Now showing items 537-556 of 1362

    • Gadoterate meglumine decreases ADC values of breast lesions depending on the b value combination 

      Arponen, O; Sudah, M; Sutela, A; Taina, M; Masarwah, A; Liimatainen, T; Vanninen, R (Springer Nature, 2018)
      To retrospectively evaluated the influence of administration of the gadolinium based intravenous contrast agent (G-CA) on apparent diffusion coefficient (ADC) values in ADC maps generated using multiple b value combinations. ...
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    • Galactography is not an obsolete investigation in the evaluation of pathological nipple discharge 

      Istomin, A; Masarwah, A; Pitkänen, M; Joukainen, S; Sutela, A; Vanninen, R; Sudah, M (Public Library of Science (PLoS), 2018)
      Purpose To evaluate the malignancy rate and diagnostic performance of galactography in patients with pathological nipple discharge (PND) after negative clinical breast examination, mammography and ultrasound. Materials ...
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    • Gambling expenditure by game type among weekly gamblers in Finland 

      Salonen, Anne H; Kontto, Jukka; Perhoniemi, Riku; Alho, Hannu; Castren, Sari (Springer Nature, 2018)
      Background Excessive expenditure and financial harms are core features of problem gambling. There are various forms of gambling and their nature varies. The aim was to measure gambling expenditure by game type while ...
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    • Gene Expression Mapping of Histone Deacetylases and Co-factors, and Correlation with Survival Time and 1H-HRMAS Metabolomic Profile in Human Gliomas subtitle: 

      Dali-Youcef, Nassim; Froelich, Sébastien; Moussallieh, François-Marie; Chibbaro, Salvatore; Noël, Georges; Namer, Izzie J.; Heikkinen, Sami; Auwerx, Johan (Nature Publishing Group, 2015)
      Primary brain tumors are presently classified based on imaging and histopathological techniques, which remains unsatisfaying. We profiled here by quantitative real time PCR (qRT-PCR) the transcripts of eighteen histone ...

    • Gene-environment interactions involving functional variants: Results from the Breast Cancer Association Consortium 

      Barrdahl M; Rudolph A; Hopper JL; Southey MC; Broeks A; Fasching PA; Beckmann MW; Gago-Dominguez M; Castelao JE; Guénel P; Truong T; Bojesen SE; Gapstur SM; Gaudet MM; Brenner H; Arndt V; Brauch H; Hamann U; Mannermaa A; Lambrechts D et al (Wiley-Blackwell, 2017)
      Investigating the most likely causal variants identified by fine-mapping analyses may improve the power to detect gene–environment interactions. We assessed the interplay between 70 single nucleotide polymorphisms identified ...

    • Generation of a human induced pluripotent stem cell line (LL008 1.4) from a familial Alzheimer's disease patient carrying a double KM670/671NL (Swedish) mutation in APP gene 

      Oksanen, Minna; Hyötyläinen, Ida; Voutilainen, Jenni; Puttonen, Katja A; Hämäläinen, Riikka H; Graff, Caroline; Lehtonen, Šarka; Koistinaho, Jari (Elsevier BV, 2018)
      A double mutation (KM670/671NL) in amyloid precursor protein gene (APP) is causative for familial Alzheimer's disease and has been shown to increase the total Aβ burden. Here we report the generation and characterization ...
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    • Generation of a human induced pluripotent stem cell line from a patient with a rare A673T variant in amyloid precursor protein gene that reduces the risk for Alzheimer's disease 

      Lehtonen, Š; Höytyläinen, I; Voutilainen, J; Sonninen, T-M; Kuusisto, J; Laakso, M; Hämäläinen, RH; Oksanen, M; Koistinaho, J (Elsevier BV, 2018)
      An amyloid precursor protein (APP) A673T mutation was found to be protective against Alzheimer's disease (AD) and cognitive decline in the Icelandic population and to associate with decreased levels of plasma β-amyloid in ...
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    • Genes and Dietary Fatty Acids in Regulation of Fatty Acid Composition of Plasma and Erythrocyte Membrane 

