Now showing items 1-2 of 2

    • Activated hyaluronan metabolism in the tumor matrix - Causes and consequences 

      Tammi, Markku I; Oikari, Sanna; Pasonen-Seppänen, Sanna; Rilla, Kirsi; Auvinen, Päivi; Tammi, Raija H (Elsevier BVAlankomaat, 2019)
      Hyaluronan accumulates in the stroma of several solid tumors and promotes their progression. Both enhanced synthesis and fragmentation of hyaluronan are required as a part of this inflammatory process resembling wound ...
    • UDP-sugar accumulation drives hyaluronan synthesis in breast cancer 

      Oikari, S; Kettunen, T; Tiainen, S; Häyrinen, J; Masarwah, A; Sudah, M; Sutela, A; Vanninen, R; Tammi, M; Auvinen, P (Elsevier BV, 2018)
      Increased uptake of glucose, a general hallmark of malignant tumors, leads to an accumulation of intermediate metabolites of glycolysis. We investigated whether the high supply of these intermediates promotes their flow ...