Now showing items 179-198 of 302

    • Macrophage selective photodynamic therapy by meta-tetra(hydroxyphenyl)chlorin loaded polymeric micelles : a possible treatment for cardiovascular diseases 

      Wennink JWH; Liu Y; Mäkinen PI; Setaro F; de la Escosura A; Bourajjaj M; Lappalainen JP; Holappa LP; van den Dikkenberg JB; Al Fartousi M; Trohopoulos PN; Ylä-Herttuala S; Torres T; Hennink WE; van Nostrum CF (Alankomaat, 2017)
      Selective elimination of macrophages by photodynamic therapy (PDT) is a new and promising therapeutic modality for the reduction of atherosclerotic plaques. m-Tetra(hydroxyphenyl)chlorin (mTHPC, or Temoporfin) may be ...
    • Magnetic SiO[2]@CoFe[2]O[4] nanoparticles decorated on graphene oxide as efficient adsorbents for the removal of anionic pollutants from water 

      Santhosha Chella; Daneshvar Ehsan; Kollu Pratap; Peräniemi Sirpa; Nirmala Grace Andrews; Bhatnagar Amit (2017)
      In this study, magnetic nanocomposites viz. SiO2@CoFe2O4 nanoparticles decorated on graphene oxide were synthesized using solvothermal and sol-gel processes. The prepared nanocomposite materials were used as magnetic ...
    • Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease 

      Folkersen L; Fauman E; Sabater-Lleal M; Strawbridge RJ; Frånberg M; Sennblad B; Baldassarre D; Veglia F; Humphries SE; Rauramaa R; de Faire U; Smit AJ; Giral P; Kurl S; Mannarino E; Enroth S; Johansson Å; Enroth SB; Gustafsson S; Lind L et al; IMPROVE Study Group (Public Library of Science (PLoS), 2017)
      Recent advances in highly multiplexed immunoassays have allowed systematic large-scale measurement of hundreds of plasma proteins in large cohort studies. In combination with genotyping, such studies offer the prospect to ...
    • Maternal use of selective serotonin reuptake inhibitors and lengthening of the umbilical cord: indirect evidence of increased foetal activity - a retrospective cohort study. 

      Kivistö, Julia; Lehto, Soili M; Halonen, Katja; Georgiadis, Leena; Heinonen, Seppo (Public Library of Science (PLoS), 2016)
      Background Antenatal depression affects up to 19% of pregnant women. Some of these women are also in need of antidepressant treatment. Nevertheless, the impact of maternal antidepressant treatment and prenatal depression ...
    • Medication safety and the usability of electronic prescribing as perceived by physicians: a semistructured interview among primary health care physicians in Finland 

      Kauppinen H; Ahonen R; Mäntyselkä P; Timonen J (Wiley-Blackwell, 2017)
      Rationale, aims and objectives In Finland, a fully operational and nationwide electronic prescription (ePrescription) system was implemented by law in 2012 to 2015. From 2017, all prescriptions have to be electronic. ...
    • Melanin binding study of clinical drugs with cassette dosing and rapid equilibrium dialysis inserts 

      Pelkonen L; Tengvall-Unadike U; Ruponen M; Kidron H; del Amo EM; Reinisalo M; Urtti A (Elsevier BVAlankomaat, 2017)
      Melanin pigment is a negatively charged polymer found in pigmented human tissues. In the eye, iris, ciliary body, choroid and retinal pigment epithelium (RPE) are heavily pigmented. Several drug molecules are known to bind ...
    • Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer 

