Now showing items 156-175 of 1362

    • Barriers and Facilitators to Cervical Screening among Migrant Women of African Origin: A Qualitative Study in Finland 

      Idehen, Esther E; Pietilä, Anna-Maija; Kangasniemi, Mari (MDPI AG, 2020)
      Globally, cervical cancer constitutes a substantial public health concern. Evidence recommends regular cervical cancer screening (CCS) for early detection of “precancerous lesions.”Understanding the factors influencing ...
      Tieteelliset aikakauslehtiartikkelit

    • Baseline Telomere Length and Effects of a Multidomain Lifestyle Intervention on Cognition: The FINGER Randomized Controlled Trial 

      Sindi Shireen; Ngandu Tiia; Hovatta Iiris; Kåreholt Ingemar; Antikainen Riitta; Hänninen Tuomo; Levälahti Esko; Laatikainen Tiina; Lindström Jaana; Paajanen Teemu; Peltonen Markku; Khalsa Dharma Singh; Wolozin Benjamin; Strandberg Timo; Tuomilehto Jaakko; Soininen Hilkka; Kivipelto Miia; Solomon Alina (IOS Press, 2017)
      Leukocyte telomere length (LTL) is a biomarker of aging, and it is associated with lifestyle. It is currently unknown whether LTL is associated with the response to lifestyle interventions. The goal is to assess whether ...

    • Bayesian Network Model to Evaluate the Effectiveness of Continuous Positive Airway Pressure Treatment of Sleep Apnea 

      Ryynänen, Olli-Pekka; Leppänen, Timo; Kekolahti, Pekka; Mervaala, Esa; Töyräs, Juha (The Korean Society of Medical Informatics (KAMJE), 2018)
      Objectives The association between obstructive sleep apnea (OSA) and mortality or serious cardiovascular events over a long period of time is not clearly understood. The aim of this observational study was to estimate the ...
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    • Behavioral outcome measures to improve experimental stroke research 

      Balkaya, Mustafa G; Trueman, Rebecca C; Boltze, Johannes; Corbett, Dale; Jolkkonen, Jukka (Elsevier BV, 2018)
      Functional recovery after an experimental stroke can be assessed by multiple behavioral tests, however, there is no consensus about which test to use in long-term stroke recovery studies or whether the tests are affected ...
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    • Beneficial Effects of Regular Physical Exercises on Mental State in Visually Impaired and Deaf-blind Adults 

      Surakka Airi; Venojärvi Mika; Pitkänen Kauko (Horizon Research Publishing Corporation, 2016)
      The most common mental health problems in visually impaired and deaf-blind adults are depression, anxiety, tension, difficulties in falling asleep and disturbed sleep. The physical training program used in this study was ...

    • Benefits of switching from latanoprost to preservative-free tafluprost eye drops: a meta-analysis of two Phase IIIb clinical trials 

      Uusitalo, Hannu; Egorov, Evjeniy; Kaarniranta, Kai; Astakhov, Yuri; Ropo, Auli (Dove Medical Press Ltd., 2016)
      Introduction: Glaucoma patients frequently exhibit ocular surface side effects during treatment with prostaglandin eye drops. The present work investigated whether glaucoma patients suffering from signs and symptoms of ...

    • Benzenesulphonamide inhibitors of the cytolytic protein perforin 

      Spicer Julie A; Miller Christian K; O'Connor Patrick D; Jose Jiney; Huttunen Kristiina M; Jaiswal Jagdish K; Denny William A; Akhlaghi Hedieh; Browne Kylie A (Elsevier BV, 2017)
      The pore-forming protein perforin is a key component of mammalian cell-mediated immunity and essential to the pathway that allows elimination of virus-infected and transformed cells. Perforin activity has also been implicated ...

    • Big data sharing and analysis to advance research in post-traumatic epilepsy 

      Duncan, Dominique; Vespa, Paul; Pitkanen, Asla; Braimah, Adebayo; Lapinlampi, Niina; Toga, Arthur W (Elsevier BV, 2019)
      We describe the infrastructure and functionality for a centralized preclinical and clinical data repository and analytic platform to support importing heterogeneous multi-modal data, automatically and manually linking data ...
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    • Binding Affinity via Docking: Fact and Fiction 

      Pantsar, Tatu; Poso, Antti (MDPI AG, 2018)
      In 1982, Kuntz et al. published an article with the title “A Geometric Approach to Macromolecule-Ligand Interactions”, where they described a method “to explore geometrically feasible alignment of ligands and receptors of ...
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    • Biodegradable coronary scaffolds - their future and clinical and technological challenges 

      Hytönen, Jarkko P; Taavitsainen, Jouni; Tarvainen, Santeri; Ylä-Herttuala, Seppo (Oxford University Press (OUP), 2018)
      Angioplasty and stenting are standard treatment options for both stabile occlusive coronary artery disease and acute myocardial infarctions. Over the last years, several biodegradable stent systems have entered pre-clinical ...
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    • Biological interpretation of genome-wide association studies using predicted gene functions 

      Pers, Tune H.; Karjalainen, Juha M.; Chan, Yingleong; Westra, Harm-Jan; Wood, Andrew R.; Yang, Jian; Lui, Julian C.; Vedantam, Sailaja; Gustafsson, Stefan; Esko, Tonu; Frayling, Tim; Speliotes, Elizabeth K.; Boehnke, Michael; Raychaudhuri, Soumya; Fehrmann, Rudolf S. N.; Hirschhorn, Joel N.; Franke, Lude; Kuusisto, Johanna (Nature Publishing Group, 2015)
      The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions ...

