Now showing items 1-5 of 5

    • Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome 

      Piippo, N; Korhonen, E; Hytti, M; Skottman, H; Kinnunen, K; Josifovska, N; Petrovski, G; Kaarniranta, K; Kauppinen, A (Springer Nature, 2018)
      Once activated, the intracellular receptor NLRP3 assembles an inflammasome protein complex that facilitates the caspase-1-mediated maturation of IL-1β and IL-18. Inactive NLRP3 is guarded by a protein complex containing ...
    • Molecular Mechanisms Underlying Age-Related Ocular Diseases 

      Amadio, M; Kaarniranta, K; Xu, H; Smedowski, A; Ferrington, DA (Hindawi Limited, 2018)
    • Suppressed heat shock protein response in the kidney of exercise-trained diabetic rats 

      Lappalainen, J; Oksala, NKJ; Laaksonen, DE; Khanna, S; Kokkola, T; Kaarniranta, K; Sen, CK; Atalay, M (Wiley-Blackwell, 2018)
      Impaired expression of heat shock proteins (HSPs) and increased oxidative stress may contribute to the pathophysiology of diabetes by disrupted tissue protection. Acute exercise induces oxidative stress, whereas exercise ...
    • Tear film proteome in age-related macular degeneration 

      Winiarczyk, M; Kaarniranta, K; Winiarczyk, S; Adaszek, ¿; Winiarczyk, D; Mackiewicz, J (Springer Nature, 2018)
      Purpose Age-related macular degeneration (AMD) is the main reason for blindness in elderly people in the developed countries. Current screening protocols have limitations in detecting the early signs of retinal degeneration. ...
    • The role of myeloid-derived suppressor cells (MDSC) in the inflammaging process 

      Salminen, A; Kaarniranta, K; Kauppinen, A (Elsevier BVAlankomaat, 2018)
      A chronic low-grade inflammation is one of the hallmarks of the aging process. This gradually augmenting inflammatory state has been termed inflammaging. Inflammaging is associated with increased myelopoiesis in the bone ...