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dc.contributor.authorBeaney Katherine E
dc.contributor.authorCooper Jackie A
dc.contributor.authorMcLachlan Stela
dc.contributor.authorWannamethee S Goya
dc.contributor.authorJefferis Barbara J
dc.contributor.authorWhincup Peter
dc.contributor.authorBen-Shlomo Yoav
dc.contributor.authorPrice Jacqueline F
dc.contributor.authorKumari Meena
dc.contributor.authorWong Andrew
dc.contributor.authorOng Ken
dc.contributor.authorHardy Rebecca
dc.contributor.authorKuh Diana
dc.contributor.authorKivimaki Mika
dc.contributor.authorKangas Antti J
dc.contributor.authorSoininen Pasi
dc.contributor.authorAla-Korpela Mika
dc.contributor.authorDrenos Fotios
dc.contributor.authorHumphries Steve E; UCLEB consortium
dc.date.accessioned2016-10-11T07:25:09Z
dc.date.available2016-10-11T07:25:09Z
dc.date.issued2016
dc.identifier10.1186/s12933-016-0435-0fi_FI
dc.identifier.citationAPA Beaney, K. E., Cooper, J. A., McLachlan, S., Wannamethee, S. G., Jefferis, B. J., Whincup, P., … on behalf of the UCLEB consortium. (2016). Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids. Cardiovascular Diabetology, 15(1), 115. http://doi.org/10.1186/s12933-016-0435-0fi_FI
dc.identifier.issn1475-2840
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/147
dc.descriptionArticle
dc.description.abstractAims An intergenic locus on chromosome 1 (lead SNP rs10911021) was previously associated with coronary heart disease (CHD) in type 2 diabetes (T2D). Using data from the UCLEB consortium we investigated the relationship between rs10911021 and CHD in T2D, whether rs10911021 was associated with levels of amino acids involved in the γ-glutamyl cycle or any conventional risk factors (CRFs) for CHD in the T2D participants. Methods Four UCLEB studies (n = 6531) had rs10911021 imputation, CHD in T2D, CRF and metabolomics data determined using a nuclear magnetic resonance based platform. Results The expected direction of effect between rs10911021 and CHD in T2D was observed (1377 no CHD/160 CHD; minor allele OR 0.80, 95 % CI 0.60–1.06) although this was not statistically significant (p = 0.13). No association between rs10911021 and CHD was seen in non-T2D participants (11218 no CHD/1274 CHD; minor allele OR 1.00 95 % CIs 0.92–1.10). In T2D participants, while no associations were observed between rs10911021 and the nine amino acids measured, rs10911021 was associated with HDL-cholesterol (p = 0.0005) but the minor “protective” allele was associated with lower levels (−0.034 mmol/l per allele). Focusing more closely on the HDL-cholesterol subclasses measured, we observed that rs10911021 was associated with six large HDL particle measures in T2D (all p < 0.001). No significant associations were seen in non-T2D subjects. Conclusions Our findings are consistent with a true association between rs10911021 and CHD in T2D. The protective minor allele was associated with lower HDL-cholesterol and reductions in HDL particle traits. Our results indicate a complex relationship between rs10911021 and CHD in T2D.fi_FI
dc.language.isoENfi_FI
dc.publisherBioMed Central Ltd.fi_FI
dc.relation.ispartofseriesCARDIOVASCULAR DIABETOLOGY [ONLINE: HTTP://WWW.CARDIAB.COM/]
dc.relation.urihttp://dx.doi.org/10.1186/s12933-016-0435-0fi_FI
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/
dc.subjectCoronary heart diseasefi_FI
dc.subjectMetabolomicsfi_FI
dc.subjectHDL-cholesterolfi_FI
dc.subjectGenetic riskfi_FI
dc.titleVariant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acidsfi_FI
dc.typehttp://purl.org/eprint/type/JournalArticle
dc.description.versionPublisher's pdffi_FI
dc.contributor.departmentFaculty of Health Sciences
dc.contributor.departmentSchool of Pharmacy, Activities
uef.solecris.id42043286
eprint.statushttp://purl.org/eprint/status/PeerReviewedfi_FI
dc.type.publicationinfo:eu-repo/semantics/article
dc.rights.accessrights© Authors
dc.relation.doi10.1186/s12933-016-0435-0
dc.description.reviewstatushttp://purl.org/eprint/status/PeerReviewed
dc.relation.articlenumber115
dc.relation.issn1475-2840
dc.relation.volume15
dc.rights.accesslevelopenAccess


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