HT receptor subtypes contribute to a variety of region-specific functional effects. The raphé nuclei ...Tieteelliset aikakauslehtiartikkelit
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A multiscale imaging approach to assess brain damage in rats
(Itä-Suomen yliopisto; University of Eastern Finland, 2023)info:eu-repo/semantics/doctoralThesis
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A Novel Genetic Marker for the C9orf72 Repeat Expansion in the Finnish Population
(IOS Press, 2021)Background: C9orf72 repeat expansion (C9exp) is the most common genetic cause underlying frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). However, detection of the C9exp requires elaborative ...Tieteelliset aikakauslehtiartikkelit
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A report from the 8th Kuopio Alzheimer Symposium
(Future Medicine Ltd, 2018)The international Kuopio Alzheimer Symposium was organized by the University of Eastern Finland in Kuopio, Finland on June 6–8, 2018 for the 8th time. Approximately 300 researchers in the fields of neuroscience and neurology ...Tieteelliset aikakauslehtiartikkelit
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A study of rodent brain function with functional and pharmacological magnetic resonance imaging
(Itä-Suomen yliopisto; University of Eastern Finland, 2013)info:eu-repo/semantics/doctoralThesis
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A systems biology approach for identification and stepwise validation of pharmacotherapy candidates for traumatic brain injury
(Itä-Suomen yliopisto; University of Eastern Finland, 2020)info:eu-repo/semantics/doctoralThesis
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A web-based application for generating 2D-unfolded cortical maps to analyze the location and extent of cortical lesions following traumatic brain injury in adult rats
(Elsevier BV, 2018)Background Both the type and severity of functional impairments caused by damage to the cerebral cortex depend on the functional cortical areas and networks affected, as well as the lesion extent and type. New method To ...Tieteelliset aikakauslehtiartikkelit
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Activating the Chromatin by Noncoding RNAs
(Mary Ann Liebert Inc, 2017)Significance: The extent and breadth of transcription have recently been uncovered and this has revealed an extensive array of noncoding RNAs (ncRNAs). The biological role and significance of these ncRNAs have been realized ...info:eu-repo/semantics/article
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Acute downregulation of novel hypothalamic protein sushi repeat-containing protein X-Linked 2 (SRPX2) after experimental traumatic brain injury
(Mary Ann Liebert Inc, 2019)Traumatic brain injury (TBI) causes damage to the hypothalamo-hypophyseal axis, leading to endocrine dysregulation in up to 40% of TBI patients. Hence, there is an urgent need to identify non-invasive biomarkers for ...Tieteelliset aikakauslehtiartikkelit
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Acute non-convulsive status epilepticus after experimental traumatic brain injury in rats
(Mary Ann Liebert Inc, 2019)Severe traumatic brain injury (TBI) induces seizures or status epilepticus (SE) in 20–30% of patients during the acutephase. We hypothesized that severe TBI induced with lateral fluid-percussion injury (FPI) triggers ...Tieteelliset aikakauslehtiartikkelit
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Adenosine promotes endplate nAChR channel activity in adult mouse skeletal muscle fibres via low affinity P1 receptors
(Elsevier BV, 2018)Adenosine is a powerful modulator of skeletal neuromuscular transmission, operating via inhibitory or facilitatory purinergic-type P1 receptors. To date, studies have been focused mainly on the effect of adenosine on ...Tieteelliset aikakauslehtiartikkelit
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Adenoviral gene therapy for the stimulation of neovessel growth : new treatment strategies for lymphedema and peripheral ischemia
(Itä-Suomen yliopisto; University of Eastern Finland, 2015)info:eu-repo/semantics/doctoralThesis
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Adenoviral gene transfer of Gremlin modulates VEGF-A induced angiogenesis in porcine myocardium
(Mary Ann Liebert Inc, 2020)Coronary artery disease is a major cause of death and disability worldwide. New therapies are needed for patients who do not benefit or are not suitable for current treatments. Angiogenic gene therapy using vascular ...Tieteelliset aikakauslehtiartikkelit
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Adenoviral intramyocardial VEGF-DdeltaNdeltaC gene transfer increases myocardial perfusion reserve in refractory angina patients: a phase I/IIa study with 1-year follow-up
(Oxford University Press (OUP), 2017)Aims We evaluated for the first time the effects of angiogenic and lymphangiogenic AdVEGF-DΔNΔC gene therapy in patients with refractory angina. Methods and results Thirty patients were randomized to AdVEGF-DΔNΔC ...info:eu-repo/semantics/article
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Adenovirus and baculovirus mediated proangiogenic gene therapy in skeletal muscle and uterine artery : safety aspects in peripheral arterial disease and fetal growth restriction therapy
(Itä-Suomen yliopisto; University of Eastern Finland, 2013)info:eu-repo/semantics/doctoralThesis
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Advanced microscopic validation of diffusion MRI in rat brain
(Itä-Suomen yliopisto; University of Eastern Finland, 2021)info:eu-repo/semantics/doctoralThesis
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Advanced MRI approaches for characterization of tissue microstructural changes in experimental traumatic brain injury
(Itä-Suomen yliopisto; University of Eastern Finland, 2023)info:eu-repo/semantics/doctoralThesis
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AdVEGF-D(ANAC)-geeninsiirto sian sydäninfarktimallissa, angiogeneesi ja lymfangiogeneesi
(Itä-Suomen yliopisto; University of Eastern Finland, 2013)info:eu-repo/semantics/masterThesis
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Afatinibi -lääkeaine laskimoverisuoniepämuodostuman kasvun estäjänä
(Itä-Suomen yliopisto; University of Eastern Finland, 2023)info:eu-repo/semantics/masterThesis
