Now showing items 183-202 of 454

    • Gene Expression Mapping of Histone Deacetylases and Co-factors, and Correlation with Survival Time and 1H-HRMAS Metabolomic Profile in Human Gliomas subtitle: 

      Dali-Youcef, Nassim; Froelich, Sébastien; Moussallieh, François-Marie; Chibbaro, Salvatore; Noël, Georges; Namer, Izzie J.; Heikkinen, Sami; Auwerx, Johan (Nature Publishing Group, 2015-03-20)
      Primary brain tumors are presently classified based on imaging and histopathological techniques, which remains unsatisfaying. We profiled here by quantitative real time PCR (qRT-PCR) the transcripts of eighteen histone ...
    • Gene-environment interactions involving functional variants: Results from the Breast Cancer Association Consortium 

      Barrdahl M; Rudolph A; Hopper JL; Southey MC; Broeks A; Fasching PA; Beckmann MW; Gago-Dominguez M; Castelao JE; Guénel P; Truong T; Bojesen SE; Gapstur SM; Gaudet MM; Brenner H; Arndt V; Brauch H; Hamann U; Mannermaa A; Lambrechts D et al (Wiley-Blackwell, 2017)
      Investigating the most likely causal variants identified by fine-mapping analyses may improve the power to detect gene–environment interactions. We assessed the interplay between 70 single nucleotide polymorphisms identified ...
    • Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept 

      Franke, B; Stein, JL; Ripke, S; Anttila, V; Hibar, DP; van Hulzen, KJ; Arias-Vasquez, A; Smoller, JW; Nichols, TE; Neale, MC; McIntosh, AM; Lee, P; McMahon, FJ; Meyer-Lindenberg, A; Mattheisen, M; Andreassen, OA; Gruber, O; Sachdev, PS; Roiz-Santiañez, R; Saykin, AJ et al (Nature Publishing Group, 2016)
      Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are ...
    • Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children 

      Schnurr TM; Viitasalo A; Eloranta AM; Damsgaard CT; Mahendran Y; Have CT; Väistö J; Hjorth MF; Christensen LB; Brage S; Atalay M; Lyytikäinen LP; Lindi V; Lakka T; Michaelsen KF; Kilpeläinen TO; Hansen T (Springer Nature, 2017)
      Increased sedentariness has been linked to the growing prevalence of obesity in children, but some longitudinal studies suggest that sedentariness may be a consequence rather than a cause of increased adiposity. We used ...
    • Genetic predisposition to ductal carcinoma in situ of the breast 

      Petridis, C; Brook, MN; Shah, V; Kohut, K; Gorman, P; Caneppele, M; Levi, D; Papouli, E; Orr, N; Cox, A; Cross, SS; Dos-Santos-Silva, I; Peto, J; Swerdlow, A; Schoemaker, MJ; Bolla, MK; Wang, Q; Dennis, J; Michailidou, K; Benitez, J et al (Springer Nature, 2016)
      Background Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer. It is often associated with invasive ductal carcinoma (IDC), and is considered to be a non-obligate precursor of IDC. It is not clear to ...
    • Genetic risk factors in Finnish patients with Parkinson's disease 

      Ylönen Susanna; Siitonen Ari; Nalls Michael A; Ylikotila Pauli; Autere Jaana; Eerola-Rautio Johanna; Gibbs Raphael; Hiltunen Mikko; Tienari Pentti J; Soininen Hilkka; Singleton Andrew B; Majamaa Kari (Elsevier BV, 2017)
      Introduction Variation contributing to the risk of Parkinson's disease (PD) has been identified in several genes and at several loci including GBA, SMPD1, LRRK2, POLG1, CHCHD10 and MAPT, but the frequencies of risk variants ...
    • Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent 

      Guo Y; Warren Andersen S; Shu XO; Michailidou K; Bolla MK; Wang Q; Garcia-Closas M; Milne RL; Schmidt MK; Chang-Claude J; Dunning A; Bojesen SE; Ahsan H; Aittomäki K; Andrulis IL; Anton-Culver H; Arndt V; Beckmann MW; Beeghly-Fadiel A; Benitez J et al. (incl. Kosma Veli-Matti; Mannermaa Arto) (Public Library of Science (PLoS), 2016)
      Background Observational epidemiological studies have shown that high body mass index (BMI) is associated with a reduced risk of breast cancer in premenopausal women but an increased risk in postmenopausal women. It is ...
    • A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling 

      Li D; Chang X; Connolly JJ; Tian L; Liu Y; Bhoj EJ; Robinson N; Abrams D; Li YR; Bradfield JP; Kim CE; Li J; Wang F; Snyder J; Lemma M; Hou C; Wei Z; Guo Y; Qiu H; Mentch FD; Thomas KA; Chiavacci RM; Cone R; Li B; Sleiman PA; Hakonarson H; Karhunen L et al (Springer Nature, 2017)
      We conducted a genome-wide association study (GWAS) of anorexia nervosa (AN) using a stringently defined phenotype. Analysis of phenotypic variability led to the identification of a specific genetic risk factor that ...
    • Genome-Wide Association Study of Polymorphisms Predisposing to Bronchiolitis 

      Pasanen Anu; Karjalainen Minna K; Bont Louis; Piippo-Savolainen Eija; Ruotsalainen Marja; Goksör Emma; Kumawat Kuldeep; Hodemaekers Hennie; Nuolivirta Kirsi; Jartti Tuomas; Wennergren Göran; Hallman Mikko; Rämet Mika; Korppi Matti (Springer Nature, 2017)
      Bronchiolitis is a major cause of hospitalization among infants. Severe bronchiolitis is associated with later asthma, suggesting a common genetic predisposition. Genetic background of bronchiolitis is not well characterized. ...
    • Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels 

