Now showing items 882-901 of 1362

    • NAFLD risk alleles in PNPLA3, TM6SF2, GCKR, and LYPLAL1 show divergent metabolic effects 

      Sliz, Eeva; Sebert, Sylvain; Würtz, Peter; Kangas, Antti J; Soininen, Pasi; Lehtimäki, Terho; Kähönen, Mika; Viikari, Jorma; Männikkö, Minna; Ala-Korpela, Mika; Raitakari, Olli T; Kettunen, Johannes (Oxford University Press (OUP), 2018)
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    • Nanofibrillar cellulose-alginate hydrogel coated surgical sutures as cell-carrier systems 

      Laurén P; Somersalo P; Pitkänen I; Lou YR; Urtti A; Partanen J; Seppälä J; Madetoja M; Laaksonen T; Mäkitie A; Yliperttula M (Public Library of Science (PLoS), 2017)
      Hydrogel nanomaterials, especially those that are of non-human and non-animal origins, have great potential in biomedical and pharmaceutical sciences due to their versatility and inherent soft-tissue like properties. With ...

    • National Current Care Guidelines for paediatric lower respiratory tract infections reduced the use of chest radiographs but local variations were observed 

      Poutanen, Roope; Virta, Tuija; Heikkilä, Paula; Pauniaho, Satu-Liisa; Csonka, Peter; Korppi, Matti; Renko, Marjo; Palmu, Sauli (Wiley, 2020)
      Aim Our aim was to evaluate the impact of the 2014 Finnish Current Care Guidelines for paediatric lower respiratory tract infections (LRTIs), particularly on taking of chest radiographs. Methods This study used official ...
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    • Natriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis 

      Natriuretic Peptides Studies Collaboration; Willeit P; Kaptoge S; Welsh P; Butterworth AS; Chowdhury R; Spackman SA; Pennells L; Gao P; Burgess S; Freitag DF; Sweeting M; Wood AM; Cook NR; Judd S; Trompet S; Nambi V; Olsen MH; Everett BM; Kee F et al. (Elsevier BV, 2016)
      Background Guidelines for primary prevention of cardiovascular diseases focus on prediction of coronary heart disease and stroke. We assessed whether or not measurement of N-terminal-pro-B-type natriuretic peptide (NT-proBNP) ...

    • Natural polyphenols as sirtuin 6 modulators 

      Rahnasto-Rilla, M; Tyni, J; Huovinen, M; Jarho, E; Kulikowicz, T; Ravichandran, S; Bohr, VA; Ferrucci, L; Lahtela-Kakkonen, M; Moaddel R (Springer Nature, 2018)
      Flavonoids are polyphenolic secondary metabolites synthesized by plants and fungus with various pharmacological effects. Due to their plethora of biological activities, they have been studied extensively in drug development. ...
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    • Neuregulin signaling pathway in smoking behavior 

      Gupta R; Qaiser B; He L; Hiekkalinna TS; Zheutlin AB; Therman S; Ollikainen M; Ripatti S; Perola M; Salomaa V; Milani L; Cannon TD; Madden PAF; Korhonen T; Kaprio J; Loukola A. (Springer Nature, 2017)
      Understanding molecular processes that link comorbid traits such as addictions and mental disorders can provide novel therapeutic targets. Neuregulin signaling pathway (NSP) has previously been implicated in schizophrenia, ...

    • Neurofibromatosis type 1 is not associated with subarachnoid haemorrhage 

      Kurtelius A; Kallionpaa RA; Huttunen J; Huttunen TJ; Helin K; Koivisto T; Frosen J; zu Fraunberg MV; Peltonen S; Peltonen J; Jaaskelainen JE; Lindgren AE (Public Library of Science (PLoS), 2017)
      Background The prevalence of intracranial aneurysms (IAs) has been proposed to be elevated in the patients with neurofibromatosis type 1 (NF1). Our aims were to determine the prevalence of NF1 in a large Finnish population ...

    • Neuroimaging in animal models of epilepsy 

      Bertoglio Daniele; Verhaeghe Jeroen; Dedeurwaerdere Stefanie; Gröhn Olli (Elsevier BV, 2017)
      Epilepsy is one of the most common chronic neurological conditions worldwide. The current poor understanding and lack of reliable biomarkers of the epileptogenic process are the major limitations in the development of ...

    • Neuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease 

      Mariani MM; Malm T; Lamb R; Jay TR; Neilson L; Casali B; Medarametla L; Landreth GE (Springer Nature, 2017)
      Alzheimer’s disease (AD) is characterized by extensive neuron loss that accompanies profound impairments in memory and cognition. We examined the neuronally directed effects of the retinoid X receptor agonist bexarotene ...

