Browsing Terveystieteiden tiedekunta by Title
Now showing items 348-367 of 1735
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Conserved salt bridges facilitate assembly of the helical core export apparatus of a Salmonella enterica type III secretion system
(Elsevier BV, 2021)Virulence-associated type III secretion systems (T3SS) are utilized by Gram negative bacterial pathogens for injection of effector proteins into eukaryotic host cells. The transmembrane export apparatus at the core of T3SS ...Tieteelliset aikakauslehtiartikkelit
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Consortium genome-wide meta-analysis for childhood dental caries traits
(Oxford University Press (OUP), 2018)Prior studies suggest dental caries traits in children and adolescents are partially heritable, but there has been no large-scale consortium genome-wide association study (GWAS) to date. We therefore performed GWAS for ...Tieteelliset aikakauslehtiartikkelit
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Construct Validity of Clinical Nurse Specialist Core Competency Scale: An Exploratory Factor Analysis
(Wiley, 2020)Aim To conduct a construct validity test on a clinical nurse specialist core competency scale. Background Clinical nurse specialists’ competency development dates back to the late 20th century; however, there is ...Tieteelliset aikakauslehtiartikkelit
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Constructing content validity of clinical nurse specialist core competencies: exploratory sequential mixed-method study
(Wiley, 2018)Rational The demand to increase nursing competence is brought on by the requirement of safe, accessible and more effective use of healthcare provider expertise. Clinical nurse specialist competency development dates back ...Tieteelliset aikakauslehtiartikkelit
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Contacting co-culture of human retinal microvascular endothelial cells alters barrier function of human embryonic stem cell derived retinal pigment epithelial cells
(Elsevier BV, 2017)Here we evaluated the effects of human retinal microvascular endothelial cells (hREC) on mature human embryonic stem cell (hESC) derived retinal pigment epithelial (RPE) cells. The hESC-RPE cells (Regea08/017, Regea08/023 ...info:eu-repo/semantics/article
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Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants
(Oxford University Press (OUP), 2018)Background Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) ...Tieteelliset aikakauslehtiartikkelit
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Controlling of N-Alkylpolyamine Analogue Metabolism by Selective Deuteration
(Portland Press Ltd., 2018)Replacing protium with deuterium is an efficient method to modulate drug metabolism. N-alkylated polyamine analogues are polyamine antimetabolites with proven anticancer efficacy. We have characterized earlier the preferred ...Tieteelliset aikakauslehtiartikkelit
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Controlling the regioselectivity and stereospecificity of FAD-dependent polyamine oxidases with the use of amine-attached guide molecules as conformational modulators
(Portland Press Ltd., 2018)Enzymes generally display strict stereospecificity and regioselectivity for their substrates. Here by using FAD-dependent human acetylpolyamine oxidase (APAO), human spermine (Spm) oxidase (SMOX) and yeast polyamine oxidase ...Tieteelliset aikakauslehtiartikkelit
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Converting a batch based high-shear granulation process to a continuous dry granulation process; a demonstration with ketoprofen tablets
(Elsevier BV, 2020)When one wishes to convert a batch based manufacturing process of an existing tablet product to a continuous process, there are several available strategies which can be adopted. Theoretically, the most straightforward way ...Tieteelliset aikakauslehtiartikkelit
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Copy number loss in SFMBT1 is common among Finnish and Norwegian patients with iNPH
(Ovid Technologies (Wolters Kluwer Health), 2018)Objective To evaluate the role of the copy number loss in SFMBT1 in a Caucasian population. Methods Five hundred sixty-seven Finnish and 377 Norwegian patients with idiopathic normal pressure hydrocephalus (iNPH) ...Tieteelliset aikakauslehtiartikkelit
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Core competencies of clinical nurse specialists: A comparison across three Nordic countries
(Wiley, 2021)Aim To describe and compare the clinical nurse specialist core competency use in Finland, Denmark and Iceland. Background Clinical nurse specialist roles were first developed more than 60 years ago in the United States. ...Tieteelliset aikakauslehtiartikkelit
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Corneal and conjunctival drug permeability : systematic comparison and pharmacokinetic impact in the eye
(Elsevier BV, 2018)On the surface of the eye, both the cornea and conjunctiva are restricting ocular absorption of topically applied drugs, but barrier contributions of these two membranes have not been systemically compared. Herein, we ...Tieteelliset aikakauslehtiartikkelit
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Coronary heart disease incidence and mortality, and all-cause mortality among diabetic and non-diabetic people according to their smoking behavior in Finland
(Springer Nature, 2017)Background As type 2 diabetes (T2D) patients have a high risk for coronary heart disease (CHD) and all-cause mortality and smoking is a major single risk factor for total and CHD mortality, it is important to understand ...info:eu-repo/semantics/article
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Coronary heart disease risk factor levels in eastern and western Finland from 1980 to 2011 in the cardiovascular risk in Young Finns study
(Elsevier BV, 2018)Background and aims In the 1960s and 1970s, Finland, mortality due to coronary heart disease (CHD) was over 30% higher among Finns residing in the east of the country compared with those residing in the west. Today, CHD ...Tieteelliset aikakauslehtiartikkelit
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Coronary Revascularization and Postoperative Outcomes in People With and Without Alzheimer's Disease
(Oxford University Press (OUP), 2021)Background Little is known on the incidence and postoperative outcomes of revascularizations according to electivity in persons with Alzheimer’s disease (AD). Methods The Medication Use and Alzheimer’s disease (MEDALZ) ...Tieteelliset aikakauslehtiartikkelit
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Correct expression and localization of collagen xiii is crucial for the normal formation and function of the neuromuscular system
(Wiley, 2019)Transmembrane collagen XIII has been linked to maturation of the musculoskeletal system. Its absence in mice (Col13a1−/−) results in impaired neuromuscular junction (NMJ) differentiation and function, while transgenic ...Tieteelliset aikakauslehtiartikkelit
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Correlation between calculated molecular descriptors of excipient amino acids and experimentally observed thermal stability of lysozyme
(, 2017)A quantitative structure-property relationship (QSPR) between protein stability and the physicochemical properties of excipients was investigated to enable a more rational choice of stabilizing excipients than prior ...info:eu-repo/semantics/article
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Correlative Light and Electron Microscopy Reveals the HAS3-Induced Dorsal Plasma Membrane Ruffles
(Hindawi Publishing Corporation, 2015)Hyaluronan is a linear sugar polymer synthesized by three isoforms of hyaluronan synthases (HAS1, 2, and 3) that forms a hydrated scaffold around cells and is an essential component of the extracellular matrix. The ...info:eu-repo/semantics/article
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Cortical and subcortical T1 white/gray contrast, chronological age, and cognitive performance
(Elsevier BV, 2019)The maturational schedule of typical brain development is tightly constrained; deviations from it are associated with cognitive atypicalities, and are potentially predictive of developmental disorders. Previously, we have ...Tieteelliset aikakauslehtiartikkelit
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Cost-effectiveness analysis for a tele-based health coaching program for chronic disease in primary care
(Springer Nature, 2017)Background The burden of chronic disease and multimorbidity is rapidly increasing. Self-management support interventions are effective in reduce cost, especially when targeted at a single disease group; however, economical ...info:eu-repo/semantics/article