Serum Levels of Soluble Urokinase Plasminogen Activator Receptor Are Elevated in Severe Pre-Eclampsia
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CitationJalkanen V. Tihtonen K. Jalkanen K. Jalkanen AJ. Uotila J. Karlsson S. (2016). Serum Levels of Soluble Urokinase Plasminogen Activator Receptor Are Elevated in Severe Pre-Eclampsia. Journal of Clinical Gynecology and Obstetrics, 5 (4) , 101-105. 10.14740/jcgo418w.
Background: Soluble urokinase plasminogen activator receptor (suPAR) is a novel marker for systemic inflammation both in infectious and in inflammatory diseases. Since pathophysiology of pre-eclampsia has been found to include impairment of maternal immune system, we wanted to explore serum level of suPAR in women with severe pre-eclampsia and whether it differs from healthy pregnancies and non-pregnant women.
Methods: Serum samples of suPAR concentrations were analyzed from 10 patients with severe pre-eclampsia, 10 patients with uncomplicated pregnancies and 10 non-pregnant women. SuPAR concentrations were analyzed with enzyme-linked immune-sorbent assay (ELISA).
Results: SuPAR levels were significantly higher in pre-eclampsia 3.5 ng/mL (2.4 - 4.8 ng/mL) compared to healthy pregnancy 2.0 ng/mL (1.7 - 2.6 ng/mL) (P =0.008) or non-pregnant women 2.3 ng/mL (1.9 - 2.9 ng/mL) (P = 0.015). Meanwhile, suPAR concentrations in healthy pregnant patients did not differ from non-pregnant women (P = 0.211).
Conclusions: Serum suPAR levels are elevated in patients with severe pre-eclampsia implying that the systemic inflammatory response is enhanced in severe pre-eclampsia.