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    • Comprehensive evaluation of coding region point mutations in microsatellite-unstable colorectal cancer 

      Kondelin, J; Salokas, K; Saarinen, L; Ovaska, K; Rauanheimo, H; Plaketti, RM; Hamberg, J; Liu, X; Yadav, L; Gylfe, AE; Cajuso, T; Hänninen, UA; Palin, K; Ristolainen, H; Katainen, R; Kaasinen, E; Tanskanen, T; Aavikko, M; Taipale, M; Taipale, J; Renkonen-Sinisalo, L; Lepistö, A; Koskensalo, S; Böhm, J; Mecklin, JP; Ongen, H; Dermitzakis, ET; Kilpivaara, O; Vahteristo, P; Turunen, M; Hautaniemi, S; Tuupanen, S; Karhu, A; Välimäki, N; Varjosalo, M; Pitkänen, E; Aaltonen, LA (EMBO, 2018)
      Microsatellite instability (MSI) leads to accumulation of an excessive number of mutations in the genome, mostly small insertions and deletions. MSI colorectal cancers (CRCs), however, also contain more point mutations ...