Browsing Terveystieteiden tiedekunta by Title
Now showing items 1325-1344 of 1735
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Psykoosilääkehoidon ohjaus voi tehostaa skitsofrenian hoitoa
(Suomalainen lääkäriseura Duodecim, 2022)Psykoosilääkkeet lievittävät skitsofrenian psykoosioireita ja vähentävät relapsiriskiä. Psykoosilääkityksen pitkäaikaiskäytön hyöty-haittasuhde skitsofrenian hoidossa on osin tuntematon. Etenkin suurten psykoosilääkeannosten ...
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Psyykenlääkkeet ja sydän
(Suomalainen lääkäriseura Duodecim, 2020)Monet masennus- ja psykoosilääkkeet pidentävät QT-aikaa ja voivat siten altistaa käyttäjänsä äkkikuolemalle. Näiden lääkkeiden aloitus edellyttää riskinarviointia ja jatkuva käyttö muun muassa EKG-seurantaa. Varsinkin ...Tieteelliset aikakauslehtiartikkelit
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Pulse-echo ultrasound method for detection of post-menopausal women with osteoporotic BMD
(Springer Nature, 2018)Summary We lack effective diagnostics of osteoporosis at the primary health care level. An ultrasound device was used to identify subjects in the osteoporotic range as defined by DXA. A case finding strategy combining ...Tieteelliset aikakauslehtiartikkelit
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Purchases of medical therapy recommended for coronary artery disease before and after elective revascularisation
(Springer Science and Business Media LLC, 2020)Aims We studied the purchases of medical therapy recommended for coronary artery disease patients before and after elective revascularisation (percutaneous coronary intervention (PCI) or coronary bypass grafting ...Tieteelliset aikakauslehtiartikkelit
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Purinergic Profiling of Regulatory T-cells in Patients With Episodic Migraine
(Frontiers Media SA, 2018)Objectives: Immune responses in migraine are poorly characterized, yet implicated in the disease pathogenesis. This study was carried out to characterize purinergic profiles of T-cells in patients with episodic migraine ...Tieteelliset aikakauslehtiartikkelit
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Putative metabolites involved in the beneficial effects of wholegrain cereal: Nontargeted metabolite profiling approach
(Elsevier BV, 2021)Background and aims Wholegrain cereals have been implicated in the reduction of lifestyle-related chronic diseases risk including cardiovascular diseases and type 2 diabetes. Molecular mechanisms responsible for the ...Tieteelliset aikakauslehtiartikkelit
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Pyridinylimidazoles as dual glycogen synthase kinase 3ß/p38[alpha] mitogen-activated protein kinase inhibitors
(Elsevier BV, 2019)Compounds simultaneously inhibiting two targets that are involved in the progression of the same complex disease may exhibit additive or even synergistic therapeutic effects. Here we unveil 2,4,5-trisubstituted imidazoles ...Tieteelliset aikakauslehtiartikkelit
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Quality improvement activity in occupational healthcare associated with reduced need for disability retirement: A Bayesian mixed effects modelling study in Finland
(, 2020)Objectives There is evidence that occupational healthcare (OHC) may improve employees’ work ability. This research was designed to study whether common quality improvement (QI) activities in the OHC quality network (OQN) ...Tieteelliset aikakauslehtiartikkelit
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Quality of care and patient safety at healthcare institutions in Oman: quantitative study of the perspectives of patients and healthcare professionals
(Springer Science and Business Media LLC, 2021)Background Oman’s healthcare system has rapidly transformed in recent years. A recent Report of Quality and Patient Safety has nevertheless highlighted decreasing levels of patient safety and quality culture among healthcare ...Tieteelliset aikakauslehtiartikkelit
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Quality of surgical patient-reported outcome measure (PROM) validation studies is often deficient: A systematic review
(Elsevier Inc, 2023)Objectives To examine the methodological basis behind the conclusions of patient-reported outcome measure (PROM) validation studies. Study Design and Setting A systematic review was performed on surgical studies ...