    • The biomarker and causal roles of homoarginine in the development of cardiometabolic diseases: an observational and Mendelian randomization analysis 

      Seppälä I; Oksala N; Jula A; Kangas AJ; Soininen P; Hutri-Kähönen N; März W; Meinitzer A; Juonala M; Kähönen M; Raitakari OT; Lehtimäki T (Springer Nature, 2017)
      High L-homoarginine (hArg) levels are directly associated with several risk factors for cardiometabolic diseases whereas low levels predict increased mortality in prospective studies. The biomarker role of hArg in young ...

    • Biomarker counselling, disclosure of diagnosis and follow-up in patients with mild cognitive impairment: A European Alzheimer's Disease Consortium survey 

      Frederiksen, Kristian Steen; Nielsen, T Rune; Appollonio, Ildebrando; Andersen, Birgitte Bo; Riverol, Mario; Boada, Mercè; Ceccaldi, Mathieu; Dubois, Bruno; Engelborghs, Sebastiaan; Frölich, Lutz; Hausner, Lucrezia; Gabelle, Audrey; Gabryelewicz, Tomasz; Grimmer, Timo; Hanseeuw, Bernard; Hort, Jakub; Hugon, Jacques; Jelic, Vesna; Koivisto, Anne; Kramberger, Milica G; (Wiley, 2021)
      Objectives Mild cognitive impairment (MCI) is associated with an increased risk of further cognitive decline, partly depending on demographics and biomarker status. The aim of the present study was to survey the clinical ...
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    • Biomarkers For Epileptogenesis And Its Treatment 

      Engel, Jerome Jr; Pitkänen, Asla (Elsevier BV, 2020)
      There are no pharmacological interventions to prevent the development of epilepsy, although many promising compounds have been identified in the animal laboratory. Clinical trials to validate their effectiveness, however, ...
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    • Biometeorological assessment of mortality related to extreme temperatures in Helsinki Region, Finland, 1972-2014 

      Ruuhela Reija; Jylhä Kirsti; Lanki Timo; Tiittanen Pekka; Matzarakis Andreas (MDPI AG, 2017)
      Climate change is expected to increase heat-related and decrease cold-related mortality. The extent of acclimatization of the population to gradually-changing thermal conditions is not well understood. We aimed to define ...

    • Birth size and gestational age in opposite-sex twins as compared to same-sex twins: An individual-based pooled analysis of 21 cohorts 

      Jelenkovic, A; Sund, R; Yokoyama, Y; Hur, YM; Ullemar, V; Almqvist, C; Magnusson, PK; Willemsen, G; Bartels, M; Beijsterveldt, CEV; Bogl, LH; Pietiläinen, KH; Vuoksimaa, E; Ji, F; Ning, F; Pang, Z; Nelson, TL; Whitfield, KE; Rebato, E; Llewellyn, CH; et al (Springer Nature, 2018)
      It is well established that boys are born heavier and longer than girls, but it remains unclear whether birth size in twins is affected by the sex of their co-twin. We conducted an individual-based pooled analysis of 21 ...
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    • Birth size, body composition, and adrenal androgens as determinants of bone mineral density in mid-childhood 

      Nordman, Henrikki; Voutilainen, Raimo; Laitinen, Tomi; Antikainen, Leena; Jääskeläinen, Jarmo (Springer Nature, 2018)
      Background Birth weight has an impact on adult bone mass. Higher birth weight is associated with greater bone mineral content (BMC) and children born small for gestational age (SGA) are at an increased risk for impaired ...
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    • Birth weight is associated with dietary factors at the age of 6–8 years: the Physical Activity and Nutrition in Children (PANIC) study 

      Eloranta, AM; Jääskeläinen, J; Venäläinen, T; Jalkanen, H; Kiiskinen, S; Mäntyselkä, A; Schwab, U; Lindi, V; Lakka, TA (Cambridge University Press (CUP), 2018)
      Low and high birth weight have been associated with increased risk of type 2 diabetes and CVD. Diet could partly mediate this association, e.g. by intra-uterine programming of unhealthy food preferences. We examined the ...

    • Blocking oestradiol synthesis pathways with potent and selective coumarin derivatives 

      Niinivehmas, S; Postila, PA; Rauhamäki, S; Manivannan, E; Kortet, S; Ahinko, M; Huuskonen, P; Nyberg, N; Koskimies, P; Lätti, S; Multamäki, E; Juvonen, RO; Raunio, H; Pasanen, M; Huuskonen, J; Pentikäinen, OT (Informa UK Limited, 2018)
      A comprehensive set of 3-phenylcoumarin analogues with polar substituents was synthesised for blocking oestradiol synthesis by 17-β-hydroxysteroid dehydrogenase 1 (HSD1) in the latter part of the sulphatase pathway. Five ...
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    • Blood hsa-miR-122-5p and hsa-miR-885-5p levels associate with fatty liver and related lipoprotein metabolism - The Young Finns Study 

      Raitoharju Emma; Seppälä Ilkka; Lyytikäinen Leo-Pekka; Viikari Jorma; Ala-Korpela Mika; Soininen Pasi; Kangas Antti J; Waldenberger Melanie; Klopp Norman; Illig Thomas; Leiviskä Jaana; Loo Britt-Marie; Oksala Niku; Kähönen Mika; Hutri-Kähönen Nina; Laaksonen Reijo; Raitakari Olli; Lehtimäki Terho (Springer Nature, 2016)
      MicroRNAs are involved in disease development and may be utilized as biomarkers. We investigated the association of blood miRNA levels and a) fatty liver (FL), b) lipoprotein and lipid pathways involved in liver lipid ...