Now showing items 81-100 of 600

    • CAIDE dementia risk score, Alzheimer and cerebrovascular pathology: a population-based autopsy study 

      Hooshmand, B; Polvikoski, T; Kivipelto, M; Tanskanen, M; Myllykangas, L; Mäkelä, M; Oinas, M; Paetau, A; Solomon, A (Wiley-BlackwellBritannia, 2018)
      Background CAIDE Dementia Risk Score is a tool for estimating dementia risk in the general population. Its longitudinal associations with Alzheimer or vascular neuropathology in the oldest old are not known. Aim To ...
    • Camelina Sativa Oil, but not Fatty Fish or Lean Fish, Improves Serum Lipid Profile in Subjects with Impaired Glucose Metabolism - A Randomized Controlled Trial 

      Schwab, Ursula Sonja; Erkkilä, Arja; Kurl, Sudhir; Lankinen, Maria; de Mello Laaksonen, Vanessa (Wiley-BlackwellEN, 2018)
      Scope The aim of the study is to examine whether lean fish (LF), fatty fish (FF), and camelina sativa oil (CSO), a plant-based source of alpha-linolenic acid (ALA), differ in their metabolic effects in subjects with ...
    • Cardiac Actions of a Small Molecule Inhibitor Targeting GATA4-NKX2-5 Interaction 

      Kinnunen, SM; Tölli, M; Välimäki, MJ; Gao, E; Szabo, Z; Rysä, J; Ferreira, MPA; Ohukainen, P; Serpi, R; Correia, A; Mäkilä, E; Salonen, J; Hirvonen, J; Santos, HA; Ruskoaho, H (Springer Nature, 2018)
      Transcription factors are fundamental regulators of gene transcription, and many diseases, such as heart diseases, are associated with deregulation of transcriptional networks. In the adult heart, zinc-finger transcription ...
    • Cardiac repolarization during fingolimod treatment in patients with relapsing-remitting multiple sclerosis 

      Laiho, Aapo; Laitinen, Tiina M; Hartikainen, Paivi; Hartikainen, Juha E K; Laitinen, Tomi P; Simula, Sakari (Wiley-Blackwell, 2018)
      Background Fingolimod is a sphingosine‐1‐phosphate receptor modulator for the treatment of relapsing–remitting multiple sclerosis (RRMS). Despite an established effect on heart rate, the effect of fingolimod on cardiac ...
    • Cardiac repolarization evolves differently during the course of benign and disabling multiple sclerosi 

      Mikkola, Alma; Ojanen, Aku; Hartikainen, Juha EK; Remes, Anne M; Simula, Sakari (Elsevier BV, 2018)
      Background Cardiac repolarization is modulated by the autonomic nervous system. Even though multiple sclerosis associates with prolonged cardiac repolarization the physiology responsible for the phenomenon remains ...
    • Cardiopulmonary Exercise Testing in Pediatrics 

      Takken Tim; Bongers Bart C; van Brussel Marco; Haapala Eero A; Hulzebos Erik HJ (American Thoracic Society, 2017)
      Aerobic fitness is an important determinant of overall health. Higher aerobic fitness has been associated with many health benefits. Because myocardial ischemia is rare in children, indications for exercise testing differ ...
    • Cardiovascular gene therapy : past, present, and future 

      Ylä-Herttuala S; Baker AH (Elsevier BV, 2017)
      Cardiovascular diseases remain a large global health problem. Although several conventional small-molecule treatments are available for common cardiovascular problems, gene therapy is a potential treatment option for ...
    • Career anchors of dentist leaders 

      Tuononen Tiina; Lammintakanen Johanna; Suominen Anna Liisa (Informa UK Limited, 2016)
      Objective: The work of a health care leader is demanding; in order to cope, leaders need motivation and support. The occurrence of intrinsic factors called career anchors (combination of one’s competence, motives and values) ...
    • Career path from a dentist to a leader 

      Tuononen, Tiina A; Suominen, Anna Liisa; Lammintakanen, Johanna (Emerald, 2018)
      Purpose – The purpose of this paper was to study the career paths of leaders with a career background as a dentist from basic degree to chief or executive leadership positions and individual factors that influenced their ...
    • Carotid plaque-thickness and common carotid IMT show additive value in cardiovascular risk prediction and reclassification 

      Amato M; Veglia F; de Faire U; Giral P; Rauramaa R; Smit AJ; Kurl S; Ravani A; Frigerio B; Sansaro D; Bonomi A; Tedesco CC; Castelnuovo S; Mannarino E; Humphries SE; Hamsten A; Tremoli E; Baldassarre D; on behalf of the IMPROVE study group (Elsevier BV, 2017)
      Background and aims Carotid plaque size and the mean common carotid intima-media thickness measured in plaque-free areas (PF CC-IMTmean) have been identified as predictors of vascular events (VEs), but their complementarity ...
    • Case-control analysis of truncating mutations in DNA damage response genes connects TEX15 and FANCD2 with hereditary breast cancer susceptibility 

      Mantere T; Tervasmäki A; Nurmi A; Rapakko K; Kauppila S; Tang J; Schleutker J; Kallioniemi A; Hartikainen JM; Mannermaa A; Nieminen P; Hanhisalo R; Lehto S; Suvanto M; Grip M; Jukkola-Vuorinen A; Tengström M; Auvinen P; Kvist A; Borg Å et al (Springer Nature, 2017)
      Several known breast cancer susceptibility genes encode proteins involved in DNA damage response (DDR) and are characterized by rare loss-of-function mutations. However, these explain less than half of the familial cases. ...
    • Caspase-8, association with Alzheimer's Disease and functional analysis of rare variants 

