Now showing items 664-683 of 1012

    • NAFLD risk alleles in PNPLA3, TM6SF2, GCKR, and LYPLAL1 show divergent metabolic effects 

      Sliz, Eeva; Sebert, Sylvain; Würtz, Peter; Kangas, Antti J; Soininen, Pasi; Lehtimäki, Terho; Kähönen, Mika; Viikari, Jorma; Männikkö, Minna; Ala-Korpela, Mika; Raitakari, Olli T; Kettunen, Johannes (Oxford University Press (OUP), 2018)
    • Nanofibrillar cellulose-alginate hydrogel coated surgical sutures as cell-carrier systems 

      Laurén P; Somersalo P; Pitkänen I; Lou YR; Urtti A; Partanen J; Seppälä J; Madetoja M; Laaksonen T; Mäkitie A; Yliperttula M (Public Library of Science (PLoS), 2017)
      Hydrogel nanomaterials, especially those that are of non-human and non-animal origins, have great potential in biomedical and pharmaceutical sciences due to their versatility and inherent soft-tissue like properties. With ...
    • Natriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis 

      Natriuretic Peptides Studies Collaboration; Willeit P; Kaptoge S; Welsh P; Butterworth AS; Chowdhury R; Spackman SA; Pennells L; Gao P; Burgess S; Freitag DF; Sweeting M; Wood AM; Cook NR; Judd S; Trompet S; Nambi V; Olsen MH; Everett BM; Kee F et al. (Elsevier BV, 2016)
      Background Guidelines for primary prevention of cardiovascular diseases focus on prediction of coronary heart disease and stroke. We assessed whether or not measurement of N-terminal-pro-B-type natriuretic peptide (NT-proBNP) ...
    • Natural polyphenols as sirtuin 6 modulators 

      Rahnasto-Rilla, M; Tyni, J; Huovinen, M; Jarho, E; Kulikowicz, T; Ravichandran, S; Bohr, VA; Ferrucci, L; Lahtela-Kakkonen, M; Moaddel R (Springer Nature, 2018)
      Flavonoids are polyphenolic secondary metabolites synthesized by plants and fungus with various pharmacological effects. Due to their plethora of biological activities, they have been studied extensively in drug development. ...
    • Neuregulin signaling pathway in smoking behavior 

      Gupta R; Qaiser B; He L; Hiekkalinna TS; Zheutlin AB; Therman S; Ollikainen M; Ripatti S; Perola M; Salomaa V; Milani L; Cannon TD; Madden PAF; Korhonen T; Kaprio J; Loukola A. (Springer Nature, 2017)
      Understanding molecular processes that link comorbid traits such as addictions and mental disorders can provide novel therapeutic targets. Neuregulin signaling pathway (NSP) has previously been implicated in schizophrenia, ...
    • Neurofibromatosis type 1 is not associated with subarachnoid haemorrhage 

      Kurtelius A; Kallionpaa RA; Huttunen J; Huttunen TJ; Helin K; Koivisto T; Frosen J; zu Fraunberg MV; Peltonen S; Peltonen J; Jaaskelainen JE; Lindgren AE (Public Library of Science (PLoS), 2017)
      Background The prevalence of intracranial aneurysms (IAs) has been proposed to be elevated in the patients with neurofibromatosis type 1 (NF1). Our aims were to determine the prevalence of NF1 in a large Finnish population ...
    • Neuroimaging in animal models of epilepsy 

      Bertoglio Daniele; Verhaeghe Jeroen; Dedeurwaerdere Stefanie; Gröhn Olli (Elsevier BV, 2017)
      Epilepsy is one of the most common chronic neurological conditions worldwide. The current poor understanding and lack of reliable biomarkers of the epileptogenic process are the major limitations in the development of ...
    • Neuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease 

      Mariani MM; Malm T; Lamb R; Jay TR; Neilson L; Casali B; Medarametla L; Landreth GE (Springer Nature, 2017)
      Alzheimer’s disease (AD) is characterized by extensive neuron loss that accompanies profound impairments in memory and cognition. We examined the neuronally directed effects of the retinoid X receptor agonist bexarotene ...
    • New Insights into the Epigenetic Activities of Natural Compounds 

      Vidakovic, Melita; Marinello, Jessica; Kakkonen, Maija L; Matulis, Daumantas; Linkuviene, Vaida; Michel, Benoît Y; Navakauskiene, Ruta; Christodoulou, Michael S; Passarella, Danielle; Klimasauskas, Saulius; Blanquart, Christophe; Cuendet, Muriel; Ovadi, Judit; Poulain, Stéphane; Fontaine-Vive, Fabien; Burger, Alain; Martinet, Nadine (2018)
      Background: With their varied pharmacophores, natural products are interesting tools to open the drug discovery pipeline. Several plant secondary metabolites are components of the human diet and have reported epigenetic ...
    • New prodrugs of metformin do not influence the overall haemostasis potential and integrity of the erythrocyte membrane 

