Now showing items 1-2 of 2

    • Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice 

      Gabbouj, S; Natunen, T; Koivisto, H; Jokivarsi, K; Takalo, M; Marttinen, M; Wittrahm, R; Kemppainen, S; Naderi, R; Posado-Fernández, A; Ryhänen, S; Mäkinen, P; Paldanius, KMA; Doria, G; Poutiainen, P; Flores, O; Haapasalo, A; Tanila, H; Hiltunen, M (Elsevier BVYhdysvallat (USA), 2019)
      Type 2 diabetes mellitus (T2DM) increases the risk for Alzheimer's disease (AD). Human AD brains show reduced glucose metabolism as measured by [18F]fluoro-2-deoxy-2-D-glucose positron emission tomography (FDG-PET). Here, ...
    • Progressive age-dependent motor impairment in human tau P301S overexpressing mice 

      Koivisto, H; Ytebrouck, E; Carmans, S; Naderi, R; Miettinen, PO; Roucourt, B; Tanila, H (Elsevier BVAlankomaat, 2019)
      This study assessed the development of motor deficits in female hTau.P301S transgenic mice from 1.5 to 5.5 months of age. The test battery included clasping reflex, grid hanging, Rotarod test, spontaneous explorative ...