Now showing items 280-299 of 693

    • Gadoterate meglumine decreases ADC values of breast lesions depending on the b value combination 

      Arponen, O; Sudah, M; Sutela, A; Taina, M; Masarwah, A; Liimatainen, T; Vanninen, R (Springer Nature, 2018)
      To retrospectively evaluated the influence of administration of the gadolinium based intravenous contrast agent (G-CA) on apparent diffusion coefficient (ADC) values in ADC maps generated using multiple b value combinations. ...
    • Gene Expression Mapping of Histone Deacetylases and Co-factors, and Correlation with Survival Time and 1H-HRMAS Metabolomic Profile in Human Gliomas subtitle: 

      Dali-Youcef, Nassim; Froelich, Sébastien; Moussallieh, François-Marie; Chibbaro, Salvatore; Noël, Georges; Namer, Izzie J.; Heikkinen, Sami; Auwerx, Johan (Nature Publishing Group, 2015-03-20)
      Primary brain tumors are presently classified based on imaging and histopathological techniques, which remains unsatisfaying. We profiled here by quantitative real time PCR (qRT-PCR) the transcripts of eighteen histone ...
    • Gene-environment interactions involving functional variants: Results from the Breast Cancer Association Consortium 

      Barrdahl M; Rudolph A; Hopper JL; Southey MC; Broeks A; Fasching PA; Beckmann MW; Gago-Dominguez M; Castelao JE; Guénel P; Truong T; Bojesen SE; Gapstur SM; Gaudet MM; Brenner H; Arndt V; Brauch H; Hamann U; Mannermaa A; Lambrechts D et al (Wiley-Blackwell, 2017)
      Investigating the most likely causal variants identified by fine-mapping analyses may improve the power to detect gene–environment interactions. We assessed the interplay between 70 single nucleotide polymorphisms identified ...
    • Generation of a human induced pluripotent stem cell line from a patient with a rare A673T variant in amyloid precursor protein gene that reduces the risk for Alzheimer's disease 

      Lehtonen, Š; Höytyläinen, I; Voutilainen, J; Sonninen, T-M; Kuusisto, J; Laakso, M; Hämäläinen, RH; Oksanen, M; Koistinaho, J (Elsevier BV, 2018)
      An amyloid precursor protein (APP) A673T mutation was found to be protective against Alzheimer's disease (AD) and cognitive decline in the Icelandic population and to associate with decreased levels of plasma β-amyloid in ...
    • Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept 

      Franke, B; Stein, JL; Ripke, S; Anttila, V; Hibar, DP; van Hulzen, KJ; Arias-Vasquez, A; Smoller, JW; Nichols, TE; Neale, MC; McIntosh, AM; Lee, P; McMahon, FJ; Meyer-Lindenberg, A; Mattheisen, M; Andreassen, OA; Gruber, O; Sachdev, PS; Roiz-Santiañez, R; Saykin, AJ et al (Nature Publishing Group, 2016)
      Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are ...
    • Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children 

      Schnurr TM; Viitasalo A; Eloranta AM; Damsgaard CT; Mahendran Y; Have CT; Väistö J; Hjorth MF; Christensen LB; Brage S; Atalay M; Lyytikäinen LP; Lindi V; Lakka T; Michaelsen KF; Kilpeläinen TO; Hansen T (Springer Nature, 2017)
      Increased sedentariness has been linked to the growing prevalence of obesity in children, but some longitudinal studies suggest that sedentariness may be a consequence rather than a cause of increased adiposity. We used ...
    • Genetic predisposition to ductal carcinoma in situ of the breast 

      Petridis, C; Brook, MN; Shah, V; Kohut, K; Gorman, P; Caneppele, M; Levi, D; Papouli, E; Orr, N; Cox, A; Cross, SS; Dos-Santos-Silva, I; Peto, J; Swerdlow, A; Schoemaker, MJ; Bolla, MK; Wang, Q; Dennis, J; Michailidou, K; Benitez, J et al (Springer Nature, 2016)
      Background Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer. It is often associated with invasive ductal carcinoma (IDC), and is considered to be a non-obligate precursor of IDC. It is not clear to ...
    • Genetic risk factors in Finnish patients with Parkinson's disease 

      Ylönen Susanna; Siitonen Ari; Nalls Michael A; Ylikotila Pauli; Autere Jaana; Eerola-Rautio Johanna; Gibbs Raphael; Hiltunen Mikko; Tienari Pentti J; Soininen Hilkka; Singleton Andrew B; Majamaa Kari (Elsevier BV, 2017)
      Introduction Variation contributing to the risk of Parkinson's disease (PD) has been identified in several genes and at several loci including GBA, SMPD1, LRRK2, POLG1, CHCHD10 and MAPT, but the frequencies of risk variants ...
    • Genetically elevated gamma-glutamyltransferase and Alzheimer's disease 

      Kunutsor, Setor K; Laukkanen, Jari A; Burgess, Stephen (Elsevier BV, 2018)
      Observational epidemiological evidence supports a linear and independent association between serum gamma-glutamyltransferase (GGT) concentrations and the risk of Alzheimer's disease (AD). However, the causality of this ...
    • Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent 

      Guo Y; Warren Andersen S; Shu XO; Michailidou K; Bolla MK; Wang Q; Garcia-Closas M; Milne RL; Schmidt MK; Chang-Claude J; Dunning A; Bojesen SE; Ahsan H; Aittomäki K; Andrulis IL; Anton-Culver H; Arndt V; Beckmann MW; Beeghly-Fadiel A; Benitez J et al. (incl. Kosma Veli-Matti; Mannermaa Arto) (Public Library of Science (PLoS), 2016)
      Background Observational epidemiological studies have shown that high body mass index (BMI) is associated with a reduced risk of breast cancer in premenopausal women but an increased risk in postmenopausal women. It is ...
    • Genetics instability of wtAAV2 genome and AAV promoter activities in the Baculovirus/Sf9 cells system 

