Browsing Terveystieteiden tiedekunta by Title

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    • Neuropsykologinen tutkimus ja Alzheimerin tautia sairastavan testamentintekokelpoisuus 

      Jehkonen, Mervi; Mäki-Petäjä-Leinonen, Anna (Suomalainen lääkäriseura Duodecim, 2019)
      Suomessa ei ole yhtenäistä käytäntöä muistisairaan testamentintekokelpoisuuden arvioimiseksi. Nykykäytännön mukaan asianajaja ja tuomioistuin voivat pyytää testamentintekokelpoisuuden arviointiin lääkärinlausunnon. Lääkäri ...
      Tieteelliset aikakauslehtiartikkelit

    • Neurorepair Strategies After Stroke 

      Zhao, Chuansheng; Jolkkonen, Jukka (Springer Singapore, 2020)
      The emerging understandings on brain repair and plasticity have important implications for the development of neurorepair strategies in stroke. Peri-infarct tissue undergoes a major reorganization after an ischemic event ...
      Artikkelit tieteellisissä kokoomateoksissa

    • Neurotropism of SARS-CoV-2 and its neuropathological alterations: Similarities with other coronaviruses 

      Hu, Jingman; Jolkkonen, Jukka; Zhao, Chuansheng (Elsevier BV, 2020)
      A novel coronavirus (SARS-CoV-2) emerged from Wuhan, China, and spread quickly around the world. In addition to fever, cough and shortness of breath, it was confirmed that the patients also have manifestations towards the ...
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    • New Enhancement beyond Radiation Field Improves Survival Prediction in Patients with Post-Treatment High-Grade Glioma 

      Yuan, Tao; Ji, Xiaoli; Liu, Yawu; Gao, Guodong; Ren, Jia-Liang; Huang, Deyou; Quan, Guanmin (Hindawi Limited, 2021)
      The imaging signs which can accurately predict survival prognosis after standard treatment of high-grade glioma (HGG) are highly desirable. This study aims to explore the role of new enhancement beyond radiation field ...
      Tieteelliset aikakauslehtiartikkelit

    • New Implications for the Role for Ubiquilin-1 in Molecular Mechanisms of Alzheimer's Disease: Interrelationship with BACE1 

      Takalo Mari; Natunen Teemu; Leskelä Stina; Paldanius Kaisa MA; Soininen Hilkka; Hiltunen MIkko; Haapasalo Annakaisa (2017)
      Ample evidence links ubiquilins to the pathogenesis of various neurodegenerative disorders. Ubiquilin-1 (also called PLIC-1) is associated to the pathogenesis of Alzheimer’s disease (AD) both genetically and functionally ...
      Tieteelliset aikakauslehtiartikkelit

    • New Insights into the Epigenetic Activities of Natural Compounds 

      Vidakovic, Melita; Marinello, Jessica; Kakkonen, Maija L; Matulis, Daumantas; Linkuviene, Vaida; Michel, Benoît Y; Navakauskiene, Ruta; Christodoulou, Michael S; Passarella, Danielle; Klimasauskas, Saulius; Blanquart, Christophe; Cuendet, Muriel; Ovadi, Judit; Poulain, Stéphane; Fontaine-Vive, Fabien; Burger, Alain; Martinet, Nadine (2018)
      Background: With their varied pharmacophores, natural products are interesting tools to open the drug discovery pipeline. Several plant secondary metabolites are components of the human diet and have reported epigenetic ...
      Tieteelliset aikakauslehtiartikkelit

    • New insights into the genetic basis of premature ovarian insufficiency: novel causative variants and candidate genes revealed by genomic sequencing 

