Browsing by Departments "A.I. Virtanen -instituutti,School of Medicine / Clinical Medicine"

Now showing items 1-5 of 5

    • A multiomic approach to characterize the temporal sequence in Alzheimer's disease-related pathology 

      Marttinen, M; Paananen, J; Neme, A; Mitra, V; Takalo, M; Natunen, T; Paldanius, KMA; Mäkinen, P; Bremang, M; Kurki, MI; Rauramaa, T; Leinonen, V; Soininen, H; Haapasalo, A; Pike, I; Hiltunen, M (Elsevier BV, 2019)
      No single-omic approach completely elucidates the multitude of alterations taking place in Alzheimer's disease (AD). Here, we coupled transcriptomic and phosphoproteomic approaches to determine the temporal sequence of ...
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    • Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer's Disease 

      Marttinen, Mikael; Takalo, Mari; Natunen, Teemu; Wittrahm, Rebekka; Gabbouj, Sami; Kemppainen, Susanna; Leinonen, Ville; Tanila, Heikki; Haapasalo, Annakaisa; Hiltunen, Mikko (Frontiers Media SA, 2018)
      Alzheimer’s disease (AD) is the most common neurodegenerative disorder, which is clinically associated with a global cognitive decline and progressive loss of memory and reasoning. According to the prevailing amyloid cascade ...
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    • Prevalence of immunological diseases in a Finnish frontotemporal lobar degeneration cohort with the C9orf72 repeat expansion carriers and non-carriers 

      Katisko, K; Solje, E; Koivisto, AM; Krüger, J; Kinnunen, T; Hartikainen, P; Helisalmi, S; Korhonen, V; Herukka, S-K; Haapasalo, A; Remes, AM (Elsevier BV, 2018)
      Recent studies have suggested a role for immune dysregulation behind the etiology of frontotemporal lobar degeneration (FTLD). Here, we have investigated the prevalence of immunological diseases in FTLD (N = 196) with and ...
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    • S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5 

      Ferreira, Catarina B.; Marttinen, Mikael; Coelho, Joana E.; Paldanius, Kaisa M.A.; Takalo, Mari; Mäkinen, Petra; Leppänen, Luukas; Miranda-Lourenço, Catarina; Fonseca-Gomes, João; Tanqueiro, Sara R.; Vaz, Sandra H.; Belo, Rita F.; Sebastião, Ana Maria; Leinonen, Ville; Soininen, Hilkka; Pike, Ian; Haapasalo, Annakaisa; Lopes, Luísa V.; de Mendonça, Alexandre; Diógenes, Maria José; Hiltunen, Mikko (Elsevier BV, 2022)
      Alzheimer's disease (AD) is the most common form of dementia, which is neuropathologically characterized by extracellular senile plaques containing amyloid-β and intracellular neurofibrillary tangles composed of ...
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    • Suppressed heat shock protein response in the kidney of exercise-trained diabetic rats 

      Lappalainen, J; Oksala, NKJ; Laaksonen, DE; Khanna, S; Kokkola, T; Kaarniranta, K; Sen, CK; Atalay, M (Wiley-Blackwell, 2018)
      Impaired expression of heat shock proteins (HSPs) and increased oxidative stress may contribute to the pathophysiology of diabetes by disrupted tissue protection. Acute exercise induces oxidative stress, whereas exercise ...
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