      Savy, A; Kaikkonen, MU; Léger, A; Dickx, Y; Galibert, L; Merten, OW (Public Library of Science (PLoS), 2018)
      The human Adeno-Associated Virus serotype 2 (wtAAV2) is a common non-pathological virus and its recombinant form (rAAV) is widely used as gene therapy vector. Although rAAVs are routinely produced in the Baculovirus/Sf9 ...
    • Genome-wide association study in Finnish twins highlights the connection between nicotine addiction and neurotrophin signaling pathway 

      Hällfors J; Palviainen T; Surakka I; Gupta R; Buchwald J; Raevuori A; Ripatti S; Korhonen T; Jousilahti P; Madden PAF; Kaprio J; Loukola A (Wiley-Blackwell, 2018)
      The heritability of nicotine dependence based on family studies is substantial. Nevertheless, knowledge of the underlying genetic architecture remains meager. Our aim was to identify novel genetic variants responsible for ...
    • A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling 

      Li D; Chang X; Connolly JJ; Tian L; Liu Y; Bhoj EJ; Robinson N; Abrams D; Li YR; Bradfield JP; Kim CE; Li J; Wang F; Snyder J; Lemma M; Hou C; Wei Z; Guo Y; Qiu H; Mentch FD; Thomas KA; Chiavacci RM; Cone R; Li B; Sleiman PA; Hakonarson H; Karhunen L et al (Springer Nature, 2017)
      We conducted a genome-wide association study (GWAS) of anorexia nervosa (AN) using a stringently defined phenotype. Analysis of phenotypic variability led to the identification of a specific genetic risk factor that ...
    • Genome-Wide Association Study of Polymorphisms Predisposing to Bronchiolitis 

      Pasanen Anu; Karjalainen Minna K; Bont Louis; Piippo-Savolainen Eija; Ruotsalainen Marja; Goksör Emma; Kumawat Kuldeep; Hodemaekers Hennie; Nuolivirta Kirsi; Jartti Tuomas; Wennergren Göran; Hallman Mikko; Rämet Mika; Korppi Matti (Springer Nature, 2017)
      Bronchiolitis is a major cause of hospitalization among infants. Severe bronchiolitis is associated with later asthma, suggesting a common genetic predisposition. Genetic background of bronchiolitis is not well characterized. ...
    • Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels 

      Kilpeläinen, TO; Carli, JF; Skowronski, AA; Sun, Q; Kriebel, J; Feitosa, MF; Hedman, ÅK; Drong, AW; Hayes, JE; Zhao, J; Pers, TH; Schick, U; Grarup, N; Kutalik, Z; Trompet, S; Mangino, M; Kristiansson, K; Beekman, M; Lyytikäinen, LP; Eriksson, J et al (Nature Publishing Group, 2016)
      Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe ...
    • Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults 

      Graff M; Scott RA; Justice AE; Young KL; Feitosa MF; Barata L; Winkler TW; Chu AY; Mahajan A; Hadley D; Xue L; Workalemahu T; Heard-Costa NL; den Hoed M; Ahluwalia TS; Qi Q; Ngwa JS; Renström F; Quaye L; Eicher JD et al. (2017)
      Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and ...
    • Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk 

      Braenne Ingrid; Zeng Lingyao; Willenborg Christina; Tragante Vinicius; Kessler Thorsten; Willer Cristen J; Laakso Markku; Wallentin Lars; Franks Paul W; Salomaa Veikko; Dehghan Abbas; Meitinger Thomas; Samani Nilesh J; Asselbergs Folkert W; Erdmann Jeanette; Schunkert Heribert; CARDIoGRAM Consortium; CARDIoGRAMplusC4D Consortium (Public Library of Science (PLoS), 2017)
      Glatiramer acetate is used therapeutically in multiple sclerosis but also known for adverse effects including elevated coronary artery disease (CAD) risk. The mechanisms underlying the cardiovascular side effects of the ...
    • A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors 

      Brænne I; Willenborg C; Tragante V; Kessler T; Zeng L; Reiz B; Kleinecke M; von Ameln S; Willer CJ; Laakso M; Wild PS; Zeller T; Wallentin L; Franks PW; Salomaa V; Dehghan A; Meitinger T; Samani NJ; Asselbergs FW; Erdmann J; Schunkert H (Springer Nature, 2017)
      Cyclooxygenase-2 inhibitors (coxibs) are characterized by multiple molecular off-target effects and increased coronary artery disease (CAD) risk. Here, we systematically explored common variants of genes representing ...
    • Girls with a History of Premature Adrenarche Have Advanced Growth and Pubertal Development at the Age of 12 Years 

      Liimatta Jani; Utriainen Pauliina; Voutilainen Raimo; Jääskeläinen Jarmo (Frontiers Media SA, 2017)
      Background: Premature adrenarche (PA) has been linked to early thelarche and menarche, but longitudinal data on growth and pubertal development after PA are insufficient. Methods: Growth and pubertal development of ...
    • Global analysis of transcription in castration-resistant prostate cancer cells uncovers active enhancers and direct androgen receptor targets 

      Toropainen Sari; Niskanen Einari A; Malinen Marjo; Sutinen Päivi; Kaikkonen Minna U; Palvimo Jorma J (Nature Publishing Group, 2016)
      Androgen receptor (AR) is a male sex steroid-activated transcription factor (TF) that plays a critical role in prostate cancers, including castration-resistant prostate cancers (CRPC) that typically express amplified levels ...