Browsing by Series "Journal of controlled release"
Now showing items 1-3 of 3
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Mechanisms of cellular retention of melanin bound drugs: Experiments and computational modeling
(Elsevier B.V, 2022)Melanin binding of drugs is known to increase drug concentrations and retention in pigmented eye tissues. Even though the correlation between melanin binding in vitro and exposure to pigmented eye in vivo has been shown, ...
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Release of functional dexamethasone by intracellular enzymes: A modular peptide-based strategy for ocular drug delivery
(Elsevier BV, 2020)Tissue barriers limit drug delivery in the eye. Therefore, retinal diseases are treated with intravitreal injections. Delivery systems with reduced dosing frequency and/or cellular drug delivery properties are needed. We ...Tieteelliset aikakauslehtiartikkelit
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Retinal neuroprotection by controlled release of a VCP inhibitor from self-assembled nanoparticles
(Elsevier BV, 2021)Mutations in rhodopsin lead to its misfolding resulting in autosomal dominant retinitis pigmentosa (adRP). Pharmacological inhibition of the ATP-driven chaperone valosin-containing protein (VCP), a molecular checkpoint for ...Tieteelliset aikakauslehtiartikkelit