Browsing by Subject "cancer"
Now showing items 1-15 of 15
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Activation of immunosuppressive network in the aging process
(Elsevier BV, 2020)Chronic low-grade inflammation has a key role in the aging process, a state called inflammaging. It is known that the chronic inflammatory condition generates counteracting immunosuppressive state in many diseases. ...Tieteelliset aikakauslehtiartikkelit
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Collaborative Autoethnography of Cancer Patients’ Dynamic Sense of Agency
(SAGE Publications, 2024)Through collaborative autoethnography, we studied shifts in cancer patients’ sense of agency and the meaning of cancer during the diagnostic and treatment phases. This article contributes to the illness management literature ...
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Evaluation of FASN inhibitors by a versatile toolkit reveals differences in pharmacology between human and rodent FASN preparations and in antiproliferative efficacy in vitro vs. in situ in human cancer cells
(Elsevier BV, 2020)De novo synthesis of fatty acids is essential to maintain intensive proliferation of cancer cells. Unlike normal cells that utilize food-derived circulating lipids for their fuel, cancer cells rely on heightened lipogenesis ...Tieteelliset aikakauslehtiartikkelit
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Extracellular vesicles are integral and functional components of the extracellular matrix
(Elsevier BV, 2019)Extracellular vesicles (EV) are small plasma membrane-derived particles released into the extracellular space by virtually all cell types. Recently, EV have received increased interest because of their capability to carry ...Tieteelliset aikakauslehtiartikkelit
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Geriatric impairments were directly and indirectly associated with mortality in older patients with cancer: a structural equation analysis
(Elsevier Inc., 2022)Objectives We assessed the direct and indirect effects between six geriatric domains and 6- and 12-month mortality in older cancer patients. Study Design and Setting We included cancer patients aged ≥70 years from the ...
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Hyaluronan synthase 1 : a mysterious enzyme with unexpected functions
(Frontiers Media SA, 2015)Hyaluronan synthase 1 (HAS1) is one of three isoenzymes responsible for cellular hyaluronan synthesis. Interest in HAS1 has been limited because its role in hyaluronan production seems to be insignificant compared to the ...info:eu-repo/semantics/article
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Integrated drug profiling and CRISPR screening identify essential pathways for CAR T cell cytotoxicity
(American Society of Hematology, 2020)Chimeric antigen receptor (CAR) T-cell therapy has proven effective in relapsed and refractory B-cell malignancies, but resistance and relapses still occur. Better understanding of mechanisms influencing CAR T-cell ...Tieteelliset aikakauslehtiartikkelit
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Investigating the atomic interactions between Ago2 and KRAS using molecular dynamics simulations
(Itä-Suomen yliopisto; University of Eastern Finland, 2024)info:eu-repo/semantics/masterThesis
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Low Prevalence of Cancer in Patients with Frontotemporal Lobar Degeneration
(, 2018)Several studies have reported reduced risk of cancer in patients with Alzheimer’s disease (AD) or Parkinson’s disease. The relationship between cancer and frontotemporal lobar degeneration (FTLD) has not been previously ...Tieteelliset aikakauslehtiartikkelit
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Meeting the Spiritual Care Needs of Emerging Adults with Cancer
(MDPI AG, 2020)Every year 90,000 young people in Europe and the USA are newly diagnosed with cancer. The majority of earlier studies have taken a quantitative perspective, rarely focusing on the importance of religiosity and spirituality. ...Tieteelliset aikakauslehtiartikkelit
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Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes
(Elsevier BV, 2019)Stratification of women according to their risk of breast cancer based on polygenic risk scores (PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, optimized for prediction of estrogen ...Tieteelliset aikakauslehtiartikkelit
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Profiling the regulatory interplay of BET bromodomains and Sirtuins in cancer cell lines
(Elsevier, 2022)Alterations in epigenetic marking, due to changes in expression or activity of epigenetic regulators, may affect cancer development and progression and thus, targeting epigenetic regulators provides potential avenues for ...
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Serum n-6 polyunsaturated fatty acids and risk of death: the Kuopio Ischaemic Heart Disease Risk Factor Study
(Oxford University Press (OUP), 2018)Background The cardioprotective properties of linoleic acid (LA), a major n–6 (ω-6) polyunsaturated fatty acid (PUFA), have been recognized, but less is known about its associations with other causes of death. Relatively ...Tieteelliset aikakauslehtiartikkelit
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Toward tailoring radiation protection strategies at an individual level
(Informa UK Limited, 2018)Purpose: From radiation protection viewpoints, there have been continued discussions on potential individual differences in ionizing radiation responses. In October 2017, the International Commission on Radiological ...Tieteelliset aikakauslehtiartikkelit
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Toxicity and resistance of tyrosine kinase inhibitor drugs – Evaluation of 7- hydroxycoumarin derivatives as substrates of phosphorylation
(Itä-Suomen yliopisto; University of Eastern Finland, 2023)info:eu-repo/semantics/masterThesis