      Lankinen, M; Uusitupa, M; Schwab, U (MDPI AG, 2018)
      The fatty acid compositions of plasma lipids and cell membranes of certain tissues are modified by dietary fatty acid composition. Furthermore, many other factors (age, sex, ethnicity, health status, genes, and gene × diet ...
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    • Genetic architecture of human plasma lipidome and its link to cardiovascular disease 

      Tabassum, Rubina; Ramo, Joel T; Ripatti, Pietari; Koskela, Jukka T; Kurki, Mitja; Karjalainen, Juha; Palta, Priit; Hassan, Shabbeer; Nunez-Fontarnau, Javier; Kiiskinen, Tuomo T J; Söderlund, Sanni; Matikainen, Niina; Gerl, Mathias J; Surma, Michal A; Klose, Christian; Stitziel, Nathan O; Laivuori, Hannele; Havulinna, Aki S; Service, Susan K; Salomaa, Veikko et al. (Incl Mannermaa, Arto; Heikkinen, Sami; Kosma, Veli-Matti; Soininen, Hilkka; Kälviäinen, Reetta) (Springer Science and Business Media LLC, 2019)
      Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species ...
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    • Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept 

      Franke, B; Stein, JL; Ripke, S; Anttila, V; Hibar, DP; van Hulzen, KJ; Arias-Vasquez, A; Smoller, JW; Nichols, TE; Neale, MC; McIntosh, AM; Lee, P; McMahon, FJ; Meyer-Lindenberg, A; Mattheisen, M; Andreassen, OA; Gruber, O; Sachdev, PS; Roiz-Santiañez, R; Saykin, AJ et al (Nature Publishing Group, 2016)
      Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are ...

    • Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children 

      Schnurr TM; Viitasalo A; Eloranta AM; Damsgaard CT; Mahendran Y; Have CT; Väistö J; Hjorth MF; Christensen LB; Brage S; Atalay M; Lyytikäinen LP; Lindi V; Lakka T; Michaelsen KF; Kilpeläinen TO; Hansen T (Springer Nature, 2017)
      Increased sedentariness has been linked to the growing prevalence of obesity in children, but some longitudinal studies suggest that sedentariness may be a consequence rather than a cause of increased adiposity. We used ...

    • Genetic predisposition to ductal carcinoma in situ of the breast 

      Petridis, C; Brook, MN; Shah, V; Kohut, K; Gorman, P; Caneppele, M; Levi, D; Papouli, E; Orr, N; Cox, A; Cross, SS; Dos-Santos-Silva, I; Peto, J; Swerdlow, A; Schoemaker, MJ; Bolla, MK; Wang, Q; Dennis, J; Michailidou, K; Benitez, J et al (Springer Nature, 2016)
      Background Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer. It is often associated with invasive ductal carcinoma (IDC), and is considered to be a non-obligate precursor of IDC. It is not clear to ...

    • Genetic predisposition to higher body fat yet lower cardiometabolic risk in children and adolescents 

      Viitasalo, A; Schnurr, TM; Pitkänen, N; Hollensted, M; Nielsen, TRH; Pahkala, K; Lintu, N; Lind, MV; Atalay, M; Frithioff-Bøjsøe, C; Fonvig, CE; Grarup, N; Kähönen, M; Larnkjaer, A; Pedersen, O; Holm, JC; Michaelsen, KF; Lakka, TA; Lehtimäki, T; Raitakari, O; et al. (Springer Science and Business Media LLC, 2019)
      Background Most obese children show cardiometabolic impairments, such as insulin resistance, dyslipidemia, and hypertension. Yet some obese children retain a normal cardiometabolic profile. The mechanisms underlying this ...
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    • Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells 

