Browsing Terveystieteiden tiedekunta by Title
Now showing items 317-336 of 1735
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Common Genetic Variation Near Melatonin Receptor 1A Gene Linked to Job-Related Exhaustion in Shift Workers
(Oxford University Press (OUP), 2017)Study Objectives: Tolerance to shift work varies; only some shift workers suffer from disturbed sleep, fatigue, and job-related exhaustion. Our aim was to explore molecular genetic risk factors for intolerance to shift ...info:eu-repo/semantics/article
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Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study
(Public Library of Science (PLoS), 2017)Lipid and lipoprotein subclasses are associated with metabolic and cardiovascular diseases, yet the genetic contributions to variability in subclass traits are not fully understood. We conducted single-variant and gene-based ...info:eu-repo/semantics/article
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Comorbid opioid use is undertreated among forensic patients with schizophrenia
(Springer Nature America, Inc, 2018)Background Substance use disorders are associated with poorer clinical outcomes in patients with schizophrenia. There is no specific treatment for amphetamine or cannabis use disorder, but methadone and buprenorphine are ...Tieteelliset aikakauslehtiartikkelit
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Comparative Effectiveness of Antipsychotic Drugs for Rehospitalization in Schizophrenia-A Nationwide Study With 20-Year Follow-up
(Oxford University Press (OUP), 2018)Very little is known about the comparative long-term effectiveness of novel antipsychotics in relapse prevention, especially in first-episode schizophrenia. Nationwide data from Finnish health care registers were gathered ...info:eu-repo/semantics/article
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Comparative molecular field analysis and molecular dynamics studies of the dopamine D2 receptor antagonists without a protonatable nitrogen atom
(Springer Nature, 2018)The dopaminergic hypothesis of schizophrenia is the main concept explaining the direct reasons of schizophrenia and the effectiveness of current antipsychotics. All antipsychotics present on the market are potent dopamine ...Tieteelliset aikakauslehtiartikkelit
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Comparison between integrated continuous direct compression line and batch processing - The effect of raw material properties
(Elsevier BV, 2019)There is a current trend in pharmaceutical manufacturing to shift from traditional batch manufacture to continuous manufacturing. The purpose of this study was to test the ability of an integrated continuous direct compression ...Tieteelliset aikakauslehtiartikkelit
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Comparison between twin-screw and high-shear granulation - The effect of filler and active pharmaceutical ingredient on the granule and tablet properties
(Elsevier BV, 2020)The aim of the study was to compare continuous twin-screw granulation (TSG) with batch-wise high-shear granulation (HSG). Two different formulations containing either microcrystalline cellulose (MCC) and mannitol or MCC ...Tieteelliset aikakauslehtiartikkelit
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Comparison of Communication Channels for Large-Scale Type 2 Diabetes Risk Screening and Intervention Recruitment: Empirical Study
(JMIR Publications Inc., 2021)Background: Clinical trials have shown that type 2 diabetes (T2D) is preventable through lifestyle interventions targeting high-risk people. Nevertheless, large-scale implementation of risk identification followed by ...Tieteelliset aikakauslehtiartikkelit
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Comparison of Diagnostic Performance of Semi-Quantitative Knee Ultrasound and Knee Radiography with MRI: Oulu Knee Osteoarthritis Study
(Springer Nature, 2016)Osteoarthritis (OA) is a common degenerative musculoskeletal disease highly prevalent in aging societies worldwide. Traditionally, knee OA is diagnosed using conventional radiography. However, structural changes of articular ...info:eu-repo/semantics/article
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Comparison of efficiency and function of VEGF adenovirus vectors in endothelial cells for gene therapy of placental insufficiency
(Mary Ann Liebert Inc, 2020)Severe fetal growth restriction (FGR) affects 1:500 pregnancies, is untreatable and causes serious neonatal morbidity and death. Reduced uterine blood flow (UBF) and lack of bioavailable VEGF due to placental insufficiency ...Tieteelliset aikakauslehtiartikkelit
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Comparison of Expert Opinion, Majority Rule, and a Clinical Prediction Rule to Estimate Distal Radius Malalignment
(Ovid Technologies (Wolters Kluwer Health), 2017)Objectives: To investigate the ability of individual surgeons (expert opinion [EO]) to predict distal radius fracture healing above a threshold malalignment compared with the majority prediction of the group of surgeons ...info:eu-repo/semantics/article
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Comparison of feature representations in MRI-based MCI-to-AD conversion prediction
(Elsevier BV, 2018)Alzheimer's disease (AD) is a progressive neurological disorder in which the death of brain cells causes memory loss and cognitive decline. The identification of at-risk subjects yet showing no dementia symptoms but who ...Tieteelliset aikakauslehtiartikkelit
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Comparison of mannitol and citric acid cough provocation tests
(Elsevier BV, 2019)Rationale Citric acid has been used as a cough provocation test for decades. However, the methods of administration have not been standardized. Inhaled mannitol is a novel cough provocation test, which has regulatory ...Tieteelliset aikakauslehtiartikkelit
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Competence areas of health science teachers - a systematic review of quantitative studies
(Elsevier BV, 2018)Background In the face of rapid digitalisation and ever-higher educational requirements for healthcare professionals, it is important that health science teachers possess the relevant core competences. The education of ...Tieteelliset aikakauslehtiartikkelit
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Competence Transformation in Healthcare Contexts: A Concept Analysis
(International Journal of Caring Sciences, 2021)Aim: This study aims to understand what competence transformation is in healthcare contexts and to develop an operational framework of the concept. Background: Globally, healthcare systems are unsustainable. Stakeholders ...Tieteelliset aikakauslehtiartikkelit
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Complete androgen insensitivity syndrome caused by a deep intronic pseudoexon-activating mutation in the androgen receptor gene
(Nature Publishing Group, 2016)Mutations in the X-linked androgen receptor (AR) gene underlie complete androgen insensitivity syndrome (CAIS), the most common cause of 46,XY sex reversal. Molecular genetic diagnosis of CAIS, however, remains uncertain ...info:eu-repo/semantics/article
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Components of the Magnet® model provide structure for the future vision of nurse managers' work: A qualitative perspective of nurse managers
(Wiley, 2021)Aim To describe nurse managers’ views of their work in the future. Background Ongoing reformation of health care organisations includes profound changes to nurse managers’ work practices. Method A qualitative ...Tieteelliset aikakauslehtiartikkelit
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Comprehensive evaluation of coding region point mutations in microsatellite-unstable colorectal cancer
(EMBO, 2018)Microsatellite instability (MSI) leads to accumulation of an excessive number of mutations in the genome, mostly small insertions and deletions. MSI colorectal cancers (CRCs), however, also contain more point mutations ...Tieteelliset aikakauslehtiartikkelit
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Comprehensive Ocular and Systemic Pharmacokinetics of Brinzolamide in Rabbits After Intracameral, Topical, and Intravenous Administration
(Elsevier BV, 2021)Brinzolamide is a topical carbonic anhydrase inhibitor which reduces the production of aqueous humor in the ciliary body, thereby reducing intra-ocular pressure. It is formulated as an ophthalmic suspension. The pharmacokinetics ...Tieteelliset aikakauslehtiartikkelit
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Comprehensive pharmacogenomic study reveals an important role of UGT1A3 in montelukast pharmacokinetics
(Wiley-Blackwell, 2017)To identify the genetic basis of interindividual variability in montelukast exposure, we determined its pharmacokinetics and sequenced 379 pharmacokinetic genes in 191 healthy volunteers. An intronic single nucleotide ...info:eu-repo/semantics/article