Browsing by Author "Kaarniranta, Kai"
Now showing items 1-19 of 19
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Autophagy Stimulus Promotes Early HuR Protein Activation and p62/SQSTM1 Protein Synthesis in ARPE-19 Cells by Triggering Erk1/2, p38MAPK, and JNK Kinase Pathways
Marchesi, Nicoletta; Thongon, Natthakan; Pascale, Alessia; Provenzani, Alessandro; Koskela, Ali; Korhonen, Eveliina; Smedowski, Adrian; Govoni, Stefano; Kauppinen, Anu; Kaarniranta, Kai; Amadio, Marialaura (Hindawi Limited, 2018)RNA-binding protein dysregulation and altered expression of proteins involved in the autophagy/proteasome pathway play a role in many neurodegenerative disease onset/progression, including age-related macular degeneration ...Tieteelliset aikakauslehtiartikkelit
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Benefits of switching from latanoprost to preservative-free tafluprost eye drops: a meta-analysis of two Phase IIIb clinical trials
Uusitalo, Hannu; Egorov, Evjeniy; Kaarniranta, Kai; Astakhov, Yuri; Ropo, Auli (Dove Medical Press Ltd., 2016)Introduction: Glaucoma patients frequently exhibit ocular surface side effects during treatment with prostaglandin eye drops. The present work investigated whether glaucoma patients suffering from signs and symptoms of ...info:eu-repo/semantics/article
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Effects of Resvega on Inflammasome Activation in Conjunction with Dysfunctional Intracellular Clearance in Retinal Pigment Epithelial (RPE) Cells
Bhattarai, Niina; Piippo, Niina; Ranta-aho, Sofia; Mysore, Yashavanthi; Kaarniranta, Kai; Kauppinen, Anu (MDPI AG, 2021)Age-related macular degeneration (AMD) is an eye disease in which retinal pigment epithelium (RPE) cells play a crucial role in maintaining retinal homeostasis and photoreceptors’ functionality. During disease progression, ...Tieteelliset aikakauslehtiartikkelit
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ER stress activates immunosuppressive network: implications for aging and Alzheimer's disease
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu (Springer Science and Business Media LLC, 2020)The endoplasmic reticulum (ER) contains stress sensors which recognize the accumulation of unfolded proteins within the lumen of ER, and subsequently these transducers stimulate the unfolded protein response (UPR). The ER ...Tieteelliset aikakauslehtiartikkelit
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Exosomal vesicles enhance immunosuppression in chronic inflammation: Impact in cellular senescence and the aging process
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu (Elsevier BV, 2020)Exosomes represent an evolutionarily conserved signaling pathway which can act as an alarming mechanism in responses to diverse stresses, e.g. chronic inflammation activates the budding of exosomal vesicles in both immune ...Tieteelliset aikakauslehtiartikkelit
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Fatty acids and oxidized lipoproteins contribute to autophagy and innate immunity responses upon the degeneration of retinal pigment epithelium and development of age-related macular degeneration
Kaarniranta, Kai; Koskela, Ali; Felszeghy, Szabolcs; Kivinen, Niko; Salminen, Antero; Kauppinen, Aanu (Elsevier BV, 2019)Retinal pigment epithelium (RPE) damage is a primary sign in the development of age-related macular degeneration (AMD) the leading cause of blindness in western countries. RPE cells are exposed to chronic oxidative stress ...Tieteelliset aikakauslehtiartikkelit
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Inflammation and its role in age-related macular degeneration
Kauppinen, Anu; Paterno, Jussi J; Blasiak, Janusz; Salminen, Antero; Kaarniranta, Kai (Birkhaeuser Verlag AG, 2016)Inflammation is a cellular response to factors that challenge the homeostasis of cells and tissues. Cell-associated and soluble pattern-recognition receptors, e.g. Toll-like receptors, inflammasome receptors, and complement ...info:eu-repo/semantics/article
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MicroRNAs in the regulation of autophagy and their possible use in age-related macular degeneration therapy
Hyttinen, Juha M T; Blasiak, Janusz; Felszeghy, Szabolcs; Kaarniranta, Kai (Elsevier BV, 2021)Age-related macular degeneration (AMD) is a progressive sight-impairing disease of the elderly. The pathogenic mechanisms of AMD are not well understood although both genetic and many environmental factors have been ...Tieteelliset aikakauslehtiartikkelit
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Mitochondrial quality control in AMD: does mitophagy play a pivotal role?
