Now showing items 120-139 of 302

    • Gene Expression Mapping of Histone Deacetylases and Co-factors, and Correlation with Survival Time and 1H-HRMAS Metabolomic Profile in Human Gliomas subtitle: 

      Dali-Youcef, Nassim; Froelich, Sébastien; Moussallieh, François-Marie; Chibbaro, Salvatore; Noël, Georges; Namer, Izzie J.; Heikkinen, Sami; Auwerx, Johan (Nature Publishing Group, 2015-03-20)
      Primary brain tumors are presently classified based on imaging and histopathological techniques, which remains unsatisfaying. We profiled here by quantitative real time PCR (qRT-PCR) the transcripts of eighteen histone ...
    • Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept 

      Franke, B; Stein, JL; Ripke, S; Anttila, V; Hibar, DP; van Hulzen, KJ; Arias-Vasquez, A; Smoller, JW; Nichols, TE; Neale, MC; McIntosh, AM; Lee, P; McMahon, FJ; Meyer-Lindenberg, A; Mattheisen, M; Andreassen, OA; Gruber, O; Sachdev, PS; Roiz-Santiañez, R; Saykin, AJ et al (Nature Publishing Group, 2016)
      Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are ...
    • Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children 

      Schnurr TM; Viitasalo A; Eloranta AM; Damsgaard CT; Mahendran Y; Have CT; Väistö J; Hjorth MF; Christensen LB; Brage S; Atalay M; Lyytikäinen LP; Lindi V; Lakka T; Michaelsen KF; Kilpeläinen TO; Hansen T (Springer Nature, 2017)
      Increased sedentariness has been linked to the growing prevalence of obesity in children, but some longitudinal studies suggest that sedentariness may be a consequence rather than a cause of increased adiposity. We used ...
    • Genetic predisposition to ductal carcinoma in situ of the breast 

      Petridis, C; Brook, MN; Shah, V; Kohut, K; Gorman, P; Caneppele, M; Levi, D; Papouli, E; Orr, N; Cox, A; Cross, SS; Dos-Santos-Silva, I; Peto, J; Swerdlow, A; Schoemaker, MJ; Bolla, MK; Wang, Q; Dennis, J; Michailidou, K; Benitez, J et al (Springer Nature, 2016)
      Background Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer. It is often associated with invasive ductal carcinoma (IDC), and is considered to be a non-obligate precursor of IDC. It is not clear to ...
    • Genome-Wide Association Study of Polymorphisms Predisposing to Bronchiolitis 

      Pasanen Anu; Karjalainen Minna K; Bont Louis; Piippo-Savolainen Eija; Ruotsalainen Marja; Goksör Emma; Kumawat Kuldeep; Hodemaekers Hennie; Nuolivirta Kirsi; Jartti Tuomas; Wennergren Göran; Hallman Mikko; Rämet Mika; Korppi Matti (Springer Nature, 2017)
      Bronchiolitis is a major cause of hospitalization among infants. Severe bronchiolitis is associated with later asthma, suggesting a common genetic predisposition. Genetic background of bronchiolitis is not well characterized. ...
    • Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels 

      Kilpeläinen, TO; Carli, JF; Skowronski, AA; Sun, Q; Kriebel, J; Feitosa, MF; Hedman, ÅK; Drong, AW; Hayes, JE; Zhao, J; Pers, TH; Schick, U; Grarup, N; Kutalik, Z; Trompet, S; Mangino, M; Kristiansson, K; Beekman, M; Lyytikäinen, LP; Eriksson, J et al (Nature Publishing Group, 2016)
      Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe ...
    • Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults 

      Graff M; Scott RA; Justice AE; Young KL; Feitosa MF; Barata L; Winkler TW; Chu AY; Mahajan A; Hadley D; Xue L; Workalemahu T; Heard-Costa NL; den Hoed M; Ahluwalia TS; Qi Q; Ngwa JS; Renström F; Quaye L; Eicher JD et al. (2017)
      Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and ...
    • Girls with a History of Premature Adrenarche Have Advanced Growth and Pubertal Development at the Age of 12 Years 

      Liimatta Jani; Utriainen Pauliina; Voutilainen Raimo; Jääskeläinen Jarmo (Frontiers Media SA, 2017)
      Background: Premature adrenarche (PA) has been linked to early thelarche and menarche, but longitudinal data on growth and pubertal development after PA are insufficient. Methods: Growth and pubertal development of ...
    • Global analysis of transcription in castration-resistant prostate cancer cells uncovers active enhancers and direct androgen receptor targets 

      Toropainen Sari; Niskanen Einari A; Malinen Marjo; Sutinen Päivi; Kaikkonen Minna U; Palvimo Jorma J (Nature Publishing Group, 2016)
      Androgen receptor (AR) is a male sex steroid-activated transcription factor (TF) that plays a critical role in prostate cancers, including castration-resistant prostate cancers (CRPC) that typically express amplified levels ...
    • Global SUMOylation on active chromatin is an acute heat stress response restricting transcription 

      Niskanen, Einari A.; Malinen, Marjo; Sutinen, Päivi; Toropainen, Sari; Paakinaho, Ville; Vihervaara, Anniina; Joutsen, Jenny; Kaikkonen, Minna U.; Sistonen, Lea; Palvimo, Jorma J. (BioMed Central, 2015-07-28)
      Background Cells have developed many ways to cope with external stress. One distinctive feature in acute proteotoxic stresses, such as heat shock (HS), is rapid post-translational modification of proteins by SUMOs (small ...
    • Health behavior tracking via mobile games : a case study among school-aged children 

      Sormunen Marjorita; Miettinen Hanna (Cogent OA, 2017)
      Mobile devices are increasingly being used, in various ways, to collect data and are also increasingly related to individuals’ health behaviors. Because of the paucity of available data about the process of mobile data ...
    • Health information systems' usability-related use errors in patient safety incidents 