      Jarvis D; Mitchell JS; Law PJ; Palin K; Tuupanen S; Gylfe A; Hänninen UA; Cajuso T; Tanskanen T; Kondelin J; Kaasinen E; Sarin A-P; Kaprio J; Eriksson JG; Rissanen H; Knekt P; Pukkala E; Jousilahti P; Salomaa V; Ripatti S; Palotie A; Järvinen H; Renkonen-Sinisalo L; Lepistö A; Böhm J; Meklin J-P; Al-Tassan NA; Palles C; Martin L; Barclay E; Farrington SM; Timofeeva MN; Meyer BF; Wakil SM; Campbell H; Smith C.G; Idziaszczyk S; Maughan TS; Kaplan R; Kerr R; Kerr D; Buchanan DD; Win AK; Hopper JL; Jenkins MA; Lindor NM; Newcomb PA (Cancer Research UK, 2016-06-23)
      Background: Observational studies have associated adiposity with an increased risk of colorectal cancer (CRC). However, such studies do not establish a causal relationship. To minimise bias from confounding we performed ...
    • Metabolic profiling of polycystic ovary syndrome reveals interactions with abdominal obesity 

      Couto Alves A; Valcarcel B; Mäkinen VP; Morin-Papunen L; Sebert S; Kangas AJ; Soininen P; Das S; De Iorio M; Coin L; Ala-Korpela M; Järvelin MR; Franks S (Springer Nature, 2017)
      Background: Polycystic ovary syndrome (PCOS) is a common reproductive disorder associated with metabolic disturbances including obesity, insulin resistance and diabetes mellitus. Here we investigate whether changes in ...
    • Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase 

      Würtz, Peter; Wang, Qin; Soininen, Pasi; Kangas, Antti J; Fatemifar, Ghazaleh; Tynkkynen, Tuulia; Tiainen, Mika; Perola, Markus; Tillin, Therese; Hughes, Alun D; Mäntyselkä, Pekka; Kähönen, Mika; Lehtimäki, Terho; Sattar, Naveed; Hingorani, Aroon D; Casas, Juan-Pablo; Salomaa, Veikko; Kivimäki, Mika; Järvelin, Marjo-Riitta; Davey Smith George et al (Elsevier Inc.; American College of Cardiology, 2016)
      Background Statins are first-line therapy for cardiovascular disease prevention, but their systemic effects across lipoprotein subclasses, fatty acids, and circulating metabolites remain incompletely characterized. O ...
    • metaCCA: summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis 

      Cichonska Anna; Rousu Juho; Marttinen Pekka; Kangas Antti J; Soininen Pasi; Lehtimäki Terho; Raitakari Olli T; Järvelin Marjo-Riitta; Salomaa Veikko; Ala-Korpela Mika; Ripatti Samuli; Pirinen Matti (Oxford University Press (OUP), 2016)
      Motivation A dominant approach to genetic association studies is to perform univariate tests between genotype-phenotype pairs. However, analyzing related traits together increases statistical power, and certain complex ...
    • Mitochondrial genes are altered in blood early in Alzheimer's disease 

      Lunnon K; Keohane A; Pidsley R; Newhouse S; Riddoch-Contreras J; Thubron EB; Devall M; Soininen H; Kloszewska I; Mecocci P; Tsolaki M; Vellas B; Schalkwyk L; Dobson R; Malik AN; Powell J; Lovestone S; Hodges A (Elsevier BVYhdysvallat (USA), 2017)
      Although mitochondrial dysfunction is a consistent feature of Alzheimer's disease in the brain and blood, the molecular mechanisms behind these phenomena are unknown. Here we have replicated our previous findings demonstrating ...
    • Modified serpinA1 as risk marker for Parkinson's disease dementia: analysis of baseline data 

      Halbgebauer, Steffen; Nagi, Magdalena; Klafki, Hans; Haußmann, Ute; Steinacker, Petra; Oeckl, Patrick; Kassubek, Jan; Pinkhardt, Elmar; Ludolph, Albert C; Soininen, Hilkka; Herukka, Sanna-Kaisa; Wiltfang, Jens; Otto, Markus (Springer Nature, 2016)
      Early detection of dementia in Parkinson disease is a prerequisite for preventive therapeutic approaches. Modified serpinA1 in cerebrospinal fluid (CSF) was suggested as an early biomarker for differentiation between ...
    • Modulation of sphingosine receptors influences circadian pattern of cardiac autonomic regulation 

