Now showing items 785-804 of 1362

    • Machine learning augmented near-infrared spectroscopy: In vivo follow-up of cartilage defects 

      Sarin, Jaakko K; Te Moller, Nikae Cr; Mohammadi, Ali; Prakash, Mithilesh; Torniainen, Jari; Brommer, Harold; Nippolainen, Ervin; Shaikh, Rubina; Mäkelä, Janne Ta; Korhonen, Rami K; René van Weeren, P; Afara, Isaac O; Töyräs, Juha (Elsevier BV, 2021)
      Objective To assess the potential of near-infrared spectroscopy (NIRS) for in vivo arthroscopic monitoring of cartilage defects. Method Sharp and blunt cartilage grooves were induced in the radiocarpal and intercarpal ...
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    • Machine learning identifies interacting genetic variants contributing to breast cancer risk: a case study in Finnish cases and controls 

      Behravan, H; Hartikainen, JM; Tengström, M; Pylkäs, K; Winqvist, R; Kosma, VM; Mannermaa, A (Springer Nature America, Inc, 2018)
      We propose an effective machine learning approach to identify group of interacting single nucleotide polymorphisms (SNPs), which contribute most to the breast cancer (BC) risk by assuming dependencies among BCAC iCOGS SNPs. ...
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    • Machine learning suggests sleep as a core factor in chronic pain 

      Miettinen, Teemu; Mäntyselkä, Pekka; Hagelberg, Nora; Mustola, Seppo; Kalso, Eija; Lötsch, Jörn (Ovid Technologies (Wolters Kluwer Health), 2021)
      Patients with chronic pain have complex pain profiles and associated problems. Subgroup analysis can help identify key problems. We used a data-based approach to define pain phenotypes and their most relevant associated ...
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    • Macrophage selective photodynamic therapy by meta-tetra(hydroxyphenyl)chlorin loaded polymeric micelles : a possible treatment for cardiovascular diseases 

      Wennink JWH; Liu Y; Mäkinen PI; Setaro F; de la Escosura A; Bourajjaj M; Lappalainen JP; Holappa LP; van den Dikkenberg JB; Al Fartousi M; Trohopoulos PN; Ylä-Herttuala S; Torres T; Hennink WE; van Nostrum CF (, 2017)
      Selective elimination of macrophages by photodynamic therapy (PDT) is a new and promising therapeutic modality for the reduction of atherosclerotic plaques. m-Tetra(hydroxyphenyl)chlorin (mTHPC, or Temoporfin) may be ...

    • Magnetic resonance imaging (MRI)-defined cartilage degeneration and joint pain are associated with poor physical function in knee osteoarthritis - the Oulu Knee Osteoarthritis study 

      Kaukinen P; Podlipská J; Guermazi A; Niinimäki J; Lehenkari P; Roemer FW; Nieminen MT; Koski JM; Saarakkala S; Arokoski JPA (Elsevier BV, 2017)
      Objective The main aim was to investigate the associations between Magnetic Resonance Imaging (MRI)-defined structural pathologies of the knee and physical function. Design A cohort study with frequency matching on ...

    • Magnetic SiO[2]@CoFe[2]O[4] nanoparticles decorated on graphene oxide as efficient adsorbents for the removal of anionic pollutants from water 

      Santhosha Chella; Daneshvar Ehsan; Kollu Pratap; Peräniemi Sirpa; Nirmala Grace Andrews; Bhatnagar Amit (2017)
      In this study, magnetic nanocomposites viz. SiO2@CoFe2O4 nanoparticles decorated on graphene oxide were synthesized using solvothermal and sol-gel processes. The prepared nanocomposite materials were used as magnetic ...

    • Magnitude and characteristics of clinical trials in the Kingdom of Saudi Arabia: A cross-sectional analysis 

      Ali Sheraz; Alghamdi Mesfer Ali; Alzhrani Jasser Ali; De Vol Edward B (Elsevier BV, 2017)
      The clinical trial is an important type of research design in the spectrum of translational research. The extent to which clinical trials are conducted is a reflection of the level of advancement that exists within a ...

    • Maintenance of good glycaemic control is challenging - A cohort study of type 2 diabetes patient in North Karelia Finland 

      Nazu, NA; Lindström, J; Rautiainen, P; Tirkkonen, H; Wikström, K; Repo, T; Laatikainen, T (Wiley, 2019)
      Aims This study assessed type 2 diabetes treatment outcomes and process indicators using a comprehensive type 2 diabetes patient cohort in North Karelia, Finland, from 2011 to 2016. Methods Data from all diagnosed ...
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    • MaNGA: a novel multi-objective multi-niche genetic algorithm for QSAR modelling 

      Serra, Angela; Önlü, Serli; Festa, Paola; Fortino, Vittorio; Greco, Dario (Oxford University Press (OUP), 2019)
      Quantitative structure–activity relationship (QSAR) modelling is currently used in multiple fields to relate structural properties of compounds to their biological activities. This technique is also used for drug design ...
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    • Manifesto for an international digital mental health network 