      Rehker J; Rodhe J; Nesbitt RR; Boyle EA; Martin BK; Lord J; Karaca I; Naj A; Jessen F; Helisalmi S; Soininen H; Hiltunen M; Ramirez A; Scherer M; Farrer LA; Haines JL; Pericak-Vance MA; Raskind WH; Cruchaga C; Schellenberg GD; Joseph B; Brkanac Z (Public Library of Science (PLoS), 2017)
      The accumulation of amyloid beta (Aβ) peptide (Amyloid cascade hypothesis), an APP protein cleavage product, is a leading hypothesis in the etiology of Alzheimer's disease (AD). In order to identify additional AD risk ...
    • Catastrophic health expenditure and impoverishment in Mongolia 

      Dorjdagva, J; Batbaatar, E; Svensson, M; Dorjsuren, B; Kauhanen, J (Springer Nature, 2016)
      Background The social health insurance coverage is relatively high in Mongolia; however, escalation of out-of-pocket payments for health care, which reached 41 % of the total health expenditure in 2011, is a policy concern. ...
    • Cell protrusions induced by hyaluronan synthase 3 (HAS3) resemble mesothelial microvilli and share cytoskeletal features of filopodia 

      Koistinen, Ville; Kärnä, Riikka; Koistinen, Arto; Arjonen, Antti; Tammi, Markku; Rilla, Kirsi (Elsevier BV, 2015-10-01)
      Previous studies have shown that overexpression of enzymatically active GFP-HAS induces the growth of long, slender protrusions that share many features of both filopodia and microvilli. These protrusions are dependent on ...
    • Cellular Senescence in Age-Related Macular Degeneration: Can Autophagy and DNA Damage Response Play a Role? 

      Blasiak Janusz; Piechota Malgorzata; Pawlowska Elzbieta; Szatkowska Magdalena; Sikora Ewa; Kaarniranta Kai (Hindawi Limited, 2017)
      Age-related macular degeneration (AMD) is the main reason of blindness in developed countries. Aging is the main AMD risk factor. Oxidative stress, inflammation and some genetic factors play a role in AMD pathogenesis. AMD ...
    • Ceramide stearic to palmitic acid ratio predicts incident diabetes 

      Hilvo, M; Salonurmi, T; Havulinna, AS; Kauhanen, D; Pedersen, ER; Tell, GS; Meyer, K; Teeriniemi, AM; Laatikainen, T; Jousilahti, P; Savolainen, MJ; Nygård, O; Salomaa, V; Laaksonen, R (Saksa, 2018)
      Aims/hypothesis Ceramide lipids have a role in the development of insulin resistance, diabetes and risk of cardiovascular disease. Here we investigated four ceramides and their ratios to find the best predictors of incident ...
    • Cerebellar Atrophy and Changes in Cytokines Associated with the CACNA1A R583Q Mutation in a Russian Familial Hemiplegic Migraine Type 1 Family 

      Khaiboullina Svetlana F; Mendelevich Elena G; Shigapova Leyla H; Shagimardanova Elena; Gazizova Guzel; Nikitin Alexey; Martynova Ekaterina; Davidyuk Yuriy N; Bogdanov Enver I; Gusev Oleg; van den Maagdenberg Arn MJM; Giniatullin Rashid A; Rizvanov Albert A (Frontiers Media SA, 2017)
      Background: Immune mechanisms recently emerged as important contributors to migraine pathology with cytokines affecting neuronal excitation. Therefore, elucidating the profile of cytokines activated in various forms of ...
    • Cerebrospinal Fluid TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis Patients with and without the C9ORF72 Hexanucleotide Expansion 

      Junttila, A; Kuvaja, M; Hartikainen, P; Siloaho, M; Helisalmi, S; Moilanen, V; Kiviharju, A; Jansson, L; Tienari, PJ; Remes, AM; Herukka, SK (S.Karger AG, 2016)
      Background TDP-43 is the main protein component of ubiquitinated inclusions in a subgroup of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) patients. The C9ORF72 hexanucleotide expansion ...
    • Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline 

      Bos Isabelle; Verhey Frans R; Ramakers Inez HGB; Jacobs Heidi IL; Soininen Hilkka; Freund-Levi Yvonne; Hampel Harald; Tsolaki Magda; Wallin Åsa K; van Buchem Mark A; Oleksik Ania; Verbeek Marcel M; Rikkert Marcel Olde; van der Flier Wiesje M; Scheltens Philip; Aalten Pauline; Visser Pieter Jelle; Vos Stephanie JB (Springer Nature, 2017)
      Background Cerebrovascular disease (CVD) and amyloid-β (Aβ) often coexist, but their influence on neurodegeneration and cognition in predementia stages remains unclear. We investigated the association between CVD and Aβ ...
    • Challenges in evaluation of screening for gastric cancer among men based on nonrandomized design 

      Vohlonen I; Härkönen M; Malila N; Pukkala E; Sipponen P; Koistinen V; Hakama M (Informa UK LimitedBritannia, 2017)
      Background: Objective was to quantify biases in screening for gastric cancer when comparing attenders to nonattenders using serum pepsinogen I (SPGI) level as primary test. Methods: In mid 1990s, all men aged 51–65 years ...