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    • Substituted arylsulphonamides as inhibitors of perforin-mediated lysis 

      Spicer JA; Miller CK; O'Connor PD; Jose J; Huttunen KM; Jaiswal JK; Denny WA; Akhlaghi H; Browne KA; Trapani JA (Elsevier BV, 2017)
      The structure-activity relationships for a series of arylsulphonamide-based inhibitors of the pore-forming protein perforin have been explored. Perforin is a key component of the human immune response, however inappropriate ...