      Maron, Eduard; Baldwin, David S; Balõtšev, Roman; Fabbri, Chiara; Gaur, Vikas; Hidalgo-Mazzei, Diego; Hood, Sean; Juhola, Martti; Kampman, Olli; Kasper, Siegfried; Kärkkäinen, Hilkka; Látalová, Klára; Lähteenvuo, Markku; Mastellos, Nikolas; McTigue, Joseph; Metsallik, Janek; Metspalu, Andres; Nutt, David; Nykänen, Pirkko; Olisa, Nigel et al. (incl. Tiihonen, Jari) (Informa UK Limited, 2019)
      Current mental health services across the world remain expert-centric and are based on traditional workflows, mostly using impractical and ineffective electronic record systems or even paper-based documentation. The ...
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    • Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease 

      Folkersen L; Fauman E; Sabater-Lleal M; Strawbridge RJ; Frånberg M; Sennblad B; Baldassarre D; Veglia F; Humphries SE; Rauramaa R; de Faire U; Smit AJ; Giral P; Kurl S; Mannarino E; Enroth S; Johansson Å; Enroth SB; Gustafsson S; Lind L et al; IMPROVE Study Group (Public Library of Science (PLoS), 2017)
      Recent advances in highly multiplexed immunoassays have allowed systematic large-scale measurement of hundreds of plasma proteins in large cohort studies. In combination with genotyping, such studies offer the prospect to ...

    • Markers of liver injury and clinical outcomes in COVID-19 patients: A systematic review and meta-analysis 

      Kunutsor, Setor; Laukkanen, Jari (Elsevier BV, 2021)
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    • Marriage Dissatisfaction and the Risk of Sudden Cardiac Death Among Men 

      Isiozor, Nzechukwu M; Kunutsor, Setor K; Laukkanen, Tanjaniina; Kauhanen, Jussi; Laukkanen, Jari A (Elsevier BV, 2018)
      Conflicts in marriage have been associated with potential risk of cardiovascular disease; however, there is lack of prospective evidence on the association between marriage satisfaction and sudden cardiac death (SCD). We ...
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    • Mast cell chymase degrades fibrinogen and fibrin 

      Lipitsä, T; Siiskonen, H; Naukkarinen, A; Harvima, IT (Wiley, 2019)
      Background The accumulation of immunoreactants and fibrinoid necrosis of postcapillary vessel walls are common pathological features of cutaneous immune complex vasculitis. In more advanced lesions, these immunoreactants ...
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    • Mast Cells and Sensory Nerves Contribute to Neurogenic Inflammation and Pruritus in Chronic Skin Inflammation 

      Siiskonen, Hanna; Harvima, Ilkka (Frontiers Media SA, 2019)
      The intimate interaction between mast cells and sensory nerves can be illustrated by the wheal and surrounding flare in an urticarial reaction in human skin. This reaction is typically associated with an intense itch at ...
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    • Mastication-induced release of compounds from rye and wheat breads to saliva 

      Pentikäinen, Saara; Koistinen, Ville; Kolehmainen, Marjukka; Poutanen, Kaisa; Hanhineva, Kati; Aura, Anna-Marja (Elsevier BV, 2018)
      Mastication initiates digestion, disintegrating food structure and mixing it with saliva. This study aimed to provide understanding about the first step of bread digestion by exploring release of compounds from bread matrix ...
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    • Maternal and fetal genetic contribution to gestational weight gain 

      Warrington NM; Richmond R; Fenstra B; Myhre R; Gaillard R; Paternoster L; Wang CA; Beaumont RN; Das S; Murcia M; Barton SJ; Espinosa A; Thiering E; Atalay M; Pitkänen N; Ntalla I; Jonsson AE; Freathy R; Karhunen V; Tiesler CMT et al. for the Early Growth Genetics (EGG) consortium (Springer Nature, 2017)
      Background: Clinical recommendations to limit gestational weight gain (GWG) imply high GWG is causally related to adverse outcomes in mother or offspring, but GWG is the sum of several inter-related complex phenotypes ...

    • Maternal and neonatal characteristics in obstetric intensive care unit admissions 

      Seppänen, PM; Sund, RT; Uotila, JT; Helminen, MT; Suominen, TM (Elsevier BV, 2020)
      Background The objective of this study was to evaluate the course of pregnancy and delivery of obstetric patients admitted for intensive care, and determine the health status of their infants. Methods This was a ...
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    • Maternal Docosahexaenoic Acid Status during Pregnancy and Its Impact on Infant Neurodevelopment 

      Basak, Sanjay; Mallick, Rahul; Duttaroy, Asim K (MDPI AG, 2020)
      Dietary components are essential for the structural and functional development of the brain. Among these, docosahexaenoic acid, 22:6n-3 (DHA), is critically necessary for the structure and development of the growing fetal ...
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    • Maternal use of drugs and preeclampsia 

      Sahlman, H; Koponen, M; El-Nezami, H; Vahakangas, K; Keski-Nisula, L (Wiley, 2019)
      Aims The aim was to compare and describe maternal use of drugs between women with preeclampsia and controls and to estimate the possible association with preeclampsia. Methods The study cohort was collected from the ...
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