Browsing Luonnontieteiden, metsätieteiden ja tekniikan tiedekunta by Author "Hynynen, Kullervo"

Now showing items 1-4 of 4

    • Blood-brain barrier opening in Alzheimer's disease using MR-guided focused ultrasound 

      Lipsman, Nir; Meng, Ying; Bethune, Allison J; Huang, Yuexi; Lam, Benjamin; Masellis, Mario; Herrmann, Nathan; Heyn, Chinthaka; Aubert, Isabelle; Boutet, Alexandre; Smith, Gwenn S; Hynynen, Kullervo; Black, Sandra E (Springer Nature, 2018)
      Magnetic resonance-guided focused ultrasound in combination with intravenously injected microbubbles has been shown to transiently open the blood–brain barrier, and reduce beta-amyloid and tau pathology in animal models ...
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    • Preliminary Investigation of Focused Ultrasound-Facilitated Drug Delivery for the Treatment of Leptomeningeal Metastases 

      O'Reilly, Meaghan A; Chinnery, Tricia; Yee, My-Linh; Wu, Sheng-Kai; Hynynen, Kullervo; Kerbel, Robert S; Czarnota, Gregory J; Pritchard, Kathleen I: Sahgal, Arjun (Springer Nature, 2018)
      Leptomeningeal metastases (LM) are a serious complication of cancer in the central nervous system (CNS) and are diagnosed in approximately 5% of patients with solid tumors. Effective treatment using systemically administered ...
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    • Three-dimensional transcranial microbubble imaging for guiding volumetric ultrasound-mediated blood-brain barrier opening 

      Jones, Ryan M; Deng, Lulu; Leung, Kogee; McMahon, Dallan; O'Reilly, Meaghan A; Hynynen, Kullervo (Ivyspring International Publisher, 2018)
      Focused ultrasound (FUS)-mediated blood-brain barrier (BBB) opening recently entered clinical testing for targeted drug delivery to the brain. Sources of variability exist in the current procedures, motivating the development ...
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    • Time course of focused ultrasound effects on beta-amyloid plaque pathology in the TgCRND8 mouse model of Alzheimer's disease 

      Poon, Charissa T; Shah, Kairavi; Lin, Chiungting; Tse, Ryan; Kim, Kate K; Mooney, Skyler; Aubert, Isabelle; Stefanovic, Bojana; Hynynen, Kullervo (Springer Nature America, Inc, 2018)
      Previous studies have demonstrated that temporarily increasing the permeability of the blood-brain barrier using focused ultrasound can reduce β-amyloid plaque load and improve cognitive function in animal models of ...
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