Browsing Terveystieteiden tiedekunta by Title

Now showing items 219-238 of 1735

    • Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-3 

      Mangoni, AA; Tuccanardi, T; Collina, S; Vanden Eynde, JJ; Muñoz-Torrero, D; Karaman, R; Siciliano, C; de Sousa, ME; Prokai-Tatrai, K; Rautio, J; Guillou, C; Gütschow, M; Galdiero, S; Liu, H; Agrofoglio, LA; Sabatier, JM; Hulme, C; Kokotos, G; You, Q; Gomes, PAC (MDPI AG, 2018)
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    • Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes¿4 

      Mangoni, AA; Guillou, C; Vanden Eynde, JJ; Hulme, C; Jampilek, J; Li, W; Prokai-Tatrai, K; Rautio, J; Collina, S; Tuccinardi, T; Sousa, ME; Sabatier, JM; Galdiero, S; Karaman, R; Kokotos, G; Torri, G; Luque, FJ; Vasconcelos, MH; Hadjipavlou-Litina, D; Siciliano, C; et al (MDPI AG, 2018)
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    • Brief isoflurane anesthesia regulates striatal AKT-GSK3ß signaling and ameliorates motor deficits in a rat model of early-stage Parkinson's disease 

      Leikas J V; Kohtala S; Theilmann W; Jalkanen A J; Forsberg M M; Rantamäki T (Wiley-Blackwell, 2017)
      Parkinson's disease (PD) is a progressive neurodegenerative movement disorder primarily affecting the nigrostriatal dopaminergic system. The link between heightened activity of glycogen synthase kinase 3β (GSK3β) and ...
      info:eu-repo/semantics/article

    • Brown Adipose Tissue Energy Metabolism in Humans 

      Carpentier, Andre C; Blondin, Denis P; Virtanen, Kirsi A; Richard, Denis; Haman, Francois; Turcotte, Eric E (Frontiers Media SA, 2018)
      The demonstration of metabolically active brown adipose tissue (BAT) in humans primarily using positron emission tomography coupled to computed tomography (PET/CT) with the glucose tracer 18-fluorodeoxyglucose (18FDG) has ...
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    • Burden of disease due to transportation noise in the Nordic countries 

      Aasvang, Gunn Marit; Stockfelt, Leo; Sørensen, Mette; Turunen, Anu W; Roswall, Nina; Yli-Tuomi, Tarja; Ögren, Mikael; Lanki, Timo; Selander, Jenny; Vincens, Natalia; Pyko, Andrei; Pershagen, Göran; Sulo, Gerhard; Bølling, Anette Kocbach (Elsevier Inc, 2023)
      Background Environmental noise is of increasing concern for public health. Quantification of associated health impacts is important for regulation and preventive strategies. Aim To estimate the burden of disease (BoD) ...

    • Burns pain management: The role of nurse-patient communication 

      Tetteh, Linda; Aziato, Lydia; Mensah, Gwendolyn Patience; Vehviläinen-Julkunen, Katri; Kwegyir-Afful, Emma (Elsevier BV, 2021)
      Background Nursing is an embodiment of knowledge, clinical work, and interpersonal communication. Effective nursing care has a distinct influence on the overall satisfaction and experience of the patient. Communication ...
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    • C9orf72 hexanucleotide repeat expansion leads to altered neuronal and dendritic spine morphology and synaptic dysfunction 

      Huber, Nadine; Hoffmann, Dorit; Giniatullina, Raisa; Rostalski, Hannah; Leskelä, Stina; Takalo, Mari; Natunen, Teemu; Solje, Eino; Remes, Anne M.; Giniatullin, Rashid; Hiltunen, Mikko; Haapasalo, Annakaisa (Elsevier BV, 2022)
      Frontotemporal lobar degeneration (FTLD) comprises a heterogenous group of progressive neurodegenerative syndromes. To date, no validated biomarkers or effective disease-modifying therapies exist for the different clinical ...
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    • Caffeine content in newborn hair correlates with maternal dietary intake 

      Lehtonen, Anni; Uusitalo, Lauri; Auriola, Seppo; Backman, Katri; Heinonen, Seppo; Keski-Nisula, Leea; Pasanen, Markku; Pekkanen, Juha; Tuomainen, Tomi-Pekka; Voutilainen, Raimo; Hantunen, Sari; Lehtonen, Marko (Springer Science and Business Media LLC, 2021)
      Purpose High-maternal caffeine intake during pregnancy may be harmful for perinatal outcomes and future child health, but the level of fetal cumulative exposure has been difficult to measure thus far. Here, we present ...
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    • CAIDE dementia risk score, Alzheimer and cerebrovascular pathology: a population-based autopsy study 

      Hooshmand, B; Polvikoski, T; Kivipelto, M; Tanskanen, M; Myllykangas, L; Mäkelä, M; Oinas, M; Paetau, A; Solomon, A (Wiley-Blackwell, 2018)
      Background CAIDE Dementia Risk Score is a tool for estimating dementia risk in the general population. Its longitudinal associations with Alzheimer or vascular neuropathology in the oldest old are not known. Aim To ...
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    • Call for Papers in the Area of Cardiovascular Regenerative Medicine 

