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dc.contributor.authorCarafa, Vincenzo
dc.contributor.authorRotili, Dante
dc.contributor.authorForgione, Mariantonietta
dc.contributor.authorCuomo, Francesca
dc.contributor.authorSerretiello, Enrica
dc.contributor.authorHailu, Gebremedhin S
dc.contributor.authorJarho, Elina
dc.contributor.authorLahtela-Kakkonen, Maija
dc.contributor.authorMai, Antonello
dc.contributor.authorAltucci, Lucia
dc.date.accessioned2016-10-03T11:14:44Z
dc.date.available2016-10-03T11:14:44Z
dc.date.issued2016
dc.identifierhttp://doi.org/10.1186/s13148-016-0224-3fi_FI
dc.identifier.citationClinical Epigenetics The official journal of the Clinical Epigenetics Society 2016 8:61 ; DOI: 10.1186/s13148-016-0224-3 ; © Carafa et al. 2016fi_FI
dc.identifier.issn1868-7075
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/135
dc.descriptionArticle
dc.description.abstractSirtuins are NAD+-dependent histone deacetylases regulating important metabolic pathways in prokaryotes and eukaryotes and are involved in many biological processes such as cell survival, senescence, proliferation, apoptosis, DNA repair, cell metabolism, and caloric restriction. The seven members of this family of enzymes are considered potential targets for the treatment of human pathologies including neurodegenerative diseases, cardiovascular diseases, and cancer. Furthermore, recent interest focusing on sirtuin modulators as epigenetic players in the regulation of fundamental biological pathways has prompted increased efforts to discover new small molecules able to modify sirtuin activity. Here, we review the role, mechanism of action, and biological function of the seven sirtuins, as well as their inhibitors and activators.fi_FI
dc.language.isoENfi_FI
dc.publisherSpringer Naturefi_FI
dc.relation.ispartofseriesClinical Epigenetics
dc.relation.urihttp://doi.org/10.1186/s13148-016-0224-3fi_FI
dc.rightsCC BY 4.0 https://creativecommons.org/licenses/by/4.0/
dc.subjectEpigeneticsfi_FI
dc.subjectSirtuinsfi_FI
dc.subjectSIRT modulatorsfi_FI
dc.subjectDrug discoveryfi_FI
dc.subjectCancerfi_FI
dc.subjectNeurodegenerationfi_FI
dc.titleSirtuin functions and modulation: from chemistry to the clinicfi_FI
dc.typehttp://purl.org/eprint/type/JournalArticle
dc.description.versionpublisher's pdffi_FI
dc.contributor.departmentFaculty of Health
dc.contributor.departmentSchool of Pharmacy, Activities
uef.solecris.id40312825
eprint.statushttp://purl.org/eprint/status/PeerReviewedfi_FI
dc.type.publicationinfo:eu-repo/semantics/article
dc.rights.accessrights© Authors
dc.relation.doi10.1186/s13148-016-0224-3
dc.description.reviewstatushttp://purl.org/eprint/status/PeerReviewed
dc.relation.articlenumber61
dc.relation.issn1868-7075
dc.relation.issue1
dc.relation.volume8
dc.rights.accesslevelopenAccess


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