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dc.contributor.authorAho, Vilma
dc.contributor.authorOllila, Hanna M
dc.contributor.authorKronholm, Erkki
dc.contributor.authorBondia-Pons, Isabel
dc.contributor.authorSoininen, Pasi
dc.contributor.authorKangas, Antti J
dc.contributor.authorHilvo, Mika
dc.contributor.authorSeppälä, Ilkka
dc.contributor.authorKettunen, Johannes
dc.contributor.authorOikonen, Mervi
dc.contributor.authorRaitoharju, Emma
dc.contributor.authorHyötyläinen, Tuulia
dc.contributor.authorKähönen, Mika
dc.contributor.authorViikari, Jorma S
dc.contributor.authorHärmä, Mikko
dc.contributor.authorSallinen, Mikael
dc.contributor.authorOlkkonen, Vesa M
dc.contributor.authorAlenius, Harri
dc.contributor.authorJauhiainen, Matti
dc.contributor.authorPaunio, Tiina et al
dc.date.accessioned2016-10-03T11:01:44Z
dc.date.available2016-10-03T11:01:44Z
dc.date.issued2016
dc.identifierhttp://doi.org/10.1038/srep24828fi_FI
dc.identifier.citationAho, V. et al. Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses. Sci. Rep. 6, 24828; doi: 10.1038/srep24828 (2016).fi_FI
dc.identifier.issn2045-2322
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/134
dc.descriptionArticle
dc.description.abstractSleep loss and insufficient sleep are risk factors for cardiometabolic diseases, but data on how insufficient sleep contributes to these diseases are scarce. These questions were addressed using two approaches: an experimental, partial sleep restriction study (14 cases and 7 control subjects) with objective verification of sleep amount, and two independent epidemiological cohorts (altogether 2739 individuals) with questions of sleep insufficiency. In both approaches, blood transcriptome and serum metabolome were analysed. Sleep loss decreased the expression of genes encoding cholesterol transporters and increased expression in pathways involved in inflammatory responses in both paradigms. Metabolomic analyses revealed lower circulating large HDL in the population cohorts among subjects reporting insufficient sleep, while circulating LDL decreased in the experimental sleep restriction study. These findings suggest that prolonged sleep deprivation modifies inflammatory and cholesterol pathways at the level of gene expression and serum lipoproteins, inducing changes toward potentially higher risk for cardiometabolic diseases.fi_FI
dc.language.isoENfi_FI
dc.publisherNature Publishing Groupfi_FI
dc.relation.ispartofseriesScientific Reports
dc.relation.urihttp://doi.org/10.1038/srep24828fi_FI
dc.rightsCC BY 4.0 https://creativecommons.org/licenses/by/4.0/fi_FI
dc.subjectChronic inflammationfi_FI
dc.subjectDyslipidaemiasfi_FI
dc.subjectEpidemiologyfi_FI
dc.subjectGene expressionfi_FI
dc.subjectSleep deprivationfi_FI
dc.titleProlonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responsesfi_FI
dc.typehttp://purl.org/eprint/type/JournalArticle
dc.description.versionpublisher's pdffi_FI
dc.contributor.departmentFaculty of Health
dc.contributor.departmentSchool of Pharmacy, Activities
uef.solecris.id40229069
eprint.statushttp://purl.org/eprint/status/PeerReviewedfi_FI
dc.type.publicationinfo:eu-repo/semantics/article
dc.rights.accessrights© Authors
uef.citationinfo.issue6
dc.relation.doi10.1038/srep24828
dc.description.reviewstatushttp://purl.org/eprint/status/PeerReviewed
dc.relation.articlenumber24828
dc.relation.issn2045-2322
dc.relation.issue6


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