Now showing items 273-292 of 454

    • Macrophage selective photodynamic therapy by meta-tetra(hydroxyphenyl)chlorin loaded polymeric micelles : a possible treatment for cardiovascular diseases 

      Wennink JWH; Liu Y; Mäkinen PI; Setaro F; de la Escosura A; Bourajjaj M; Lappalainen JP; Holappa LP; van den Dikkenberg JB; Al Fartousi M; Trohopoulos PN; Ylä-Herttuala S; Torres T; Hennink WE; van Nostrum CF (Alankomaat, 2017)
      Selective elimination of macrophages by photodynamic therapy (PDT) is a new and promising therapeutic modality for the reduction of atherosclerotic plaques. m-Tetra(hydroxyphenyl)chlorin (mTHPC, or Temoporfin) may be ...
    • Magnetic resonance imaging (MRI)-defined cartilage degeneration and joint pain are associated with poor physical function in knee osteoarthritis - the Oulu Knee Osteoarthritis study 

      Kaukinen P; Podlipská J; Guermazi A; Niinimäki J; Lehenkari P; Roemer FW; Nieminen MT; Koski JM; Saarakkala S; Arokoski JPA (Elsevier BV, 2017)
      Objective The main aim was to investigate the associations between Magnetic Resonance Imaging (MRI)-defined structural pathologies of the knee and physical function. Design A cohort study with frequency matching on ...
    • Magnetic SiO[2]@CoFe[2]O[4] nanoparticles decorated on graphene oxide as efficient adsorbents for the removal of anionic pollutants from water 

      Santhosha Chella; Daneshvar Ehsan; Kollu Pratap; Peräniemi Sirpa; Nirmala Grace Andrews; Bhatnagar Amit (2017)
      In this study, magnetic nanocomposites viz. SiO2@CoFe2O4 nanoparticles decorated on graphene oxide were synthesized using solvothermal and sol-gel processes. The prepared nanocomposite materials were used as magnetic ...
    • Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease 

      Folkersen L; Fauman E; Sabater-Lleal M; Strawbridge RJ; Frånberg M; Sennblad B; Baldassarre D; Veglia F; Humphries SE; Rauramaa R; de Faire U; Smit AJ; Giral P; Kurl S; Mannarino E; Enroth S; Johansson Å; Enroth SB; Gustafsson S; Lind L et al; IMPROVE Study Group (Public Library of Science (PLoS), 2017)
      Recent advances in highly multiplexed immunoassays have allowed systematic large-scale measurement of hundreds of plasma proteins in large cohort studies. In combination with genotyping, such studies offer the prospect to ...
    • Maternal and fetal genetic contribution to gestational weight gain 

      Warrington NM; Richmond R; Fenstra B; Myhre R; Gaillard R; Paternoster L; Wang CA; Beaumont RN; Das S; Murcia M; Barton SJ; Espinosa A; Thiering E; Atalay M; Pitkänen N; Ntalla I; Jonsson AE; Freathy R; Karhunen V; Tiesler CMT et al. for the Early Growth Genetics (EGG) consortium (Springer Nature, 2017)
      Background: Clinical recommendations to limit gestational weight gain (GWG) imply high GWG is causally related to adverse outcomes in mother or offspring, but GWG is the sum of several inter-related complex phenotypes ...
    • Maternal use of selective serotonin reuptake inhibitors and lengthening of the umbilical cord: indirect evidence of increased foetal activity - a retrospective cohort study. 

      Kivistö, Julia; Lehto, Soili M; Halonen, Katja; Georgiadis, Leena; Heinonen, Seppo (Public Library of Science (PLoS), 2016)
      Background Antenatal depression affects up to 19% of pregnant women. Some of these women are also in need of antidepressant treatment. Nevertheless, the impact of maternal antidepressant treatment and prenatal depression ...
    • MB-SWIFT functional MRI during deep brain stimulation in rats 

