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dc.contributor.authorTurunen, Mikael J.
dc.contributor.authorToyras, Juha
dc.contributor.authorKokkonen, Harri T
dc.contributor.authorJurvelin, Jukka S.
dc.date.accessioned2016-06-27T08:04:22Z
dc.date.available2016-06-27T08:04:22Z
dc.date.issued2015-04-28
dc.identifier10.1109/TMI.2015.2426684
dc.identifier.issn0278-0062
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/102
dc.descriptionArticle
dc.description.abstractContrast agent enhanced cone beam computed tomography (CE-CBCT), a technique capable of high-resolution in vivo imaging with small radiation dose, has been applied successfully for clinical diagnostics of cartilage degeneration, i.e., osteoarthritis (OA). As an X-ray technique, CE-CBCT may also detect changes in mineral density of subchondral bone (volumetric bone mineral density, vBMD), known to be characteristic for OA. However, its feasibility for density measurements is not clear due to limited signal-to-noise ratio and contrast of CBCT images. In the present study, we created clinically applicable hydroxyapatite phantoms and determined vBMDs of cortical bone, trabecular bone, subchondral trabecular bone and subchondral plate of 10 cadaver (ex vivo) and 10 volunteer (in vivo) distal femora using a clinical CBCT scanner, and for reference, also using a conventional CT scanner. Our results indicated strong linear correlations between the vBMD values measured with the CT and CBCT scanners , however, absolute vBMD values were dependent on the scanner in use. Further, the differences between the vBMDs of cortical bone, trabecular bone and subchondral bone were similar and independent of the scanner. The present results indicate that vBMD values might not be directly comparable between different instruments. However, based on our present and previous results, we propose that, for OA diagnostics, clinical CBCT enables not only quantitative analysis of articular cartilage but also subchondral bone vBMD. Quantitative information on both cartilage and subchondral bone could be beneficial in OA diagnostics.fi_FI
dc.language.isoenfi_FI
dc.publisherInstitute of Electrical & Electronics Engineers (IEEE)fi_FI
dc.relation.ispartofseriesIEEE Transactions on Medical Imaging 34 (10);
dc.relation.urihttp://dx.doi.org/10.1109/TMI.2015.2426684
dc.rightsAll rights reserved
dc.subjectbonefi_FI
dc.subjectcomputerised tomographyfi_FI
dc.subjectdensity measurementfi_FI
dc.subjectdiseasesfi_FI
dc.titleQuantitative Evaluation of Knee Subchondral Bone Mineral Density Using Cone Beam Computed Tomographyfi_FI
dc.typehttp://purl.org/eprint/type/JournalArticle
dc.description.versionFinal Draft
dc.contributor.departmentFaculty of Science and Forestry
uef.solecris.id37338016
eprint.statushttp://purl.org/eprint/status/PeerReviewed
dc.type.publicationinfo:eu-repo/semantics/article
dc.rights.accessrights© IEEE
dc.relation.doi10.1109/TMI.2015.2426684
dc.description.reviewstatushttp://purl.org/eprint/status/PeerReviewed
dc.relation.issn0278-0062
dc.rights.accesslevelopenAccess


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