      Markowicz-Piasecka M; Sikora J; Mateusiak L; Mikiciuk-Olasik E; Huttunen KM (Elsevier BV, 2017)
      Although metformin, an oral anti-diabetic drug, has been found to have multidirectional effects over the past decade, it is characterised by unfavourable pharmacokinetic properties. This study discusses the effects of ...
    • Newtonian and Lagrangian Mechanics of a Production System 

      Estola Matti; Dannenberg Alia Asha (Hyperion University, 2016)
      We define the economic correspondents for kinetic and potential energy of production and mutually coherent Newtonian and Lagrangian frameworks for modeling production. The neoclassical theory is shown to correspond to ...
    • Nightmares as predictors of suicide: An extension study including war veterans 

      Sandman N; Valli K; Kronholm E; Vartiainen E; Laatikainen T; Paunio T (Springer Nature, 2017)
      Nightmares are intensive dreams with negative emotional tone. Frequent nightmares can pose a serious clinical problem and in 2001, Tanskanen et al. found that nightmares increase the risk of suicide. However, the dataset ...
    • No Association Between Proton Pump Inhibitor Use and Risk of Alzheimer's Disease 

      Taipale H; Tolppanen AM; Tiihonen M; Tanskanen A; Tiihonen J; Hartikainen S (Springer Nature, 2017)
      Objectives: The objective of the study was to investigate whether proton pump inhibitor (PPI) use is associated with an increased risk of clinically verified Alzheimer’s disease (AD). Methods: A Finnish nationwide ...
    • No Evidence of a Common DNA Variant Profile Specific to World Class Endurance Athletes 

      Eynon N; Filipenko ML; Garton FC; Generozov EV; Govorun VM; Houweling PJ; Kawahara T; Kostryukova ES; Kulemin NA; Larin AK; Maciejewska-Karlowska A et al. (incl. Rauramaa R) (Public Library of Science (PLoS), 2016)
      There are strong genetic components to cardiorespiratory fitness and its response to exercise training. It would be useful to understand the differences in the genomic profile of highly trained endurance athletes of world ...
    • No evidence of the role of early chemical exposure in the development of ß-cell autoimmunity 

      Salo, HM; Koponen, J; Kiviranta, H; Rantakokko, P; Honkanen, J; Härkönen, T; Ilonen, J; Virtanen, SM; Tillmann, V; Knip, M; Vaarala, O (Springer Nature America, IncSaksa, 2018)
      Exposure to environmental chemicals can modulate the developing immune system, but its role in the pathogenesis of type 1 diabetes is largely unexplored. Our objective was to study the levels of circulating concentrations ...
    • No Genetic Overlap Between Circulating Iron Levels and Alzheimer's Disease 

      Lupton MK; Benyamin B; Proitsi P; Nyholt DR; Ferreira MA; Montgomery GW; Heath AC; Madden PA; Medland SE; Gordon SD; Lovestone S; Tsolaki M; Kloszewska I; Soininen H; Mecocci P; Vellas B; Powell JF; Bush AI; Wright MJ; Martin NG; Whitfield JB (IOS Press, 2017)
      Iron deposition in the brain is a prominent feature of Alzheimer’s disease (AD). Recently, peripheral iron measures have also been shown to be associated with AD status. However, it is not known whether these associations ...
    • Non-targeted metabolite profiling reveals changes in oxidative stress, tryptophan and lipid metabolisms in fearful dogs 

      Puurunen Jenni; Tiira Katriina; Lehtonen Marko; Hanhineva Kati; Lohi Hannes (Springer Nature, 2016)
      Background Anxieties, such as shyness, noise phobia and separation anxiety, are common but poorly understood behavioural problems in domestic dogs, Canis familiaris. Although studies have demonstrated genetic and environmental ...
    • Nonconvulsive status epilepticus in rats leads to brain pathology 

      Avdic, U; Ahl, M; Chugh, D; Ali, I; Chary, K; Sierra, A; Ekdahl, CT (Wiley, 2018)
      Objective Status epilepticus (SE) is an abnormally prolonged epileptic seizure that if associated with convulsive motor symptoms is potentially life threatening for a patient. However, 20%‐40% of patients with SE lack ...
    • Novel anti-infective potential of salvianolic acid B against human serious pathogen Neisseria meningitidis 

      Huttunen Sanna; Toivanen Marko; Liu Chenghai; Tikkanen-Kaukanen Carina (BioMed Central Ltd., 2016)
      Background Epidemics of meningococcal meningitis cause significant health problems especially in Sub-Saharan Africa. Novel anti-infective candidates are needed. In modern anti-adhesion therapy initial attachment of bacteria ...
    • Novel aqueous oil-in-water emulsions containing extracts of natural coniferous resins are strongly antimicrobial against enterobacteria, staphylococci and yeasts, as well as on bacterial biofilms 

      Haapakorva, E; Holmbom, T; von Wright, A (Wiley-Blackwell, 2017)
      Aims The aim of this study was to examine the antimicrobial properties of novel aqueous natural rapeseed oil/saline emulsions containing different soluble components of spruce resin. Methods and Results The composition ...