      Simula Sakari; Laitinen Tomi P; Laitinen Tiina M; Hartikainen Päivi; Hartikainen Juha EK (Wiley-Blackwell, 2016)
      Fingolimod is an oral sphingosine‐1‐phospate (S1P) receptor modulator for the treatment of relapsing‐remitting multiple sclerosis (RRMS). In addition to therapeutic effects on lymphoid and neural tissue, fingolimod influences ...
    • Molecular endocrinology of vitamin D on the epigenome level 

      Carlberg Carsten (Elsevier BV, 2017)
      The molecular endocrinology of vitamin D is based on the facts that i) its metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) is the high affinity ligand of the nuclear receptor vitamin D receptor (VDR) and ii) the ...
    • Molecular targets of chloropicrin in human airway epithelial cells 

      Pesonen M; Rysä J; Storvik M; Rilla K; Pasanen M; Vähäkangas K (Elsevier BV, 2017)
      Chloropicrin is a vaporizing, irritating compound that causes complications in the respiratory system when inhaled. In this study, we examined the effects of exposure to chloropicrin for 24 h on ultrastructure and global ...
    • Month and Season of Birth as a Risk Factor for Alzheimer's Disease: A Nationwide Nested Case-control Study 

      Tolppanen, Anna-Maija; Ahonen, Riitta; Koponen, Marjaana; Lavikainen, Piia; Purhonen, Maija; Taipale, Heidi; Tanskanen, Antti; Tiihonen, Jari; Tiihonen, Miia; Hartikainen, Sirpa (Korean Society for Preventive Medicine, 2016)
      Objectives: Season of birth, an exogenous indicator of early life environment, has been related to higher risk of adverse psychiatric outcomes but the findings for Alzheimer’s disease (AD) have been inconsistent. We ...
    • Morphological features of the left atrial appendage in consecutive coronary computed tomography angiography patients with and without atrial fibrillation 

      Korhonen Miika; Parkkonen Johannes; Hedman Marja; Muuronen Antti; Onatsu Juha; Mustonen Pirjo; Vanninen Ritva; Taina Mikko (Public Library of Science (PLoS), 2017)
      The majority of intracardiac thrombi form in the left atrial appendage (LAA). Enlargement of this structure, together with certain morphological features, may indicate a predisposition to the formation of thrombi and ...
    • Mortality due to Vegetation Fire-Originated PM2.5 Exposure in Europe - Assessment for the Years 2005 and 2008 

      Kollanus Virpi; Prank Marje; Gens Alexandra; Soares Joana; Vira Julius; Kukkonen Jaakko; Sofiev Mikhail; Salonen Raimo O; Lanki Timo (National Institute of Environmental Health Sciences (NIEHS), 2017)
      Background: Vegetation fires can release substantial quantities of fine particles (PM2.5), which are harmful to health. The fire smoke may be transported over long distances and can cause adverse health effects over wide ...
    • A Multi-Cohort Study of ApoE e4 and Amyloid-ß Effects on the Hippocampus in Alzheimer's Disease 

      Khan W; Giampietro V; Banaschewski T; Barker GJ; Bokde ALW; Büchel C; Conrod P; Flor H; Frouin V; Garavan H; Gowland P; Heinz A; Ittermann B; Lemaître H; Nees F; Paus T; Pausova Z; Rietschel M; Smolka MN; Ströhle A et al. (IOS PressAlankomaat, 2017)
      The apolipoprotein E (APOE) gene has been consistently shown to modulate the risk of Alzheimer’s disease (AD). Here, using an AD and normal aging dataset primarily consisting of three AD multi-center studies (n = 1,781), ...
    • Multimodality scoring of chondral injuries in the equine fetlock joint ex vivo 

      Sarin Jaakko Kalevi; Brommer Harold; Argüelles David; Puhakka Pia Henriikka; Inkinen Satu Irene; Afara Isaac Oluwaseun; Saarakkala Simo; Töyräs Juha (2017)
      Objective We investigate the potential of a prototype multimodality arthroscope, combining ultrasound, optical coherence tomography (OCT) and arthroscopic indentation device, for assessing cartilage lesions, and compare ...