Hyttinen, Juha MT; Viiri, Johanna; Kaarniranta, Kai; Blasiak, Janusz (Springer Nature, 2018)Age-related macular degeneration (AMD) is the predominant cause of visual loss in old people in the developed world, whose incidence is increasing. This disease is caused by the decrease in macular function, due to the ...Tieteelliset aikakauslehtiartikkelit
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Nutraceutical with Resveratrol and Omega-3 Fatty Acids Induces Autophagy in ARPE-19 Cells
Koskela, Ali; Reinisalo, Mika; Petrovski, Goran; Sinha, Debasish; Olmiere, Céline; Karjalainen, Reijo; Kaarniranta, Kai (MDPI AG, 2016)Impaired autophagic and proteasomal cleansing have been documented in aged retinal pigment epithelial (RPE) cells and age-related macular degeneration (AMD). Omega-3 fatty acids and resveratrol have many positive homeostatic ...info:eu-repo/semantics/article
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Oxidative Stress is the Principal Contributor to Inflammasome Activation in Retinal Pigment Epithelium Cells with Defunct Proteasomes and Autophagy
Piippo, Niina; Korhonen, Eveliina; Hytti, Maria; Kinnunen, Kati; Kaarniranta, Kai; Kauppinen, Anu (S. Karger AG, 2018)Background/Aims: Previously, we demonstrated that blockade of the intracellular clearance systems in human retinal pigment epithelial (RPE) cells by MG-132 and bafilomycin A1 (BafA) induces NLRP3 inflammasome signaling. ...Tieteelliset aikakauslehtiartikkelit
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PGC-1alfa Protects RPE Cells of the Aging Retina against Oxidative Stress-Induced Degeneration through the Regulation of Senescence and Mitochondrial Quality Control. The Significance for AMD Pathogenesis
Kaarniranta, Kai; Kajdanek, Jakub; Morawiec, Jan; Pawlowska, Elzbieta; Blasiak, Janusz (MDPI AG, 2018)PGC-1α (peroxisome proliferator-activated receptor gamma coactivator 1-alpha) is a transcriptional coactivator of many genes involved in energy management and mitochondrial biogenesis. PGC-1α expression is associated with ...Tieteelliset aikakauslehtiartikkelit
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Potential Role of Myeloid-Derived Suppressor Cells (MDSCs) in Age-Related Macular Degeneration (AMD)
Kauppinen, Anu; Kaarniranta, Kai; Salminen, Antero (Frontiers Media SA, 2020)Myeloid cells, such as granulocytes/neutrophils and macrophages, have responsibilities that include pathogen destruction, waste material degradation, or antigen presentation upon inflammation. During persistent stress, ...Tieteelliset aikakauslehtiartikkelit
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Regulatory differences of the hsp70 gene response in mammalian cells (Nisäkässolujen stressigeenin (hsp70) säätelypoikkeavuudet)
Kaarniranta, Kai (Kuopion yliopisto; University of Kuopio, 2002)info:eu-repo/semantics/doctoralThesis
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Resvega Alleviates Hydroquinone-Induced Oxidative Stress in ARPE-19 Cells
Bhattarai, Niina; Korhonen, Eveliina; Toppila, Maija; Koskela, Ali; Kaarniranta, Kai; Mysore, Yashavanthi; Kauppinen, Anu (MDPI AG, 2020)Retinal pigment epithelial (RPE) cells maintain homeostasis at the retina and they are under continuous oxidative stress. Cigarette smoke is a prominent environmental risk factor for age-related macular degeneration (AMD), ...Tieteelliset aikakauslehtiartikkelit
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Serum Levels of Plasmalogens and Fatty Acid Metabolites Associate with Retinal Microangiopathy in Participants from the Finnish Diabetes Prevention Study
de Mello, Vanessa Derenji; Selander, Tuomas; Lindström, Jaana; Tuomilehto, Jaakko; Uusitupa, Matti; Kaarniranta, Kai (MDPI AG, 2021)Diabetic retinopathy (DR) is the most common microvascular complication of diabetes, and retinal microaneurysms (MA) are one of the first detected abnormalities associated with DR. We recently showed elevated serum ...Tieteelliset aikakauslehtiartikkelit
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TAS-116, a Well-Tolerated Hsp90 Inhibitor, Prevents the Activation of the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells
Ranta-aho, Sofia; Piippo, Niina; Korhonen, Eveliina; Kaarniranta, Kai; Hytti, Maria; Kauppinen, Anu (MDPI AG, 2021)Chronic inflammation has been associated with several chronic diseases, such as age-related macular degeneration (AMD). The NLRP3 inflammasome is a central proinflammatory signaling complex that triggers caspase-1 activation ...Tieteelliset aikakauslehtiartikkelit
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UV-B-Induced Inflammasome Activation Can Be Prevented by Cis-Urocanic Acid in Human Corneal Epithelial Cells
Korhonen, Eveliina; Bisevac, Jovana; Hyttinen, Juha MT; Piippo, Niina; Hytti, Maria; Kaarniranta, Kai; Petrovski, Goran; Kauppinen, Anu (Association for Research in Vision and Ophthalmology (ARVO), 2020)Purpose: The cornea is continually exposed to highly energetic solar UV-B (280-320 nm). Our aim was to investigate whether UV-B triggers the activation of NLRP3 inflammasomes and the production of IL-1β and/or IL-18 in ...Tieteelliset aikakauslehtiartikkelit
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Wound healing of human embryonic stem cell-derived retinal pigment epithelial cells is affected by maturation stage
Khamidakh,Amna E Abu; Rodriguez-Martinez, Alejandra; Kaarniranta, Kai; Kallioniemi, Anne; Skottman, Heli; Hyttinen, Jari; Juuti-Uusitalo, Kati (Springer Nature America, Inc, 2018)Background Wound healing of retinal pigment epithelium (RPE) is a complex process that may take place in common age-related macular degeneration eye disease. The purpose of this study was to evaluate whether wounding and ...Tieteelliset aikakauslehtiartikkelit