Show simple item record

dc.contributor.authorKoivisto, H
dc.contributor.authorLeinonen, H
dc.contributor.authorPuurula, M
dc.contributor.authorHafes, HS
dc.contributor.authorBarrera, GA
dc.contributor.authorStridh, MH
dc.contributor.authorWaagepetersen, HS
dc.contributor.authorTiainen, M
dc.contributor.authorSoininen, P
dc.contributor.authorZilberter, Y
dc.contributor.authorTanila, H
dc.date.accessioned2016-10-12T10:40:02Z
dc.date.available2016-10-12T10:40:02Z
dc.date.issued2016
dc.identifierhttp://doi.org/10.3389/fnagi.2016.00041fi_FI
dc.identifier.citationKoivisto, H., Leinonen, H., Puurula, M., Hafez, H. S., Barrera, G. A., Stridh, M. H., … Tanila, H. (2016). Chronic Pyruvate Supplementation Increases Exploratory Activity and Brain Energy Reserves in Young and Middle-Aged Mice. Frontiers in Aging Neuroscience, 8, 41. http://doi.org/10.3389/fnagi.2016.00041fi_FI
dc.identifier.issn1663-4365
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/157
dc.descriptionArticle
dc.description.abstractNumerous studies have reported neuroprotective effects of pyruvate when given in systemic injections. Impaired glucose uptake and metabolism are found in Alzheimer’s disease (AD) and in AD mouse models. We tested whether dietary pyruvate supplementation is able to provide added energy supply to brain and thereby attenuate aging- or AD-related cognitive impairment. Mice received ~800 mg/kg/day Na-pyruvate in their chow for 2–6 months. In middle-aged wild-type mice and in 6.5-month-old APP/PS1 mice, pyruvate facilitated spatial learning and increased exploration of a novel odor. However, in passive avoidance task for fear memory, the treatment group was clearly impaired. Independent of age, long-term pyruvate increased explorative behavior, which likely explains the paradoxical impairment in passive avoidance. We also assessed pyruvate effects on body weight, muscle force, and endurance, and found no effects. Metabolic postmortem assays revealed increased energy compounds in nuclear magnetic resonance spectroscopy as well as increased brain glycogen storages in the pyruvate group. Pyruvate supplementation may counteract aging-related behavioral impairment, but its beneficial effect seems related to increased explorative activity rather than direct memory enhancement.fi_FI
dc.language.isoENfi_FI
dc.publisherFrontiers Research Foundationfi_FI
dc.relation.ispartofseriesFrontiers in aging neuroscience;8
dc.relation.urihttp://doi.org/10.3389/fnagi.2016.00041fi_FI
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/fi_FI
dc.titleChronic Pyruvate Supplementation Increases Exploratory Activity and Brain Energy Reserves in Young and Middle-Aged Micefi_FI
dc.typehttp://purl.org/eprint/type/JournalArticle
dc.description.versionPublisher's pdffi_FI
dc.contributor.departmentFaculty of Health Sciences
dc.contributor.departmentA.I. Virtanen Institute / Neurobiology
dc.contributor.departmentSchool of Pharmacy, Activities
uef.solecris.id41377228
eprint.statushttp://purl.org/eprint/status/PeerReviewedfi_FI
dc.type.publicationinfo:eu-repo/semantics/article
dc.rights.accessrights© Authors
dc.relation.doi10.3389/fnagi.2016.00041
dc.description.reviewstatushttp://purl.org/eprint/status/PeerReviewed
dc.relation.issn1663-4365


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record