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dc.contributor.authorLeppänen, Maija
dc.contributor.authorKorpi, Anne
dc.contributor.authorYli-Pirilä, Pasi
dc.contributor.authorLehto, Maili
dc.contributor.authorWolff, Henrik
dc.contributor.authorKosma, Veli-Matti
dc.contributor.authorAlenius, Harri
dc.contributor.authorPasanen, Pertti
dc.date.accessioned2016-07-01T07:06:46Z
dc.date.available2016-07-01T07:06:46Z
dc.date.issued2015-07-15
dc.identifier10.3109/08958378.2015.1056890
dc.identifier.citationNegligible respiratory irritation and inflammation potency of pigmentary TiO2 in mice Maija Leppänen , Anne Korpi , Pasi Yli-Pirilä , Maili Lehto , Henrik Wolff , Veli-Matti Kosma , Harri Alenius , Pertti Pasanen Inhalation Toxicology Vol. 27, Iss. 8, 2015fi_FI
dc.identifier.issn0895-8378
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/109
dc.descriptionArticle
dc.description.abstractTitanium dioxide (TiO2) is manufactured in millions of tons yearly, and it is used widely as pigment in various applications. Until recently, TiO2 was considered toxicologically harmless and without adverse health effects. In this study, respiratory irritation and inflammation potencies of commercially available pigmentary TiO2 particles (<5 µm, rutile) were studied. Single head-only exposures (30 min) of male Crl:OF1 mice at mass concentrations 6, 11, 21, and 37 mg/m3, and repeated exposures (altogether 16 h, 1 h/day, 4 days/week for 4 weeks) of female BALB/c/Sca mice at mass concentration of 16 mg/m3 to pigmentary TiO2 were conducted. Minor sensory irritation was observed during acute and repeated exposures seen as elongation of the break after the inhalation, which is typical in sensory irritation, and caused by closure of the glottis inhibiting airflow from the lungs after inspiration. No pulmonary irritation, airflow limitation, nasal or pulmonary inflammation was observed. In conclusion, the respiratory irritation and inflammation potencies of the studied pigmentary TiO2 particles seemed to be low and thus can serve as an ideal control exposure agent in short-term studies in mice.fi_FI
dc.language.isoenfi_FI
dc.publisherInforma Healthcarefi_FI
dc.relation.ispartofseriesInhalation Toxicology
dc.relation.urihttp://dx.doi.org/10.3109/08958378.2015.1056890
dc.rightsAll rights reserved
dc.subjectAirway irritationfi_FI
dc.subjectinflammationfi_FI
dc.subjectinhalationfi_FI
dc.subjecttitanium dioxidefi_FI
dc.titleNegligible respiratory irritation and inflammation potency of pigmentary TiO 2 in micefi_FI
dc.typehttp://purl.org/eprint/type/JournalArticle
dc.description.versionFinal Draft
dc.contributor.departmentFaculty of Science and Forestry
uef.solecris.id34549443
eprint.statushttp://purl.org/eprint/status/PeerReviewed
dc.type.publicationinfo:eu-repo/semantics/article
dc.rights.accessrights© Informa UK Limited
dc.relation.doi10.3109/08958378.2015.1056890
dc.description.reviewstatushttp://purl.org/eprint/status/PeerReviewed
dc.format.pagerange378-386
dc.relation.issn0895-8378
dc.relation.issue8
dc.relation.volume27
dc.rights.accesslevelopenAccess


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