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    • Controlling of N-Alkylpolyamine Analogue Metabolism by Selective Deuteration 

      Ucal, S; Häkkinen, MR; Alanne, AL; Alhonen, L; Vepsäläinen, J; Keinänen, TA; Hyvönen, MT (Portland Press Ltd., 2018)
      Replacing protium with deuterium is an efficient method to modulate drug metabolism. N-alkylated polyamine analogues are polyamine antimetabolites with proven anticancer efficacy. We have characterized earlier the preferred ...