Now showing items 1-10 of 10

    • Acute detachment of hexokinase II from mitochondria modestly increases oxygen consumption of the intact mouse heart 

      Nederlof R; Denis S; Lauzier B; Rosiers CD; Laakso M; Hagen J; Argmann C; Wanders R; Houtkooper RH; Hollmann MW; Houten SM; Zuurbier CJ (Elsevier BV, 2017)
      Objective Cardiac hexokinase II (HKII) can translocate between cytosol and mitochondria and change its cellular expression with pathologies such as ischemia–reperfusion, diabetes and heart failure. The cardiac metabolic ...

    • Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study 

      Davis JP; Huyghe JR; Locke AE; Jackson AU; Sim X; Stringham HM; Teslovich TM; Welch RP; Fuchsberger C; Narisu N; Chines PS; Kangas AJ; Soininen P; Ala-Korpela M; Kuusisto J; Collins FS; Laakso M; Boehnke M; Mohlke KL (Public Library of Science (PLoS), 2017)
      Lipid and lipoprotein subclasses are associated with metabolic and cardiovascular diseases, yet the genetic contributions to variability in subclass traits are not fully understood. We conducted single-variant and gene-based ...

    • Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes 

      Mardinoglu A; Gogg S; Lotta LA; Stancáková A; Nerstedt A; Boren J; Blüher M; Ferrannini E; Langenberg C; Wareham NJ; Laakso M; Smith U (Elsevier BV, 2018)
      Branched-chain amino acids (BCAAs) metabolite, 3-Hydroxyisobutyric acid (3-HIB) has been identified as a secreted mediator of endothelial cell fatty acid transport and insulin resistance (IR) using animal models. To identify ...

    • A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors 

      Brænne I; Willenborg C; Tragante V; Kessler T; Zeng L; Reiz B; Kleinecke M; von Ameln S; Willer CJ; Laakso M; Wild PS; Zeller T; Wallentin L; Franks PW; Salomaa V; Dehghan A; Meitinger T; Samani NJ; Asselbergs FW; Erdmann J; Schunkert H (Springer Nature, 2017)
      Cyclooxygenase-2 inhibitors (coxibs) are characterized by multiple molecular off-target effects and increased coronary artery disease (CAD) risk. Here, we systematically explored common variants of genes representing ...

    • Heterozygous RFX6 protein truncating variants are associated with MODY with reduced penetrance 

      Patel KA; Kettunen J; Laakso M; Stancáková A; Laver TW; Colclough K; Johnson MB; Abramowicz M; Groop L; Miettinen PJ; Shepherd MH; Flanagan SE; Ellard S; Inagaki N1; Hattersley AT; Tuomi T; Cnop M; Weedon MN (Springer Nature, 2017)
      Finding new causes of monogenic diabetes helps understand glycaemic regulation in humans. To find novel genetic causes of maturity-onset diabetes of the young (MODY), we sequenced MODY cases with unknown aetiology and ...

    • The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer's pathology 

      Westwood S; Liu B; Baird AL; Anand S; Nevado-Holgado AJ; Newby D; Pikkarainen M; Hallikainen M; Kuusisto J; Streffer JR; Novak G; Blennow K; Andreasson U; Zetterberg H; Smith U; Laakso M; Soininen H; Lovestone S (Springer Nature, 2017)
      Background Insulin resistance (IR) has previously been associated with an increased risk of developing Alzheimer’s disease (AD), although the relationship between IR and AD is not yet clear. Here, we examined the influence ...

    • Plant-derived compounds strigolactone GR24 and pinosylvin activate SIRT1 and enhance glucose uptake in rat skeletal muscle cells 

      Modi S; Yaluri N; Kokkola T; Laakso M (Springer Nature, 2017)
      Insulin resistance is a characteristic finding in hyperglycaemia and type 2 diabetes. SIRT1 is a NAD+ dependent deacetylase that plays a central role in glucose homeostasis and energy metabolism. SIRT1 activators, including ...

    • Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort 

      Org E; Blum Y; Kasela S; Mehrabian M; Kuusisto J; Kangas AJ; Soininen P; Wang ZN; Ala-Korpela M; Hazen SL; Laakso M; Lusis AJ (Springer Nature, 2017)
      Background The gut microbiome is a complex and metabolically active community that directly influences host phenotypes. In this study, we profile gut microbiota using 16S rRNA gene sequencing in 531 well-phenotyped Finnish ...

    • Role of osteopontin and its regulation in pancreatic islet 

      Cai M; Bompada P; Salehi A; Acosta JR; Prasad RB; Atac D; Laakso M; Groop L; De Marinis Y (Elsevier BV, 2018)
      Osteopontin (OPN) is involved in various physiological processes and also implicated in multiple pathological states. It has been suggested that OPN may have a role in type 2 diabetes (T2D) by protecting pancreatic islets ...
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    • Trans-ancestry Fine Mapping and Molecular Assays Identify Regulatory Variants at the ANGPTL8 HDL-C GWAS Locus 

      Cannon ME; Duan Q; Wu Y; Zeynalzadeh M; Xu Z; Kangas AJ; Soininen P; Ala-Korpela M; Civelek M; Lusis AJ; Kuusisto J; Collins FS; Boehnke M; Tang H; Laakso M; Li Y; Mohlke K (Genetics Society of America, 2017)
      Recent genome-wide association studies (GWAS) have identified variants associated with high-density lipoprotein cholesterol (HDL-C) located in or near the ANGPTL8 gene. Given the extensive sharing of GWAS loci across ...