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Quantification of anisotropy and orientation in 3D electron microscopy and diffusion tensor imaging in injured rat brain
(Elsevier BV, 2018)Diffusion tensor imaging (DTI) reveals microstructural features of grey and white matter non-invasively. The contrast produced by DTI, however, is not fully understood and requires further validation. We used serial ...Tieteelliset aikakauslehtiartikkelit
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Quantification of myocardial infarct area based on TRAFFn relaxation time maps - comparison with cardiovascular magnetic resonance late gadolinium enhancement, T1p and T2 in vivo
(Springer Nature, 2018)Background Two days after myocardial infarction (MI), the infarct consists mostly on necrotic tissue, and the myocardium is transformed through granulation tissue to scar in two weeks after the onset of ischemia in mice. ...Tieteelliset aikakauslehtiartikkelit
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Quantitative Evaluation of the Mechanical Risks Caused by Focal Cartilage Defects in the Knee
(Springer Nature, 2016)Focal cartilage lesions can proceed to severe osteoarthritis or remain unaltered even for years. A method to identify high risk defects would be of utmost importance to guide clinical decision making and to identify the ...info:eu-repo/semantics/article
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Quantitative Longitudinal Predictions of Alzheimer's Disease by Multi-Modal Predictive Learning
(IOS Press, 2021)Background: Quantitatively predicting the progression of Alzheimer’s disease (AD) in an individual on a continuous scale, such as the Alzheimer’s Disease Assessment Scale-cognitive (ADAS-cog) scores, is informative for a ...Tieteelliset aikakauslehtiartikkelit
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Quantitative pharmacokinetic analyses of anterior and posterior elimination routes of intravitreal anti-VEGF macromolecules using published human and rabbit data
(Elsevier Ltd, 2022)The purpose of this study was to evaluate the contribution of the anterior elimination route for four anti-vascular endothelial growth factor (anti-VEGF) macromolecules (aflibercept, bevacizumab, pegaptanib and ranibizumab) ...
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Quantitative Serum Nuclear Magnetic Resonance Metabolomics in Large-Scale Epidemiology : a Primer on -Omic Technologies
(Oxford University Press (OUP), 2017)Detailed metabolic profiling in large-scale epidemiologic studies has uncovered novel biomarkers for cardiometabolic diseases and clarified the molecular associations of established risk factors. A quantitative metabolomics ...info:eu-repo/semantics/article
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Quantitative susceptibility mapping of the rat brain after traumatic brain injury
(Wiley, 2021)The primary lesion arising from the initial insult after traumatic brain injury (TBI) triggers a cascade of secondary tissue damage, which may also progress to connected brain areas in the chronic phase. The aim of this ...Tieteelliset aikakauslehtiartikkelit
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Quantitative urine proteomics in pregnant women for the identification of predictive biomarkers for preeclampsia
(BioMed Central Ltd, 2022)Background Preeclampsia (PE) is a life-threatening disease characterized by elevated blood pressure and proteinuria. Predictive biomarkers of PE are needed, especially those predicting PE in early pregnancy. The aim of ...
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Quinazoline-based anti-virulence compounds selectively target Salmonella PhoP/PhoQ signal transduction system
(American Society for Microbiology, 2020)The rapid emergence of multidrug resistance among bacterial pathogens has become a significant challenge to human health in our century. Therefore, development of next-generation antibacterial compounds is an urgent need. ...Tieteelliset aikakauslehtiartikkelit
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Radiotherapy-induced vascular cognitive impairment 20 years after childhood brain tumor
(Oxford University Press on behalf of the Society for Neuro-Oncology, 2024)Background Studies have established that radiotherapy for childhood brain tumors (BTs) increases the risk of cerebrovascular disease (CVD); however, it is unclear how this will affect cognitive function. This study aimed ...