      Kilpeläinen, TO; Carli, JF; Skowronski, AA; Sun, Q; Kriebel, J; Feitosa, MF; Hedman, ÅK; Drong, AW; Hayes, JE; Zhao, J; Pers, TH; Schick, U; Grarup, N; Kutalik, Z; Trompet, S; Mangino, M; Kristiansson, K; Beekman, M; Lyytikäinen, LP; Eriksson, J et al (Nature Publishing Group, 2016)
      Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe ...
    • Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults 

      Graff M; Scott RA; Justice AE; Young KL; Feitosa MF; Barata L; Winkler TW; Chu AY; Mahajan A; Hadley D; Xue L; Workalemahu T; Heard-Costa NL; den Hoed M; Ahluwalia TS; Qi Q; Ngwa JS; Renström F; Quaye L; Eicher JD et al. (2017)
      Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and ...
    • Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk 

      Braenne Ingrid; Zeng Lingyao; Willenborg Christina; Tragante Vinicius; Kessler Thorsten; Willer Cristen J; Laakso Markku; Wallentin Lars; Franks Paul W; Salomaa Veikko; Dehghan Abbas; Meitinger Thomas; Samani Nilesh J; Asselbergs Folkert W; Erdmann Jeanette; Schunkert Heribert; CARDIoGRAM Consortium; CARDIoGRAMplusC4D Consortium (Public Library of Science (PLoS), 2017)
      Glatiramer acetate is used therapeutically in multiple sclerosis but also known for adverse effects including elevated coronary artery disease (CAD) risk. The mechanisms underlying the cardiovascular side effects of the ...
    • A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors 

      Brænne I; Willenborg C; Tragante V; Kessler T; Zeng L; Reiz B; Kleinecke M; von Ameln S; Willer CJ; Laakso M; Wild PS; Zeller T; Wallentin L; Franks PW; Salomaa V; Dehghan A; Meitinger T; Samani NJ; Asselbergs FW; Erdmann J; Schunkert H (Springer Nature, 2017)
      Cyclooxygenase-2 inhibitors (coxibs) are characterized by multiple molecular off-target effects and increased coronary artery disease (CAD) risk. Here, we systematically explored common variants of genes representing ...
    • Girls with a History of Premature Adrenarche Have Advanced Growth and Pubertal Development at the Age of 12 Years 

      Liimatta Jani; Utriainen Pauliina; Voutilainen Raimo; Jääskeläinen Jarmo (Frontiers Media SA, 2017)
      Background: Premature adrenarche (PA) has been linked to early thelarche and menarche, but longitudinal data on growth and pubertal development after PA are insufficient. Methods: Growth and pubertal development of ...
    • Global analysis of transcription in castration-resistant prostate cancer cells uncovers active enhancers and direct androgen receptor targets 

      Toropainen Sari; Niskanen Einari A; Malinen Marjo; Sutinen Päivi; Kaikkonen Minna U; Palvimo Jorma J (Nature Publishing Group, 2016)
      Androgen receptor (AR) is a male sex steroid-activated transcription factor (TF) that plays a critical role in prostate cancers, including castration-resistant prostate cancers (CRPC) that typically express amplified levels ...
    • Global SUMOylation on active chromatin is an acute heat stress response restricting transcription 

      Niskanen, Einari A.; Malinen, Marjo; Sutinen, Päivi; Toropainen, Sari; Paakinaho, Ville; Vihervaara, Anniina; Joutsen, Jenny; Kaikkonen, Minna U.; Sistonen, Lea; Palvimo, Jorma J. (BioMed Central, 2015-07-28)
      Background Cells have developed many ways to cope with external stress. One distinctive feature in acute proteotoxic stresses, such as heat shock (HS), is rapid post-translational modification of proteins by SUMOs (small ...
    • Health behavior tracking via mobile games : a case study among school-aged children 

      Sormunen Marjorita; Miettinen Hanna (Cogent OA, 2017)
      Mobile devices are increasingly being used, in various ways, to collect data and are also increasingly related to individuals’ health behaviors. Because of the paucity of available data about the process of mobile data ...
    • Health information systems' usability-related use errors in patient safety incidents 

      Hautamäki E; Kinnunen U-M; Palojoki S (Finnish Social and Health Informatics Association, 2017)
      Health information systems contain usability issues that cause use errors, which may pose a risk to patient safety. The aim of this study was to identify what kind of usability issues in information systems cause use errors ...
    • Health-related quality of life after obstetric intensive care admission: Comparison with the general population 

      Seppänen PM; Sund RT; Ala-Kokko TI; Uotila JT; Helminen MT; Suominen TM (Elsevier BV, 2017)
      Purpose To examine health-related quality of life (HRQoL) in obstetric patients after intensive care discharge, with comparison to age-appropriate reference values from the general Finnish female population. Material ...
    • Healthy ageing through internet counselling in the elderly: the HATICE randomised controlled trial for the prevention of cardiovascular disease and cognitive impairment 

      Richard, E; Jongstra, S; Soininen, H; Brayne, C; Moll van Charante, EP; Meiller, Y; van der Groep, B; Beishuizen, CR; Mangialasche, F; Barbera, M; Ngandu, T; Coley, N; Guillemont, J; Savy, S; Dijkgraaf, MG; Peters, RJ; van Gool, WA; Kivipelto, M; Andrieu, S (BMJ, 2016)
      Introduction Cardiovascular disease and dementia share a number of risk factors including hypertension, hypercholesterolaemia, smoking, obesity, diabetes and physical inactivity. The rise of eHealth has led to increasing ...