      Hautamäki E; Kinnunen U-M; Palojoki S (Finnish Social and Health Informatics Association, 2017)
      Health information systems contain usability issues that cause use errors, which may pose a risk to patient safety. The aim of this study was to identify what kind of usability issues in information systems cause use errors ...
    • Healthy ageing through internet counselling in the elderly: the HATICE randomised controlled trial for the prevention of cardiovascular disease and cognitive impairment 

      Richard, E; Jongstra, S; Soininen, H; Brayne, C; Moll van Charante, EP; Meiller, Y; van der Groep, B; Beishuizen, CR; Mangialasche, F; Barbera, M; Ngandu, T; Coley, N; Guillemont, J; Savy, S; Dijkgraaf, MG; Peters, RJ; van Gool, WA; Kivipelto, M; Andrieu, S (BMJ, 2016)
      Introduction Cardiovascular disease and dementia share a number of risk factors including hypertension, hypercholesterolaemia, smoking, obesity, diabetes and physical inactivity. The rise of eHealth has led to increasing ...
    • High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation 

      Sokka, Miiko; Rilla, Kirsi; Miinalainen, Ilkka; Pospiech, Helmut; Syväoja, Juhani E. (Oxford University Press (OUP), 2015-05-26)
      Nucleoli are not only organelles that produce ribosomal subunits. They are also overarching sensors of different stress conditions and they control specific nucleolar stress pathways leading to stabilization of p53. During ...
    • High Plasma Lipid Levels Reduce Efficacy of Adenovirus-Mediated Gene Therapy 

      Kivelä AM; Huusko J; Gurzeler E; Laine A; Dijkstra MH; Dragneva G; Andersen CB; Moestrup SK; Ylä-Herttuala S (2017)
      Adenoviruses are very efficient vectors for delivering therapeutic genes in preclinical and clinical trials. However, randomized controlled human trials have often been lacking clear clinically relevant results. We ...
    • High-throughput automated scoring of Ki67 in breast cancer tissue microarrays from the Breast Cancer Association Consortium 

      Abubakar, M; Howat, WJ; Daley, F; Zabaglo, L; McDuffus, LA; Blows, F; Coulson, P; Raza, Ali H; Benitez, J; Milne, R; Brenner, H; Stegmaier, C; Mannermaa, A; Chang-Claude, J; Rudolph, A; Sinn, P; Couch, FJ; Tollenaar, RA; Devilee, P; Figueroa, J et al (The Pathological Society of Great Britain and Ireland and John Wiley & Sons Ltd, 2016)
      Automated methods are needed to facilitate high-throughput and reproducible scoring of Ki67 and other markers in breast cancer tissue microarrays (TMAs) in large-scale studies. To address this need, we developed an automated ...
    • Hospital-treated mental and behavioral disorders and risk of Alzheimer's disease: A nationwide nested case-control study 

      Tapiainen V; Hartikainen S; Taipale H; Tiihonen J; Tolppanen A-M (Elsevier BV, 2017)
      Background Studies investigating psychiatric disorders as Alzheimer's disease (AD) risk factors have yielded heterogeneous findings. Differences in time windows between the exposure and outcome could be one explanation. ...
    • Hyaluronan synthase 1 : a mysterious enzyme with unexpected functions 

      Siiskonen, Hanna; Oikari, Sanna; Pasonen-Seppänen, Sanna; Rilla, Kirsi (Frontiers Media SA, 2015-02-05)
      Hyaluronan synthase 1 (HAS1) is one of three isoenzymes responsible for cellular hyaluronan synthesis. Interest in HAS1 has been limited because its role in hyaluronan production seems to be insignificant compared to the ...
    • Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene 

      Knowles, Joshua W.; Xie, Weijia; Zhang, Zhongyang; Chennemsetty, Indumathi; Assimes, Themistocles L.; Paananen, Jussi; Hansson, Ola; Pankow, James; Goodarzi, Mark O.; Carcamo-Orive, Ivan; Morris, Andrew P.; Chen, Yii-Der I.; Mäkinen, Ville-Petteri; Ganna, Andrea; Mahajan, Anubha; Guo, Xiuqing; Abbasi, Fahim; Greenawalt, Danielle M.; Lum, Pek; Molony, Cliona; Lind, Lars; Lindgren, Cecilia; Raffel, Leslie J.; Tsao, Philip S.; Schadt, Eric E.; Rotter, Jerome I.; Sinaiko, Alan; Reaven, Gerald; Yang, Xia; Hsiung, Chao A.; Groop, Leif; Cordell, Heather J.; Laakso, Markku; Hao, Ke; Ingelsson, Erik; Frayling, Timothy M.; Weedon, Michael N.; Walker, Mark; Quertermous, Thomas (American Society for Clinical Investigation, 2015-04-01)
      Decreased insulin sensitivity, also referred to as insulin resistance (IR), is a fundamental abnormality in patients with type 2 diabetes and a risk factor for cardiovascular disease. While IR predisposition is heritable, ...
    • Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus 

      Zeng, C; Guo, X; Long, J; Kuchenbaecker, KB; Droit, A; Michailidou, K; Ghoussaini, M; Kar, S; Freeman, A; Hopper, JL; Milne, RL; Bolla, MK; Wang, Q; Dennis, J; Agata, S; Ahmen, S; Aittomäki, K; Andrulis, IL; Anton-Culver, H; Antonenkova, NN et al (BioMed Central Ltd, 2016)
      Background Multiple recent genome-wide association studies (GWAS) have identified a single nucleotide polymorphism (SNP), rs10771399, at 12p11 that is associated with breast cancer risk. Method We performed a fine-scale ...