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    • Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2 

      Hangas, Anu; Aasumets, Koit; Kekäläinen, Nina J; Paloheinä, Mika; Pohjoismäki, Jaakko L; Gerhold, Joachim M; Goffart, Steffi (Oxford University Press (OUP), 2018)
      Maintenance of topological homeostasis is vital for gene expression and genome replication in all organisms. Similar to other circular genomes, also mitochondrial DNA (mtDNA) is known to exist in various different topological ...