    • Neurorepair Strategies After Stroke 

      Zhao, Chuansheng; Jolkkonen, Jukka (Springer Singapore, 2020)
      The emerging understandings on brain repair and plasticity have important implications for the development of neurorepair strategies in stroke. Peri-infarct tissue undergoes a major reorganization after an ischemic event ...
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    • Neurotropism of SARS-CoV-2 and its neuropathological alterations: Similarities with other coronaviruses 

      Hu, Jingman; Jolkkonen, Jukka; Zhao, Chuansheng (Elsevier BV, 2020)
      A novel coronavirus (SARS-CoV-2) emerged from Wuhan, China, and spread quickly around the world. In addition to fever, cough and shortness of breath, it was confirmed that the patients also have manifestations towards the ...
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    • New Implications for the Role for Ubiquilin-1 in Molecular Mechanisms of Alzheimer's Disease: Interrelationship with BACE1 

      Takalo Mari; Natunen Teemu; Leskelä Stina; Paldanius Kaisa MA; Soininen Hilkka; Hiltunen MIkko; Haapasalo Annakaisa (2017)
      Ample evidence links ubiquilins to the pathogenesis of various neurodegenerative disorders. Ubiquilin-1 (also called PLIC-1) is associated to the pathogenesis of Alzheimer’s disease (AD) both genetically and functionally ...
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    • New Insights into the Epigenetic Activities of Natural Compounds 

      Vidakovic, Melita; Marinello, Jessica; Kakkonen, Maija L; Matulis, Daumantas; Linkuviene, Vaida; Michel, Benoît Y; Navakauskiene, Ruta; Christodoulou, Michael S; Passarella, Danielle; Klimasauskas, Saulius; Blanquart, Christophe; Cuendet, Muriel; Ovadi, Judit; Poulain, Stéphane; Fontaine-Vive, Fabien; Burger, Alain; Martinet, Nadine (2018)
      Background: With their varied pharmacophores, natural products are interesting tools to open the drug discovery pipeline. Several plant secondary metabolites are components of the human diet and have reported epigenetic ...
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    • New insights into the genetic basis of premature ovarian insufficiency: novel causative variants and candidate genes revealed by genomic sequencing 

      Jaillard, Sylvie; Bell, Katrina; Akloul, Linda; Walton, Kelly; McElreavy, Kenneth; Stocker, William A; Beaumont, Marion; Harrisson, Craig; Jääskeläinen, Tiina; Palvimo, Jorma J; Robevska, Gorjana; Launay, Erika; Satié, Anne-Pascale; Listyasari, Nurin; Bendavid, Claude; Sreenivasan, Rajini; Duros, Solène; van den Bergen, Jocelyn, Henry, Catherine; Domin-Bernhard, Mathilde; et al. (Elsevier BV, 2020)
      Ovarian deficiency, including premature ovarian insufficiency (POI) and diminished ovarian reserve (DOR), represents one of the main causes of female infertility. POI is a genetically heterogeneous condition but current ...
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    • New prodrugs of metformin do not influence the overall haemostasis potential and integrity of the erythrocyte membrane 

      Markowicz-Piasecka M; Sikora J; Mateusiak L; Mikiciuk-Olasik E; Huttunen KM (Elsevier BV, 2017)
      Although metformin, an oral anti-diabetic drug, has been found to have multidirectional effects over the past decade, it is characterised by unfavourable pharmacokinetic properties. This study discusses the effects of ...

    • Newtonian and Lagrangian Mechanics of a Production System 

      Estola Matti; Dannenberg Alia Asha (Hyperion University, 2016)
      We define the economic correspondents for kinetic and potential energy of production and mutually coherent Newtonian and Lagrangian frameworks for modeling production. The neoclassical theory is shown to correspond to ...

    • Nightmares as predictors of suicide: An extension study including war veterans 

      Sandman N; Valli K; Kronholm E; Vartiainen E; Laatikainen T; Paunio T (Springer Nature, 2017)
      Nightmares are intensive dreams with negative emotional tone. Frequent nightmares can pose a serious clinical problem and in 2001, Tanskanen et al. found that nightmares increase the risk of suicide. However, the dataset ...

    • Nine Amino Acids are Associated with Decreased Insulin Secretion and Elevated Glucose Levels in a 4.6-Year Follow-Up Study of 5,181 Finnish Men 

      Vangipurapu, J; Stancáková, A; Smith, U; Kuusisto, J; Laakso, M (American Diabetes Association, 2019)
      Several amino acids (AAs) have been shown to be associated with insulin resistance and increased risk of type 2 diabetes, but no previous studies have investigated the association of AAs with insulin secretion in a ...
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    • No Association Between Proton Pump Inhibitor Use and Risk of Alzheimer's Disease 

      Taipale H; Tolppanen AM; Tiihonen M; Tanskanen A; Tiihonen J; Hartikainen S (Springer Nature, 2017)
      Objectives: The objective of the study was to investigate whether proton pump inhibitor (PPI) use is associated with an increased risk of clinically verified Alzheimer’s disease (AD). Methods: A Finnish nationwide ...

    • No Evidence of a Common DNA Variant Profile Specific to World Class Endurance Athletes 

      Eynon N; Filipenko ML; Garton FC; Generozov EV; Govorun VM; Houweling PJ; Kawahara T; Kostryukova ES; Kulemin NA; Larin AK; Maciejewska-Karlowska A et al. (incl. Rauramaa R) (Public Library of Science (PLoS), 2016)
      There are strong genetic components to cardiorespiratory fitness and its response to exercise training. It would be useful to understand the differences in the genomic profile of highly trained endurance athletes of world ...
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