      Lehto Lauri J; Idiyatullin Djaudat; Zhang Jinjin; Utecht Lynn; Adriany Gregor; Garwood Michael; Gröhn Olli; Michaeli Shalom; Mangia Silvia (Elsevier BV, 2017)
      Recently introduced 3D radial MRI pulse sequence entitled Multi-Band SWeep Imaging with Fourier Transformation (MB-SWIFT) having virtually zero acquisition delay was used to obtain functional MRI (fMRI) contrast in rat's ...
    • Medication safety and the usability of electronic prescribing as perceived by physicians: a semistructured interview among primary health care physicians in Finland 

      Kauppinen H; Ahonen R; Mäntyselkä P; Timonen J (Wiley-Blackwell, 2017)
      Rationale, aims and objectives In Finland, a fully operational and nationwide electronic prescription (ePrescription) system was implemented by law in 2012 to 2015. From 2017, all prescriptions have to be electronic. ...
    • Melanin binding study of clinical drugs with cassette dosing and rapid equilibrium dialysis inserts 

      Pelkonen L; Tengvall-Unadike U; Ruponen M; Kidron H; del Amo EM; Reinisalo M; Urtti A (Elsevier BVAlankomaat, 2017)
      Melanin pigment is a negatively charged polymer found in pigmented human tissues. In the eye, iris, ciliary body, choroid and retinal pigment epithelium (RPE) are heavily pigmented. Several drug molecules are known to bind ...
    • Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer 

      Jarvis D; Mitchell JS; Law PJ; Palin K; Tuupanen S; Gylfe A; Hänninen UA; Cajuso T; Tanskanen T; Kondelin J; Kaasinen E; Sarin A-P; Kaprio J; Eriksson JG; Rissanen H; Knekt P; Pukkala E; Jousilahti P; Salomaa V; Ripatti S; Palotie A; Järvinen H; Renkonen-Sinisalo L; Lepistö A; Böhm J; Meklin J-P; Al-Tassan NA; Palles C; Martin L; Barclay E; Farrington SM; Timofeeva MN; Meyer BF; Wakil SM; Campbell H; Smith C.G; Idziaszczyk S; Maughan TS; Kaplan R; Kerr R; Kerr D; Buchanan DD; Win AK; Hopper JL; Jenkins MA; Lindor NM; Newcomb PA (Cancer Research UK, 2016-06-23)
      Background: Observational studies have associated adiposity with an increased risk of colorectal cancer (CRC). However, such studies do not establish a causal relationship. To minimise bias from confounding we performed ...
    • Metabolic profiling of polycystic ovary syndrome reveals interactions with abdominal obesity 

      Couto Alves A; Valcarcel B; Mäkinen VP; Morin-Papunen L; Sebert S; Kangas AJ; Soininen P; Das S; De Iorio M; Coin L; Ala-Korpela M; Järvelin MR; Franks S (Springer Nature, 2017)
      Background: Polycystic ovary syndrome (PCOS) is a common reproductive disorder associated with metabolic disturbances including obesity, insulin resistance and diabetes mellitus. Here we investigate whether changes in ...
    • Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase 

      Würtz, Peter; Wang, Qin; Soininen, Pasi; Kangas, Antti J; Fatemifar, Ghazaleh; Tynkkynen, Tuulia; Tiainen, Mika; Perola, Markus; Tillin, Therese; Hughes, Alun D; Mäntyselkä, Pekka; Kähönen, Mika; Lehtimäki, Terho; Sattar, Naveed; Hingorani, Aroon D; Casas, Juan-Pablo; Salomaa, Veikko; Kivimäki, Mika; Järvelin, Marjo-Riitta; Davey Smith George et al (Elsevier Inc.; American College of Cardiology, 2016)
      Background Statins are first-line therapy for cardiovascular disease prevention, but their systemic effects across lipoprotein subclasses, fatty acids, and circulating metabolites remain incompletely characterized. O ...
    • metaCCA: summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis 

      Cichonska Anna; Rousu Juho; Marttinen Pekka; Kangas Antti J; Soininen Pasi; Lehtimäki Terho; Raitakari Olli T; Järvelin Marjo-Riitta; Salomaa Veikko; Ala-Korpela Mika; Ripatti Samuli; Pirinen Matti (Oxford University Press (OUP), 2016)
      Motivation A dominant approach to genetic association studies is to perform univariate tests between genotype-phenotype pairs. However, analyzing related traits together increases statistical power, and certain complex ...
    • Metastatic state of parent cells influences the uptake and functionality of prostate cancer cell-derived extracellular vesicles 

