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dc.contributor.authorFranke, B
dc.contributor.authorStein, JL
dc.contributor.authorRipke, S
dc.contributor.authorAnttila, V
dc.contributor.authorHibar, DP
dc.contributor.authorvan Hulzen, KJ
dc.contributor.authorArias-Vasquez, A
dc.contributor.authorSmoller, JW
dc.contributor.authorNichols, TE
dc.contributor.authorNeale, MC
dc.contributor.authorMcIntosh, AM
dc.contributor.authorLee, P
dc.contributor.authorMcMahon, FJ
dc.contributor.authorMeyer-Lindenberg, A
dc.contributor.authorMattheisen, M
dc.contributor.authorAndreassen, OA
dc.contributor.authorGruber, O
dc.contributor.authorSachdev, PS
dc.contributor.authorRoiz-Santiañez, R
dc.contributor.authorSaykin, AJ et al
dc.date.accessioned2016-10-11T11:44:56Z
dc.date.available2016-10-11T11:44:56Z
dc.date.issued2016
dc.identifier.citationFranke, B., Stein, J. L., Ripke, S., Anttila, V., Hibar, D. P., van Hulzen, K. J. E., … Sullivan, P. F. (2016). Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof-of-concept and roadmap for future studies. Nature Neuroscience, , 420–431. http://doi.org/10.1038/nn.4228fi_FI
dc.identifier.issn1097-6256
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/154
dc.descriptionArticle
dc.description.abstractSchizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. These results provide a proof of concept (albeit based on a limited set of structural brain measures) and define a roadmap for future studies investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders.fi_FI
dc.language.isoENfi_FI
dc.publisherNature Publishing Groupfi_FI
dc.relation.ispartofseriesNATURE NEUROSCIENCE
dc.relation.urihttp://doi.org/10.1038/nn.4228fi_FI
dc.rightsAll rights reservedfi_FI
dc.subjectschizophreniafi_FI
dc.subjectMRIfi_FI
dc.subjectbrain imagingfi_FI
dc.subjectgeneticsfi_FI
dc.subjectGWASfi_FI
dc.subjectmeta-analysisfi_FI
dc.subjectendophenotypefi_FI
dc.titleGenetic influences on schizophrenia and subcortical brain volumes: large-scale proof of conceptfi_FI
dc.typehttp://purl.org/eprint/type/JournalArticle
dc.description.versionfinal draftfi_FI
dc.contributor.departmentFaculty of Health Sciences
dc.contributor.departmentSchool of Medicine / Clinical Medicine
uef.solecris.id41349556
eprint.statushttp://purl.org/eprint/status/PeerReviewedfi_FI
dc.type.publicationinfo:eu-repo/semantics/article
dc.rights.accessrights© Nature America, Inc.
dc.relation.doi10.1038/nn.4228
dc.description.reviewstatushttp://purl.org/eprint/status/PeerReviewed
dc.relation.issn1097-6256


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