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    • Caspase-8, association with Alzheimer's Disease and functional analysis of rare variants 

      Rehker J; Rodhe J; Nesbitt RR; Boyle EA; Martin BK; Lord J; Karaca I; Naj A; Jessen F; Helisalmi S; Soininen H; Hiltunen M; Ramirez A; Scherer M; Farrer LA; Haines JL; Pericak-Vance MA; Raskind WH; Cruchaga C; Schellenberg GD; Joseph B; Brkanac Z (Public Library of Science (PLoS), 2017)
      The accumulation of amyloid beta (Aβ) peptide (Amyloid cascade hypothesis), an APP protein cleavage product, is a leading hypothesis in the etiology of Alzheimer's disease (AD). In order to identify additional AD risk ...