      Jaillard, Sylvie; Bell, Katrina; Akloul, Linda; Walton, Kelly; McElreavy, Kenneth; Stocker, William A; Beaumont, Marion; Harrisson, Craig; Jääskeläinen, Tiina; Palvimo, Jorma J; Robevska, Gorjana; Launay, Erika; Satié, Anne-Pascale; Listyasari, Nurin; Bendavid, Claude; Sreenivasan, Rajini; Duros, Solène; van den Bergen, Jocelyn, Henry, Catherine; Domin-Bernhard, Mathilde; et al. (Elsevier BV, 2020)
      Ovarian deficiency, including premature ovarian insufficiency (POI) and diminished ovarian reserve (DOR), represents one of the main causes of female infertility. POI is a genetically heterogeneous condition but current ...
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    • New insights into the genetic etiology of Alzheimer’s disease and related dementias 

      Bellenguez, Céline; Küçükali, Fahri; Jansen, Iris E; Kleineidam, Luca; Moreno-Grau, Sonia; Amin, Najaf; Naj, Adam C; Campos-Martin, Rafael; Grenier-Boley, Benjamin; Andrade, Victor; Holmans, Peter A; Boland, Anne; Damotte, Vincent; van der Lee, Sven J; Costa, Marcos R; Kuulasmaa, Teemu; Yang, Qiong; de Rojas, Itziar; Bis, Joshua C; Yaqub, Amber; et al. (incl. Hiltunen, Mikko; Haapasalo, Annakaisa; Soininen, Hilkka; Solomon, Alina; Helisalmi, Seppo; Kivipelto, Miia; Lehtisalo, Jenni; Koivisto, Anne) (Springer Nature, 2022)
      Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a ...

    • New prodrugs of metformin do not influence the overall haemostasis potential and integrity of the erythrocyte membrane 

      Markowicz-Piasecka M; Sikora J; Mateusiak L; Mikiciuk-Olasik E; Huttunen KM (Elsevier BV, 2017)
      Although metformin, an oral anti-diabetic drug, has been found to have multidirectional effects over the past decade, it is characterised by unfavourable pharmacokinetic properties. This study discusses the effects of ...
      info:eu-repo/semantics/article

    • Newtonian and Lagrangian Mechanics of a Production System 

      Estola Matti; Dannenberg Alia Asha (Hyperion University, 2016)
      We define the economic correspondents for kinetic and potential energy of production and mutually coherent Newtonian and Lagrangian frameworks for modeling production. The neoclassical theory is shown to correspond to ...
      info:eu-repo/semantics/article

    • Nifedipine disturbs fetal cardiac function during hypoxemia in a chronic sheep model at near term gestation 

      Alanne, Leena; Bhide, Amarnath; Lantto, Juulia; Huhta, Heikki; Kokki, Merja; Haapsamo, Mervi; Acharya, Ganesh; Räsänen, Juha (Elsevier BV, 2021)
      Background Nifedipine is a widely used drug in pregnancies complicated by maternal hypertensive disorders that can be associated with placental insufficiency and fetal hypoxemia. The evidence regarding fetal myocardial ...
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    • Nightmares as predictors of suicide: An extension study including war veterans 

      Sandman N; Valli K; Kronholm E; Vartiainen E; Laatikainen T; Paunio T (Springer Nature, 2017)
      Nightmares are intensive dreams with negative emotional tone. Frequent nightmares can pose a serious clinical problem and in 2001, Tanskanen et al. found that nightmares increase the risk of suicide. However, the dataset ...
      info:eu-repo/semantics/article

    • Nine Amino Acids are Associated with Decreased Insulin Secretion and Elevated Glucose Levels in a 4.6-Year Follow-Up Study of 5,181 Finnish Men 

      Vangipurapu, J; Stancáková, A; Smith, U; Kuusisto, J; Laakso, M (American Diabetes Association, 2019)
      Several amino acids (AAs) have been shown to be associated with insulin resistance and increased risk of type 2 diabetes, but no previous studies have investigated the association of AAs with insulin secretion in a ...
      Tieteelliset aikakauslehtiartikkelit

    • No Association Between Proton Pump Inhibitor Use and Risk of Alzheimer's Disease 