      Lazaro-Ibanez Elisa; Neuvonen Maarit; Takatalo Maarit; Arasu Uma Thanigai; Capasso Cristian; Cerullo Vincenzo; Rhim Johng S; Rilla Kirsi; Yliperttula Marjo; Siljander Pia R -M (Informa UK Limited, 2017)
      Extracellular vesicles (EVs), including microvesicles and exosomes, mediate intercellular signalling which has a profound role in cancer progression and in the development of metastasis. Internalisation of EVs can prompt ...
    • Metformin and Its Sulfenamide Prodrugs Inhibit Human Cholinesterase Activity 

      Markowicz-Piasecka Magdalena; Sikora Joanna; Mateusiak Lukasz; Mikiciuk-Olasik Elzbieta; Huttunen Kristiina M (Hindawi Limited, 2017)
      The results of epidemiological and pathophysiological studies suggest that type 2 diabetes mellitus (T2DM) may predispose to Alzheimer’s disease (AD). The two conditions present similar glucose levels, insulin resistance, ...
    • MicroRNA Profiling Reveals Distinct Profiles for Tissue-Derived and Cultured Endothelial Cells 

      Kuosmanen Suvi M; Kansanen Emilia; Sihvola Virve; Levonen Anna-Liisa (Springer Nature, 2017)
      Endothelial plasticity enables the cells to switch their phenotype according to the surrounding vascular microenvironment. MicroRNAs (miRNAs) are small noncoding RNAs that control endothelial plasticity. The objective of ...
    • Midwives perceptions of partner presence in childbirth pain alleviation in Nigeria 

      Emelonye AU; Vehviläinen-Julkunen K; Pitkäaho T; Aregbesola A (Elsevier BV, 2017)
      Objective partner presence in the labour room can influence childbirth pain outcomes and maternal well-being. We examined midwives' perception of the use of partner presence in the management of childbirth pain in Nigerian ...
    • miRandola 2017: a curated knowledge base of non-invasive biomarkers 

      Russo F; Di Bella S; Vannini F; Berti G; Scoyni F; Cook HV; Santos A; Nigita G; Bonnici V; Laganà A; Geraci F; Pulvirenti A1; Giugno R; De Masi F; Belling K; Jensen LJ; Brunak SR; Pellegrini M; Ferro A (Oxford University Press (OUP), 2017)
      miRandola (http://mirandola.iit.cnr.it/) is a database of extracellular non-coding RNAs (ncRNAs) that was initially published in 2012, foreseeing the relevance of ncRNAs as non-invasive biomarkers. An increasing amount of ...
    • Mitochondrial genes are altered in blood early in Alzheimer's disease 

      Lunnon K; Keohane A; Pidsley R; Newhouse S; Riddoch-Contreras J; Thubron EB; Devall M; Soininen H; Kloszewska I; Mecocci P; Tsolaki M; Vellas B; Schalkwyk L; Dobson R; Malik AN; Powell J; Lovestone S; Hodges A (Elsevier BVYhdysvallat (USA), 2017)
      Although mitochondrial dysfunction is a consistent feature of Alzheimer's disease in the brain and blood, the molecular mechanisms behind these phenomena are unknown. Here we have replicated our previous findings demonstrating ...
    • Modified serpinA1 as risk marker for Parkinson's disease dementia: analysis of baseline data 

      Halbgebauer, Steffen; Nagi, Magdalena; Klafki, Hans; Haußmann, Ute; Steinacker, Petra; Oeckl, Patrick; Kassubek, Jan; Pinkhardt, Elmar; Ludolph, Albert C; Soininen, Hilkka; Herukka, Sanna-Kaisa; Wiltfang, Jens; Otto, Markus (Springer Nature, 2016)
      Early detection of dementia in Parkinson disease is a prerequisite for preventive therapeutic approaches. Modified serpinA1 in cerebrospinal fluid (CSF) was suggested as an early biomarker for differentiation between ...