      Aherrahrou, Rédouane; Guo, Liang; Nagraj, Vijay Peter; Aguhob, Aaron Andrew; Hinkle, Jameson; Chen, Lisa; Soh, Joon Yuhl; Lue, Dillon; Alencar, Gabriel F; Boltjes, Arjan; van der Laan, Sander W; Farber, Emily; Fuller, Daniela; Anane-Wae, Rita; Akingbesote, Ngozi D; Manichaikul, Ani W; Ma, Lijiang; Kaikkonen, Minna U; Björkegren, Johan LM; Önengüt-Gümüscu, Suna; et al. (Ovid Technologies (Wolters Kluwer Health), 2020)
      Rationale: Coronary artery disease (CAD) is a major cause of morbidity and mortality worldwide. Recent genome-wide association studies revealed 163 loci associated with CAD. However, the precise molecular mechanisms by ...
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    • Genetic risk factors in Finnish patients with Parkinson's disease 

      Ylönen Susanna; Siitonen Ari; Nalls Michael A; Ylikotila Pauli; Autere Jaana; Eerola-Rautio Johanna; Gibbs Raphael; Hiltunen Mikko; Tienari Pentti J; Soininen Hilkka; Singleton Andrew B; Majamaa Kari (Elsevier BV, 2017)
      Introduction Variation contributing to the risk of Parkinson's disease (PD) has been identified in several genes and at several loci including GBA, SMPD1, LRRK2, POLG1, CHCHD10 and MAPT, but the frequencies of risk variants ...

    • Genetic variants in the MTHFR are not associated with fatty liver disease. 

      De Vincentis, Antonio; Mancina, Rosellina Margherita; Pihlamajäki, Jussi; Männistö, Ville; Petta, Salvatore; Dongiovanni, Paola; Fracanzani, Anna; Valenti, Luca; Tavaglione, Federica; Romeo, Stefano; Vespasiani-Gentilucci, Umberto (Wiley, 2020)
      The common missense sequence variants of methylenetetrahydrofolate reductase (MTHFR), rs1801131 (c.A1298C) and rs1801133 (c.C677T), favour the development of hyperhomocysteinemia and diminished DNA methylation. Previous ...
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    • Genetically elevated gamma-glutamyltransferase and Alzheimer's disease 

      Kunutsor, Setor K; Laukkanen, Jari A; Burgess, Stephen (Elsevier BV, 2018)
      Observational epidemiological evidence supports a linear and independent association between serum gamma-glutamyltransferase (GGT) concentrations and the risk of Alzheimer's disease (AD). However, the causality of this ...
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    • Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease 

      Peloso, GM; van der Lee, SJ; International Genomics of Alzheimer's Project (IGAP); Destefano, AL; Seshardi, S; et al. (incl. Hiltunen, Mikko; Haapasalo, Annakaisa; Helisalmi, Seppo; Koivisto, Anne) (Elsevier BV, 2018)
      Introduction There is conflicting evidence whether high-density lipoprotein cholesterol (HDL-C) is a risk factor for Alzheimer's disease (AD) and dementia. Genetic variation in the cholesteryl ester transfer protein (CETP) ...
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    • Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent 

      Guo Y; Warren Andersen S; Shu XO; Michailidou K; Bolla MK; Wang Q; Garcia-Closas M; Milne RL; Schmidt MK; Chang-Claude J; Dunning A; Bojesen SE; Ahsan H; Aittomäki K; Andrulis IL; Anton-Culver H; Arndt V; Beckmann MW; Beeghly-Fadiel A; Benitez J et al. (incl. Kosma Veli-Matti; Mannermaa Arto) (Public Library of Science (PLoS), 2016)
      Background Observational epidemiological studies have shown that high body mass index (BMI) is associated with a reduced risk of breast cancer in premenopausal women but an increased risk in postmenopausal women. It is ...

    • Genetics instability of wtAAV2 genome and AAV promoter activities in the Baculovirus/Sf9 cells system 

      Savy, A; Kaikkonen, MU; Léger, A; Dickx, Y; Galibert, L; Merten, OW (Public Library of Science (PLoS), 2018)
      The human Adeno-Associated Virus serotype 2 (wtAAV2) is a common non-pathological virus and its recombinant form (rAAV) is widely used as gene therapy vector. Although rAAVs are routinely produced in the Baculovirus/Sf9 ...
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