      Taipale H; Tolppanen AM; Tiihonen M; Tanskanen A; Tiihonen J; Hartikainen S (Springer Nature, 2017)
      Objectives: The objective of the study was to investigate whether proton pump inhibitor (PPI) use is associated with an increased risk of clinically verified Alzheimer’s disease (AD). Methods: A Finnish nationwide ...
      info:eu-repo/semantics/article

    • No Evidence of a Common DNA Variant Profile Specific to World Class Endurance Athletes 

      Eynon N; Filipenko ML; Garton FC; Generozov EV; Govorun VM; Houweling PJ; Kawahara T; Kostryukova ES; Kulemin NA; Larin AK; Maciejewska-Karlowska A et al. (incl. Rauramaa R) (Public Library of Science (PLoS), 2016)
      There are strong genetic components to cardiorespiratory fitness and its response to exercise training. It would be useful to understand the differences in the genomic profile of highly trained endurance athletes of world ...
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    • No evidence of the role of early chemical exposure in the development of ß-cell autoimmunity 

      Salo, HM; Koponen, J; Kiviranta, H; Rantakokko, P; Honkanen, J; Härkönen, T; Ilonen, J; Virtanen, SM; Tillmann, V; Knip, M; Vaarala, O (Springer Nature America, Inc, 2018)
      Exposure to environmental chemicals can modulate the developing immune system, but its role in the pathogenesis of type 1 diabetes is largely unexplored. Our objective was to study the levels of circulating concentrations ...
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    • No Genetic Overlap Between Circulating Iron Levels and Alzheimer's Disease 

      Lupton MK; Benyamin B; Proitsi P; Nyholt DR; Ferreira MA; Montgomery GW; Heath AC; Madden PA; Medland SE; Gordon SD; Lovestone S; Tsolaki M; Kloszewska I; Soininen H; Mecocci P; Vellas B; Powell JF; Bush AI; Wright MJ; Martin NG; Whitfield JB (IOS Press, 2017)
      Iron deposition in the brain is a prominent feature of Alzheimer’s disease (AD). Recently, peripheral iron measures have also been shown to be associated with AD status. However, it is not known whether these associations ...
      info:eu-repo/semantics/article

    • Non-targeted metabolite profiling reveals changes in oxidative stress, tryptophan and lipid metabolisms in fearful dogs 

      Puurunen Jenni; Tiira Katriina; Lehtonen Marko; Hanhineva Kati; Lohi Hannes (Springer Nature, 2016)
      Background Anxieties, such as shyness, noise phobia and separation anxiety, are common but poorly understood behavioural problems in domestic dogs, Canis familiaris. Although studies have demonstrated genetic and environmental ...
      info:eu-repo/semantics/article

    • Nonconvulsive status epilepticus in rats leads to brain pathology 

      Avdic, U; Ahl, M; Chugh, D; Ali, I; Chary, K; Sierra, A; Ekdahl, CT (Wiley, 2018)
      Objective Status epilepticus (SE) is an abnormally prolonged epileptic seizure that if associated with convulsive motor symptoms is potentially life threatening for a patient. However, 20%‐40% of patients with SE lack ...
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    • Normaalipaineisen hydrokefaluksen kliininen kuva, diagnostiset tutkimukset ja hoito 

      Leinonen, Ville; Junkkari, Antti; Rauramaa, Tuomas; Jääskeläinen, Juha E; Vanninen, Ritva; Savolainen, Sakari; Hiltunen, Mikko; Remes, Anne M; Koivisto, Anne M (Suomalainen lääkäriseura Duodecim, 2019)
      Akuutti hydrokefalus on kaikenikäisille henkeä uhkaava tila. Mikäli epäillään sunttiriippuvaisen potilaan suntin toimintahäiriötä, on pään tietokonetomografia (TT) tai magneettikuvaus tehtävä viipymättä ja tarvittaessa ...
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