Sirtuin functions and modulation: from chemistry to the clinic
Tiedosto(t)
Rinnakkaistallenteen versio
published versionPäivämäärä
2016Tekijä(t)
Yksilöllinen tunniste
10.1186/s13148-016-0224-3Metadata
Näytä kaikki kuvailutiedotLisätietoa
Rinnakkaistallenne
Viittaus
Carafa, Vincenzo. Rotili, Dante. Forgione, Mariantonietta. Cuomo, Francesca. Serretiello, Enrica. Hailu, Gebremedhin S. Jarho, Elina. Lahtela-Kakkonen, Maija. Mai, Antonello. Altucci, Lucia. (2016). Sirtuin functions and modulation: from chemistry to the clinic. Clinical Epigenetics, 8 (1) , 61. 10.1186/s13148-016-0224-3.Oikeudet
Tiivistelmä
Sirtuins are NAD+-dependent histone deacetylases regulating important metabolic pathways in prokaryotes and eukaryotes and are involved in many biological processes such as cell survival, senescence, proliferation, apoptosis, DNA repair, cell metabolism, and caloric restriction. The seven members of this family of enzymes are considered potential targets for the treatment of human pathologies including neurodegenerative diseases, cardiovascular diseases, and cancer. Furthermore, recent interest focusing on sirtuin modulators as epigenetic players in the regulation of fundamental biological pathways has prompted increased efforts to discover new small molecules able to modify sirtuin activity. Here, we review the role, mechanism of action, and biological function of the seven sirtuins, as well as their inhibitors and activators.
Avainsanat
Linkki alkuperäiseen julkaisuun
http://doi.org/10.1186/s13148-016-0224-3Julkaisija
Springer NatureKokoelmat
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