dc.contributor.author | Jalkanen V | |
dc.contributor.author | Tihtonen K | |
dc.contributor.author | Jalkanen K | |
dc.contributor.author | Jalkanen AJ | |
dc.contributor.author | Uotila J | |
dc.contributor.author | Karlsson S | |
dc.date.accessioned | 2017-04-12T11:04:36Z | |
dc.date.available | 2017-04-12T11:04:36Z | |
dc.date.issued | 2016 | |
dc.identifier | 10.14740/jcgo418w | fi_FI |
dc.identifier.issn | 1927-1271 | |
dc.identifier.uri | https://erepo.uef.fi/handle/123456789/1583 | |
dc.description | Article | |
dc.description.abstract | Background: Soluble urokinase plasminogen activator receptor (suPAR) is a novel marker for systemic inflammation both in infectious and in inflammatory diseases. Since pathophysiology of pre-eclampsia has been found to include impairment of maternal immune system, we wanted to explore serum level of suPAR in women with severe pre-eclampsia and whether it differs from healthy pregnancies and non-pregnant women.
Methods: Serum samples of suPAR concentrations were analyzed from 10 patients with severe pre-eclampsia, 10 patients with uncomplicated pregnancies and 10 non-pregnant women. SuPAR concentrations were analyzed with enzyme-linked immune-sorbent assay (ELISA).
Results: SuPAR levels were significantly higher in pre-eclampsia 3.5 ng/mL (2.4 - 4.8 ng/mL) compared to healthy pregnancy 2.0 ng/mL (1.7 - 2.6 ng/mL) (P =0.008) or non-pregnant women 2.3 ng/mL (1.9 - 2.9 ng/mL) (P = 0.015). Meanwhile, suPAR concentrations in healthy pregnant patients did not differ from non-pregnant women (P = 0.211).
Conclusions: Serum suPAR levels are elevated in patients with severe pre-eclampsia implying that the systemic inflammatory response is enhanced in severe pre-eclampsia. | |
dc.language.iso | ENG | |
dc.publisher | Elmer Press | |
dc.relation.ispartofseries | Journal of Clinical Gynecology and Obstetrics | |
dc.relation.uri | http://doi.org/10.14740/jcgo418w | |
dc.rights | CC BY-NC 4.0 | |
dc.subject | Soluble urokinase plasminogen activator receptor | |
dc.subject | Preeclampsia | |
dc.subject | Gestational hypertension | |
dc.title | Serum Levels of Soluble Urokinase Plasminogen Activator Receptor Are Elevated in Severe Pre-Eclampsia | |
dc.type | http://purl.org/eprint/type/JournalArticle | |
dc.description.version | published version | |
dc.contributor.department | School of Pharmacy, Activities | |
uef.solecris.id | 46355773 | en |
eprint.status | http://purl.org/eprint/status/PeerReviewed | fi_FI |
dc.type.publication | info:eu-repo/semantics/article | |
uef.citationinfo.pages | 101-105 | |
dc.relation.doi | 10.14740/jcgo418w | |
dc.description.reviewstatus | peerReviewed | |
dc.format.pagerange | 101-105 | |
dc.relation.issn | 1927-1271 | |
dc.relation.issue | 4 | |
dc.relation.volume | 5 | |
dc.rights.accesslevel | openAccess | |
dc.type.okm | A1 | |
uef.solecris.openaccess | Ei | |
dc.rights.copyright | © 2016 The Authors | |
dc.type.displayType | Artikkeli | fi |
dc.type.displayType | Article | en |
uef.rt.id | 1806 | en |
dc.rights.url | https://creativecommons.org/licenses/by-nc/4.0/ | |