Browsing by Subject "neurodegeneration"

Now showing items 1-8 of 8

    • Brief isoflurane anesthesia regulates striatal AKT-GSK3ß signaling and ameliorates motor deficits in a rat model of early-stage Parkinson's disease 

      Leikas J V; Kohtala S; Theilmann W; Jalkanen A J; Forsberg M M; Rantamäki T (Wiley-Blackwell, 2017)
      Parkinson's disease (PD) is a progressive neurodegenerative movement disorder primarily affecting the nigrostriatal dopaminergic system. The link between heightened activity of glycogen synthase kinase 3β (GSK3β) and ...
      info:eu-repo/semantics/article

    • CuII(atsm) Attenuates Neuroinflammation 

      Choo, Xin Yi; Liddell, Jeffrey R; Huuskonen, Mikko T; Grubman, Alexandra; Moujalled, Diane; Roberts, Jessica; Kysenius, Kai; Patten, Lauren; Quek, Hazel; Oikari, Lotta E; Duncan, Clare; James, Simon A; McInnes, Lachlan E; Hayne, David J; Donnelly, Paul S; Pollari, Eveliina; Vähätalo, Suvi; Lejavová, Katarína; Kettunen, Mikko I; Malm, Tarja; et al. [Incl Koistinaho, Jari; Kanninen, Katja] (Frontiers Media SA, 2018)
      Background: Neuroinflammation and biometal dyshomeostasis are key pathological features of several neurodegenerative diseases, including Alzheimer’s disease (AD). Inflammation and biometals are linked at the molecular level ...
      Tieteelliset aikakauslehtiartikkelit

    • Impaired mitochondrial fatty acid synthesis leads to neurodegeneration in mice 

      Nair, Remya R; Koivisto, Henna; Jokivarsi, Kimmo; Miinalainen, Ilkka J; Autio, Kaija J; Manninen, Aki; Poutiainen, Pekka; Tanila, Heikki; Hiltunen, J Kalervo; Kastaniotis, Alexander J (Society for Neuroscience, 2018)
      There has been a growing interest toward mitochondrial fatty acid synthesis (mtFAS) since the recent discovery of a neurodegenerative human disorder termed MEPAN (mitochondrial enoyl reductase protein associated ...
      Tieteelliset aikakauslehtiartikkelit

    • Insulin-Like Growth Factors in the Pathogenesis of Neurological Diseases in Children 

      Riikonen Raili (MDPI AG, 2017)
      Insulin-like growth factors play a key role for neuronal growth, differentiation, the survival of neurons and synaptic formation. The action of IGF-1 is most pronounced in the developing brain. In this paper we will try ...
      info:eu-repo/semantics/article

    • Mitochondrial Function in Alzheimer's Disease: Focus on Astrocytes 

      Lampinen, Riikka; Belaya, Irina; Boccuni, Isabella; Malm, Tarja; Kanninen, Katja M (InTech, 2018)
      The brain is one of the most energy-requiring organs in the human body. Mitochondria not only generate this energy, but are centrally involved critical cellular functions including maintenance of calcium homeostasis, ...
      Artikkelit tieteellisissä kokoomateoksissa

    • NDUFA1 p.Gly32Arg variant in early-onset dementia 

      Huttula, Samuli; Väyrynen, Henri; Helisalmi, Seppo; Kytövuori, Laura; Luukkainen, Laura; Hiltunen, Mikko; Remes, Anne M; Krüger, Johanna (Elsevier Inc., 2022)
      Early-onset dementia (EOD) is highly heritable. However, in many EOD cases the genetic etiology remains unknown. Mitochondrial dysfunction is associated with neurodegeneration and the complex I (CI) deficiency is the most ...

    • New Implications for the Role for Ubiquilin-1 in Molecular Mechanisms of Alzheimer's Disease: Interrelationship with BACE1 

      Takalo Mari; Natunen Teemu; Leskelä Stina; Paldanius Kaisa MA; Soininen Hilkka; Hiltunen MIkko; Haapasalo Annakaisa (2017)
      Ample evidence links ubiquilins to the pathogenesis of various neurodegenerative disorders. Ubiquilin-1 (also called PLIC-1) is associated to the pathogenesis of Alzheimer’s disease (AD) both genetically and functionally ...
      Tieteelliset aikakauslehtiartikkelit

    • Subacute inhalation of ultrafine particulate matter triggers inflammation without altering amyloid beta load in 5xFAD mice 

      Saveleva, Liudmila; Vartiainen, Petra; Górová, Veronika; Chew, Sweelin; Belaya, Irina; Konttinen, Henna; Zucchelli, Martina; Korhonen, Paula; Kaartinen, Emma; Kortelainen, Miika; Lamberg, Heikki; Sippula, Olli; Malm, Tarja; Jalava, Pasi I; Kanninen, Katja M (Elsevier B.V., 2022)
      Epidemiological studies reveal that air pollution exposure may exacerbate neurodegeneration. Ultrafine particles (UFPs) are pollutants that remain unregulated in ambient air by environmental agencies. Due to their small ...