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Enhanced gene expression by a novel designed leucine zipper endosomolytic peptide
(Elsevier BV, 2021)
articleartikkeli
An endosomal trap is a major barrier in gene therapy. We have designed an endosomolytic peptide based on the leucine zipper sequence and characterized it both structurally and functionally. The results illustrated that ...
Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas
(Springer Nature, 2018)
articleartikkeli
Background
Diffusely infiltrating astrocytomas originate from astrocytic glial cells or their precursor cells and are the most common type of brain tumors in adults. In this retrospective study, we investigated the content ...
Activated hyaluronan metabolism in the tumor matrix - Causes and consequences
(Elsevier BV, 2019)
articleartikkeli
Hyaluronan accumulates in the stroma of several solid tumors and promotes their progression. Both enhanced synthesis and fragmentation of hyaluronan are required as a part of this inflammatory process resembling wound ...
Neuron-astrocyte transmitophagy is altered in Alzheimer's disease
(Elsevier Inc., 2022)
ArtikkeliArticle
Under physiological conditions in vivo astrocytes internalize and degrade neuronal mitochondria in a process called transmitophagy. Mitophagy is widely reported to be impaired in neurodegeneration but it is unknown whether ...
Nano-enabled strategies to combat methicillin-resistant Staphylococcus aureus
(Elsevier BV, 2021)
ArtikkeliArticle
The emergence of methicillin-resistant Staphylococcus aureus (MRSA) has become a threat to global health because of limited treatments. MRSA infections are difficult to treat due to increasingly developing resistance in ...
Precipitation-based extracellular vesicle isolation from rat plasma co-precipitate vesicle-free microRNAs
(Informa UK Limited, 2019)
articleartikkeli
The microRNA (miRNA) cargo contained in plasma extracellular vesicles (EVs) offers a relatively little explored source of biomarkers for brain diseases that can be obtained noninvasively. Methods to isolate EVs from plasma, ...
Hyaluronan histochemistry - A potential new tool to assess the progress of liver disease from simple steatosis to hepatocellular carcinoma
(Oxford University Press (OUP), 2019)
articleartikkeli
Nonalcoholic fatty liver disease is among the most common liver diseases worldwide and one cause of cirrhosis that can result in the development of hepatocellular carcinoma (HCC). Hyaluronan (HA) is a high-molecular-mass ...
Cell protrusions induced by hyaluronan synthase 3 (HAS3) resemble mesothelial microvilli and share cytoskeletal features of filopodia
(Elsevier BV, 2015)
articleartikkeli
Previous studies have shown that overexpression of enzymatically active GFP-HAS induces the growth of long, slender protrusions that share many features of both filopodia and microvilli. These protrusions are dependent on ...
Correlative Light and Electron Microscopy Reveals the HAS3-Induced Dorsal Plasma Membrane Ruffles
(Hindawi Publishing Corporation, 2015)
articleartikkeli
Hyaluronan is a linear sugar polymer synthesized by three isoforms of hyaluronan synthases (HAS1, 2, and 3) that forms a hydrated scaffold around cells and is an essential component of the extracellular matrix. The ...
High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation
(Oxford University Press (OUP), 2015)
articleartikkeli
Nucleoli are not only organelles that produce ribosomal subunits. They are also overarching sensors of different stress conditions and they control specific nucleolar stress pathways leading to stabilization of p53. During ...