Terveystieteiden tiedekunta
Recent Submissions
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HIV in Sunyani and peri-urban areas is associated with previous history of syphilis infection and multiple sexual partners - A cross-sectional study
(University of Ghana College of Health Sciences, 2024)Background: The Bono Region of Ghana has consistently recorded increase in HIV prevalence over the years with an average prevalence of 3.4% in the recent HIV survey. Sunyani, the capital Region of Bono recorded an HIV ...
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Impact of High-Pressure Processing on Quality and Safety of High-Oil-Content Pesto Sauce: A Comparative Study with Thermal Processing
(MDPI, 2024)High-pressure processing (HPP) is a promising technology for increasing the shelf life of food, with minimal effects on the nutritional or sensory quality. However, there has been a concern that high-oil-content foods may ...
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Genetic variation drives differences in obesity-related gene regulation
(Elsevier Ltd, 2024)Heikkinen and colleagues recently demonstrated that genetic variation, rather than dietary changes, governs gene regulation in liver. This finding highlights the impact of noncoding variants on chromatin accessibility, ...
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Coronary Artery Disease Risk Variant Dampens the Expression of CALCRL by Reducing HSF Binding to Shear Stress Responsive Enhancer in Endothelial Cells in Vitro
(Ovid Technologies, Inc, 2024)BACKGROUND: CALCRL (calcitonin receptor-like) protein is an important mediator of the endothelial fluid shear stress response, which is associated with the genetic risk of coronary artery disease. In this study, we ...
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Induced Pluripotent Stem Cell-Derived Microglia to Study Nlrp3 Inflammasome Activation in Alzheimer’s Disease
(Istanbul University Press, 2024)Objective: Alzheimer’s disease (AD) is an irreversible and progressive neurodegenerative disease. Besides amyloid beta (Aβ) and tau accumulations, inflammation also contributes to AD pathogenesis. NLR family pyrin domain ...
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Women’s perspectives on the acceptability of risk-based cervical cancer screening
(Springer Nature Limited, 2024)Background The increased knowledge of cervical cancer (CC) risk factors and suboptimal performance of present screening programs has generated interest in shifting from a universal screening approach to one based on ...
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Bioavailability and interactions of schisandrin B with 5-fluorouracil in a xenograft mouse model of colorectal cancer
(Elsevier Ltd, 2025)Schisandrin B (Sch B) is a predominant bioactive lignan from the fruit of a Chinese medicine food homology plant, Schisandra chinensis. Previously, we observed potent anti-tumor effect of Sch-B in colorectal cancer (CRC) ...
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Longitudinal Left Ventricular Mass Indexing for DEXA-Measured Lean Mass and Fat Mass: Normative Reference Centiles in Post-Pubertal Adolescents and Young Adults
(The American Physiological Society, 2023)Left ventricular (LV) hypertrophy derived from LV mass (LVM) cut point is a marker of cardiovascular events in adults and target organ damage in pediatric research. Inadequate LVM indexing for body size due to scarcity of ...
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The mineralocorticoid receptor in diabetic kidney disease
(The American Physiological Society, 2024)Diabetes mellitus is one of the leading causes of chronic kidney disease and its progression to end-stage kidney disease (ESKD). Diabetic kidney disease (DKD) is characterized by glomerular hypertrophy, hyperfiltration, ...
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Estrogen and cardiovascular disease
(Elsevier Inc, 2024)A large body of scientific research accumulated over the past twenty years documents the cardiovascular (CV) benefits of estradiol (E2) and progesterone (P4) in reproductive aged women. In contrast, accelerated development ...
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Screening for Calcifying Nanoparticles in Dermatological Diseases
(CMJ Publishers, 2024)
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Diagnostic challenge of an untypical cutaneous drug reaction from modafinil
(John Wiley & Sons Ltd, 2024)Modafinil used for narcolepsy caused an atypical adverse reaction, as itchy acneiform lesions, subcutaneous nodules and superficial skin wounds after 2 years of use. After extensive examinations for 5 years, modafinil was ...
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Challenging treatment of keloid scars: a case report
(JLE, 2024)
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Beyond KRAS(G12C): Biochemical and Computational Characterization of Sotorasib and Adagrasib Binding Specificity and the Critical Role of H95 and Y96
(American Chemical Society, 2024)Mutated KRAS proteins are frequently expressed in some of the most lethal human cancers and thus have been a target of intensive drug discovery efforts for decades. Lately, KRAS(G12C) switch-II pocket (SII–P)-targeting ...
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Sosiaali- ja terveysalan opettajien työhyvinvointi ja sitä edistävät tekijät – poikkileikkaustutkimus Suomessa 2020
(Hoitotieteiden tutkimusseura HTTS r.y, 2023)Sosiaali- ja terveysalan opettajilla työhyvinvoinnin ylläpitäminen ja edistäminen on entistä merkityksellisempää työnhallinnan haasteiden kasvaessa ja henkilöstön ikääntyessä. Tämän tutkimuksen tarkoituksena oli kuvata sosiaali- ...
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Eight-year Diet and Physical Activity Intervention Affects Serum Metabolites during Childhood & Adolescence: A Nonrandomized Controlled Trial
(Elsevier Inc, 2024)Long-term lifestyle interventions in childhood and adolescence can significantly improve cardiometabolic health, but the underlying molecular mechanisms remain poorly understood. To address this knowledge gap, we conducted ...
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Technical Validation and Utility of an HLA Class II Tetramer Assay for Type 1 Diabetes: A Multicenter Study
(Oxford University Press on behalf of the Endocrine Society, 2024)Context Validated assays to measure autoantigen-specific T-cell frequency and phenotypes are needed for assessing the risk of developing diabetes, monitoring disease progression, evaluating responses to treatment, and ...
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Temporal Alterations in CD8+ T Cells During the Progression from Stage 1 to Stage 3 Type 1 Diabetes
(American Diabetes Association, 2024)CD8+ T cells are perceived to play a major role in the pathogenesis of type 1 diabetes (T1D). In this study, we characterized the function and phenotype of circulating CD8+ memory T cells in samples from individuals at ...
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Avoidant-restrictive food intake disorder and autism: epidemiology, etiology, complications, treatment, and outcome
(Wolters Kluwer Health, Inc, 2023)Purpose of review There is considerable overlap between the features of avoidant-restrictive food intake disorder (ARFID) and autism. The purpose of this scoping review is to provide an overview of studies published on ...
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Multiplicative, additive, and interactive associations of 25-hydroxyvitamin D with lung and prostate cancer
(Hogrefe, 2023)Results regarding the epidemiological association of vitamin D with lung (LCA) and prostate cancer (PCA) are controversial. This study tested whether serum 25-hydroxyvitamin D [25(OH)D] concentrations have interactive ...
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