      Ylä-Herttuala Seppo (Elsevier BV, 2017)
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    • Camelina Sativa Oil, but not Fatty Fish or Lean Fish, Improves Serum Lipid Profile in Subjects with Impaired Glucose Metabolism - A Randomized Controlled Trial 

      Schwab, Ursula Sonja; Erkkilä, Arja; Kurl, Sudhir; Lankinen, Maria; de Mello Laaksonen, Vanessa (Wiley-Blackwell, 2018)
      Scope The aim of the study is to examine whether lean fish (LF), fatty fish (FF), and camelina sativa oil (CSO), a plant-based source of alpha-linolenic acid (ALA), differ in their metabolic effects in subjects with ...
      article

    • Camelina sativa oil, fatty fish or lean fish do not markedly affect urinary prostanoids in subjects with impaired glucose metabolism 

      Erkkilä, AT; Lee, JC; Lankinen, M; Manninen, S; Leung ,HH; Oger, C; de Mello, VD; Schwab, US (Wiley, 2019)
      Dietary fatty acids are suggested to affect oxidative stress; however, results from interventions have been inconclusive. The aim was to examine if fatty fish, lean fish, and Camelina sativa oil (CSO) affect the urinary ...
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    • Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database . 

      Møller, P; Seppälä, TT; Bernstein, I; Holinski-Feder, E; Sala, P; Gareth Evans, D; Lindblom, A; Macrae, F; Blanco, I; Sijmons, RH; Jeffries, J; Vasen, HFA; Burn, J; Nakken, S; Hovig, E; Rødland, EA; Tharmaratnam, K; de Vos Tot, Nederveen Cappel, WH; Hill, J; et al [Incl Mecklin, J-P] in collaboration with The Mallorca Group (BMJ, 2018)
      Background Most patients with path_MMR gene variants (Lynch syndrome (LS)) now survive both their first and subsequent cancers, resulting in a growing number of older patients with LS for whom limited information exists ...
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    • Carboxylesterase Activities and Protein Expression in Rabbit and Pig Ocular Tissues 

      Hammid, Anam; Fallon, John K; Lassila, Toni; Salluce, Giulia; Smith, Philip C; Tolonen, Ari; Sauer, Achim; Urtti, Arto; Honkakoski, Paavo (American Chemical Society (ACS), 2021)
      Hydrolytic reactions constitute an important pathway of drug metabolism and a significant route of prodrug activation. Many ophthalmic drugs and prodrugs contain ester groups that greatly enhance their permeation across ...
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    • Cardiac Actions of a Small Molecule Inhibitor Targeting GATA4-NKX2-5 Interaction 

      Kinnunen, SM; Tölli, M; Välimäki, MJ; Gao, E; Szabo, Z; Rysä, J; Ferreira, MPA; Ohukainen, P; Serpi, R; Correia, A; Mäkilä, E; Salonen, J; Hirvonen, J; Santos, HA; Ruskoaho, H (Springer Nature, 2018)
      Transcription factors are fundamental regulators of gene transcription, and many diseases, such as heart diseases, are associated with deregulation of transcriptional networks. In the adult heart, zinc-finger transcription ...
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    • Cardiac Lymphatics - A New Avenue for Therapeutics? 

      Vuorio Taina; Tirronen Annakaisa; Ylä-Herttuala Seppo (Elsevier BV, 2017)
      Recent progress in lymphatic vessel biology and in novel imaging techniques has established the importance of the lymphatic vasculature as part of the cardiovascular system. The lymphatic vessel network regulates many ...
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    • Cardiac repolarization during fingolimod treatment in patients with relapsing-remitting multiple sclerosis 

      Laiho, Aapo; Laitinen, Tiina M; Hartikainen, Paivi; Hartikainen, Juha E K; Laitinen, Tomi P; Simula, Sakari (Wiley-Blackwell, 2018)
      Background Fingolimod is a sphingosine‐1‐phosphate receptor modulator for the treatment of relapsing–remitting multiple sclerosis (RRMS). Despite an established effect on heart rate, the effect of fingolimod on cardiac ...
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    • Cardiac repolarization evolves differently during the course of benign and disabling multiple sclerosi 

      Mikkola, Alma; Ojanen, Aku; Hartikainen, Juha EK; Remes, Anne M; Simula, Sakari (Elsevier BV, 2018)
      Background Cardiac repolarization is modulated by the autonomic nervous system. Even though multiple sclerosis associates with prolonged cardiac repolarization the physiology responsible for the phenomenon remains ...
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    • Cardiometabolic Risk Profile Among Young Adult Females With a History of Premature Adrenarche 

      Liimatta, J; Utriainen, P; Laitinen, T; Voutilainen, R; Jääskeläinen, J (The Endocrine Society, 2019)
      There were no differences in the prevalence of MetS or in any parameters indicating dyslipidemia, hypertension, hepatosteatosis, atherosclerosis, or low-grade inflammation between the study groups. However, prevalence of ...
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    • Cardiopulmonary Exercise Testing in Pediatrics 

      Takken Tim; Bongers Bart C; van Brussel Marco; Haapala Eero A; Hulzebos Erik HJ (American Thoracic Society, 2017)
      Aerobic fitness is an important determinant of overall health. Higher aerobic fitness has been associated with many health benefits. Because myocardial ischemia is rare in children, indications for exercise testing differ ...
      info:eu-repo/semantics/article