Show simple item record

dc.contributor.authorJalkanen V
dc.contributor.authorTihtonen K
dc.contributor.authorJalkanen K
dc.contributor.authorJalkanen AJ
dc.contributor.authorUotila J
dc.contributor.authorKarlsson S
dc.date.accessioned2017-04-12T11:04:36Z
dc.date.available2017-04-12T11:04:36Z
dc.date.issued2016
dc.identifier10.14740/jcgo418wfi_FI
dc.identifier.issn1927-1271
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/1583
dc.descriptionArticle
dc.description.abstractBackground: Soluble urokinase plasminogen activator receptor (suPAR) is a novel marker for systemic inflammation both in infectious and in inflammatory diseases. Since pathophysiology of pre-eclampsia has been found to include impairment of maternal immune system, we wanted to explore serum level of suPAR in women with severe pre-eclampsia and whether it differs from healthy pregnancies and non-pregnant women. Methods: Serum samples of suPAR concentrations were analyzed from 10 patients with severe pre-eclampsia, 10 patients with uncomplicated pregnancies and 10 non-pregnant women. SuPAR concentrations were analyzed with enzyme-linked immune-sorbent assay (ELISA). Results: SuPAR levels were significantly higher in pre-eclampsia 3.5 ng/mL (2.4 - 4.8 ng/mL) compared to healthy pregnancy 2.0 ng/mL (1.7 - 2.6 ng/mL) (P =0.008) or non-pregnant women 2.3 ng/mL (1.9 - 2.9 ng/mL) (P = 0.015). Meanwhile, suPAR concentrations in healthy pregnant patients did not differ from non-pregnant women (P = 0.211). Conclusions: Serum suPAR levels are elevated in patients with severe pre-eclampsia implying that the systemic inflammatory response is enhanced in severe pre-eclampsia.fi_FI
dc.language.isoENGfi_FI
dc.publisherElmer Pressfi_FI
dc.relation.ispartofseriesJournal of Clinical Gynecology and Obstetrics
dc.relation.urihttp://doi.org/10.14740/jcgo418wfi_FI
dc.rightsCC BY-NC https://creativecommons.org/licenses/by-nc/4.0/fi_FI
dc.subjectSoluble urokinase plasminogen activator receptorfi_FI
dc.subjectPreeclampsiafi_FI
dc.subjectGestational hypertensionfi_FI
dc.titleSerum Levels of Soluble Urokinase Plasminogen Activator Receptor Are Elevated in Severe Pre-Eclampsiafi_FI
dc.typehttp://purl.org/eprint/type/JournalArticle
dc.description.versionPublisher's pdffi_FI
dc.contributor.departmentSchool of Pharmacy, Activities
uef.solecris.id46355773
eprint.statushttp://purl.org/eprint/status/PeerReviewedfi_FI
dc.type.publicationinfo:eu-repo/semantics/article
dc.rights.accessrights© The Authorsfi_FI
uef.citationinfo.pages101-105
dc.relation.doi10.14740/jcgo418w
dc.description.reviewstatushttp://purl.org/eprint/status/PeerReviewed
dc.format.pagerange101-105
dc.relation.issn1927-1271
dc.relation.issue4
dc.relation.volume5


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record