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dc.contributor.authorTiihonen, Miia
dc.contributor.authorTaipale, Heidi
dc.contributor.authorTanskanen, Antti
dc.contributor.authorTiihonen, Jari
dc.contributor.authorHartikainen, Sirpa
dc.date.accessioned2016-09-23T06:54:57Z
dc.date.available2016-09-23T06:54:57Z
dc.date.issued2016
dc.identifier10.3233/JAD-151181fi_FI
dc.identifier.citationTiihonen, M., Taipale, H., Tanskanen, A., Tiihonen, J., Hartikainen, S. 2016. Incidence and Duration of Cumulative Bisphosphonate Use among Community-Dwelling Persons with or without Alzheimer’s Disease. Journal of Alzheimer's Disease 52, 127-132.
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/129
dc.descriptionArticle
dc.description.abstractWe studied the incidence and duration of cumulative bisphosphonate use among older Finnish women and men with or without Alzheimer’s disease (AD). The MEDALZ-2005 cohort is a nationwide sample of all persons with clinically diagnosed AD on 31 December 2005 and their age-, gender-, and region of residence-matched control persons without AD. Information on bisphosphonate use by persons with an AD diagnosis and their controls without AD during 2002–2009 was obtained from the prescription register database containing reimbursed medications. A total of 6,041 (11.8%) persons used bisphosphonates during the 8-year follow-up. Bisphosphonates were more commonly used among persons without AD (n = 3121, 12.3%) than among persons with AD (n = 2,920, 11.2%) (p = 0.001). The median duration of bisphosphonate use was 743 days (IQR). Among persons with AD, the median duration of use was 777 days (IQR) and among persons without AD, 701 days (IQR) (p = 0.011). People without AD more often used bisphosphonate combination preparations including vitamin D than did people with AD (p <  0.0001). Bisphosphonate use was more common among people without AD who had comorbidities, asthma/COPD, or rheumatoid arthritis compared with users with AD. Short-term users were more likely to be male, at least 80 years old, and not having AD. Although the incidence of bisphosphonate use was slightly higher among persons without AD, the cumulative duration of bisphosphonate use was longer in persons with AD. Short-term use was associated with male gender, older age, and not having AD.
dc.language.isoenfi_FI
dc.publisherIOS Press
dc.relation.ispartofseriesJournal of Alzheimer's Disease
dc.relation.urihttp://doi.org/10.3233/JAD-151181
dc.rightsCC BY 4.0 https://creativecommons.org/licenses/by-nc/4.0/
dc.titleIncidence and Duration of Cumulative Bisphosphonate Use among Community-Dwelling Persons with or without Alzheimer's Diseasefi_FI
dc.typehttp://purl.org/eprint/type/JournalArticle
dc.rights.license
dc.description.versionPublisher's pdf
dc.contributor.departmentFaculty of Health Sciences
dc.contributor.departmentSchool of Pharmacy, Activities
dc.contributor.departmentSchool of Medicine / Clinical Medicine
uef.solecris.id39812925
eprint.statushttp://purl.org/eprint/status/PeerReviewedfi_FI
dc.type.publicationinfo:eu-repo/semantics/article
dc.rights.accessrights© Authors
dc.relation.doi10.3233/JAD-151181
dc.description.reviewstatushttp://purl.org/eprint/status/PeerReviewed
dc.format.pagerange127-132
dc.relation.issue1
dc.relation.volume52


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