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dc.contributor.authorTapiainen V
dc.contributor.authorHartikainen S
dc.contributor.authorTaipale H
dc.contributor.authorTiihonen J
dc.contributor.authorTolppanen A-M
dc.date.accessioned2017-04-12T07:17:00Z
dc.date.available2017-04-12T07:17:00Z
dc.date.issued2017
dc.identifier10.1016/j.eurpsy.2017.02.486fi_FI
dc.identifier.issn0924-9338
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/1581
dc.descriptionArticle
dc.description.abstractBackground Studies investigating psychiatric disorders as Alzheimer's disease (AD) risk factors have yielded heterogeneous findings. Differences in time windows between the exposure and outcome could be one explanation. We examined whether (1) mental and behavioral disorders in general or (2) specific mental and behavioral disorder categories increase the risk of AD and (3) how the width of the time window between the exposure and outcome affects the results. Methods A nationwide nested case-control study of all Finnish clinically verified AD cases, alive in 2005 and their age, sex and region of residence matched controls (n of case-control pairs 27,948). History of hospital-treated mental and behavioral disorders was available since 1972. Results Altogether 6.9% (n = 1932) of the AD cases and 6.4% (n = 1784) of controls had a history of any mental and behavioral disorder. Having any mental and behavioral disorder (adjusted OR = 1.07, 95% CI = 1.00–1.16) or depression/other mood disorder (adjusted OR = 1.17, 95% CI = 1.05–1.30) were associated with higher risk of AD with 5-year time window but not with 10-year time window (adjusted OR, 95% CI 0.99, 0.91–1.08 for any disorder and 1.08, 0.96–1.23 for depression). Conclusions The associations between mental and behavioral disorders and AD were modest and dependent on the time window. Therefore, some of the disorders may represent misdiagnosed prodromal symptoms of AD, which underlines the importance of proper differential diagnostics among older persons. These findings also highlight the importance of appropriate time window in psychiatric and neuroepidemiology research.fi_FI
dc.language.isoengfi_FI
dc.publisherElsevier BVfi_FI
dc.relation.ispartofseriesEUROPEAN PSYCHIATRY: THE JOURNAL OF THE ASSOCIATION OF EUROPEAN PSYCHIATRISTS;
dc.relation.urihttp://dx.doi.org/10.1016/j.eurpsy.2017.02.486fi_FI
dc.rightsCC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/fi_FI
dc.subjectAddictionfi_FI
dc.subjectconsumption/abuse/dependencefi_FI
dc.subjectAffective disordersfi_FI
dc.subjectAnxiety disordersfi_FI
dc.subjectSchizophrenia and psychosisfi_FI
dc.subjectAlzheimer diseasefi_FI
dc.subjectEpidemiologyfi_FI
dc.titleHospital-treated mental and behavioral disorders and risk of Alzheimer's disease: A nationwide nested case-control studyfi_FI
dc.typehttp://purl.org/eprint/type/JournalArticle
dc.description.versionfinal draftfi_FI
dc.contributor.departmentSchool of Pharmacy, Activities
dc.contributor.departmentSchool of Medicine / Clinical Medicine
uef.solecris.id46437460
eprint.statushttp://purl.org/eprint/status/PeerReviewedfi_FI
dc.type.publicationinfo:eu-repo/semantics/article
dc.rights.accessrights© Elsevier BVfi_FI
uef.citationinfo.pages92-98
dc.relation.doi10.1016/j.eurpsy.2017.02.486
dc.description.reviewstatushttp://purl.org/eprint/status/PeerReviewed
dc.format.pagerange92-98
dc.relation.issn0924-9338
dc.relation.issueVolume 43, June 2017
dc.relation.volume43


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