Browsing by Subject "hyaluronan"
Now showing items 1-9 of 9
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Activated hyaluronan metabolism in the tumor matrix - Causes and consequences
(Elsevier BV, 2019)Hyaluronan accumulates in the stroma of several solid tumors and promotes their progression. Both enhanced synthesis and fragmentation of hyaluronan are required as a part of this inflammatory process resembling wound ...Tieteelliset aikakauslehtiartikkelit
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Effects of mutations in the post-translational modification sites on the trafficking of hyaluronan synthase 2 (HAS2)
(Elsevier BV, 2019)Vesicular trafficking of hyaluronan synthases (HAS1-3) from endoplasmic reticulum (ER) through Golgi to plasma membrane (PM), and either back to endosomes and lysosomes, or out into extracellular vesicles, is important for ...Tieteelliset aikakauslehtiartikkelit
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Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas
(Springer Nature, 2018)Background Diffusely infiltrating astrocytomas originate from astrocytic glial cells or their precursor cells and are the most common type of brain tumors in adults. In this retrospective study, we investigated the content ...Tieteelliset aikakauslehtiartikkelit
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Extracellular ATP activates hyaluronan synthase 2 ( HAS2 ) in epidermal keratinocytes via P2Y2, Ca2+-signaling, and MAPK pathways
(Portland Press Ltd., 2018)Extracellular nucleotides are used as signaling molecules by several cell types. In epidermis, their release is triggered by insults such as ultraviolet radiation, barrier disruption, and tissue wounding, and by specific ...Tieteelliset aikakauslehtiartikkelit
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Hyaluronan histochemistry - A potential new tool to assess the progress of liver disease from simple steatosis to hepatocellular carcinoma
(Oxford University Press (OUP), 2019)Nonalcoholic fatty liver disease is among the most common liver diseases worldwide and one cause of cirrhosis that can result in the development of hepatocellular carcinoma (HCC). Hyaluronan (HA) is a high-molecular-mass ...Tieteelliset aikakauslehtiartikkelit
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Hyaluronan synthase 1 : a mysterious enzyme with unexpected functions
(Frontiers Media SA, 2015)Hyaluronan synthase 1 (HAS1) is one of three isoenzymes responsible for cellular hyaluronan synthesis. Interest in HAS1 has been limited because its role in hyaluronan production seems to be insignificant compared to the ...info:eu-repo/semantics/article
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The Impact of Hyaluronan on Tumor Progression in Cutaneous Melanoma
(Frontiers Media S.A., 2022)The incidence of cutaneous melanoma is rapidly increasing worldwide. Cutaneous melanoma is an aggressive type of skin cancer, which originates from malignant transformation of pigment producing melanocytes. The main risk ...
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The role of TSG-6 in inflammatory hyaluronan matrix of melanoma cells
(Itä-Suomen yliopisto; University of Eastern Finland, 2023)info:eu-repo/semantics/masterThesis
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UDP-sugar accumulation drives hyaluronan synthesis in breast cancer
(Elsevier BV, 2018)Increased uptake of glucose, a general hallmark of malignant tumors, leads to an accumulation of intermediate metabolites of glycolysis. We investigated whether the high supply of these intermediates promotes their flow ...Tieteelliset aikakauslehtiartikkelit
