Browsing Artikkelit by Title
Now showing items 1-20 of 2141
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1,2,6-thiadiazinones as novel narrow spectrum calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) Inhibitors
(MDPI AG, 2018)We demonstrate for the first time that 4H-1,2,6-thiadiazin-4-one (TDZ) can function as a chemotype for the design of ATP-competitive kinase inhibitors. Using insights from a co-crystal structure of a 3,5-bis(arylamino)-4 ... -
100 years of atmospheric and marine observations at the Finnish Utö Island in the Baltic Sea
(Copernicus GmbHSaksa, 2018)The Utö Atmospheric and Marine Research Station introduced in this paper is located on Utö Island (59°46.84′N, 21°22.13′E) at the outer edge of the Archipelago Sea, by the Baltic Sea towards the Baltic Proper. Meteorological ... -
24-month intervention with a specific multinutrient in people with prodromal Alzheimer's disease (LipiDiDiet): a randomised, double-blind, controlled trial
(Elsevier BV, 2017)Background Nutrition is an important modifiable risk factor in Alzheimer's disease. Previous trials of the multinutrient Fortasyn Connect showed benefits in mild Alzheimer's disease dementia. LipiDiDiet investigated the ... -
25 years of advances in the definition, classification and treatment of status epilepticus
(Elsevier BV, 2016)Purpose Status epilepticus (SE) requires not only urgent symptomatic treatment with antiepileptic drugs but also rapid identification and treatment of its cause. This narrative review summarizes the most important advances ... -
3D human brain cell models: New frontiers in disease understanding and drug discovery for neurodegenerative diseases
(Elsevier BVAlankomaat, 2018)Neurodegenerative disorders have an enormous impact on society and healthcare budgets. There has been a high degree of failure in many recent clinical trials for disease-modifying therapeutics. A major factor in this failure ... -
3D Morphometric analysis of calcified cartilage properties using micro-computed tomography
(Elsevier BV, 2018)Objective Our aim is to establish methods for quantifying morphometric properties of calcified cartilage (CC) from micro-computed tomography (μCT). Furthermore, we evaluated the feasibility of these methods in investigating ... -
5 years of successful inducible transgene expression following locoregional AAV delivery in nonhuman primates with no detectable immunity
(Mary Ann Liebert Inc, 2019)Anti-transgene immune responses elicited after intramuscular (i.m.) delivery of recombinant adeno-associated virus (rAAV) have been shown to hamper long-term transgene expression in large-animal models of rAAV-mediated ... -
A Brief Survey on Six Basic and Reduced eHealth Indicators in Seven Countries in 2017
(Georg Thieme Verlag KGSaksa, 2018)Background Holistic, ubiquitous support of patient-centered health care (eHealth) at all health care institutions and in patients' homes through information processing is increasingly supplementing institution-centered ... -
A century of trends in adult human height
(eLife Sciences Organisation, Ltd., 2016)Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height ... -
A Combined Field and Laboratory Study on Activated Carbon-Based Thin Layer Capping in a PCB-Contaminated Boreal Lake
(American Chemical Society (ACS), 2018)The in situ remediation of aquatic sediments with activated carbon (AC)-based thin layer capping is a promising alternative to traditional methods, such as sediment dredging. Applying a strong sorbent like AC directly to ... -
A comparative study on household level energy consumption and related emissions from renewable (biomass) and non-renewable energy sources in Bangladesh
(Elsevier BV, 2018)In developing countries, securing clean and equal energy access for all is often constrained by lack of understanding of households’ energy dependency and influencing factors. This study investigates household-level energy ... -
A Comparison of Nonlinear Measures for the Detection of Cardiac Autonomic Neuropathy from Heart Rate Variability
(MDPI AG, 2015-03-19)In this work we compare three multiscale measures for their ability to discriminate between participants having cardiac autonomic neuropathy (CAN) and aged controls. CAN is a disease that involves nerve damage leading to ... -
A comparison of regret-based and utility-based discrete choice modelling - an empirical illustration with hospital bed choice
(Informa UK Limited, 2018)There is some concern that the unobserved preference heterogeneity in random utility maximization theory-based discrete choice experiment modelling is an important source of error variability. The randomness in utility is ... -
A Development of Clinical Decision Support System for Video Head Impulse Test Based on Fuzzy Inference System
(Hindawi Limited, 2018)This paper represents the clinical decision support system for video head impulse test (vHIT) based on fuzzy inference system. It examines the eye and head movement recorded by the eye movement tracking device, calculates ... -
A Fibre-Reinforced Poroviscoelastic Model Accurately Describes the Biomechanical Behaviour of the Rat Achilles Tendon
(Public Library of Science (PLoS), 2015-06-01)Background Computational models of Achilles tendons can help understanding how healthy tendons are affected by repetitive loading and how the different tissue constituents contribute to the tendon’s biomechanical response. ... -
A Liftless Intervention to Prevent Preterm Birth and Low Birthweight Among Pregnant Ghanaian Women: Protocol of a Stepped-Wedge Cluster Randomized Controlled Trial
(JMIR Publications Inc., 2018)Background: Preterm birth (PTB) is a leading cause of infant morbidity and mortality worldwide. Every year, 20 million babies are born with low birthweight (LBW), about 96% of which occur in low-income countries. Despite ... -
A match made in EAHIL+ICAHIS+ICLC 2015 - experiences of a research-minded initiative at the Workshop in Edinburgh
(EAHIL, 2015)A match made in EAHIL+ICAHIS+ICLC 2015” – a combination of handouts, a bulletin board and some post-it-notes, announcements in Facebook and Twitter, and a workshop session – was an initiative at the EAHIL+ICAHIS+ICLC 2015 ... -
A model framework to retrieve thermodynamic and kinetic properties of organic aerosol from composition-resolved thermal desorption measurements
(Copernicus GmbHSaksa, 2018)Chemical ionization mass spectrometer (CIMS) techniques have been developed that allow for quantitative and composition-resolved measurements of organic compounds as they desorb from secondary organic aerosol (SOA) particles, ... -
A multiomic approach to characterize the temporal sequence in Alzheimer's disease-related pathology
(Elsevier BV, 2019)No single-omic approach completely elucidates the multitude of alterations taking place in Alzheimer's disease (AD). Here, we coupled transcriptomic and phosphoproteomic approaches to determine the temporal sequence of ... -
A new crystal form of Aspergillus oryzae catechol oxidase and evaluation of copper site structures in coupled binuclear copper enzymes
(Public Library of Science (PLoS), 2018)Coupled binuclear copper (CBC) enzymes have a conserved type 3 copper site that binds molecular oxygen to oxidize various mono- and diphenolic compounds. In this study, we found a new crystal form of catechol oxidase from ...
