Browsing Terveystieteiden tiedekunta by Title

Now showing items 413-432 of 1735

    • Depletion of the Third Complement Component Ameliorates Age-Dependent Oxidative Stress and Positively Modulates Autophagic Activity in Aged Retinas in a Mouse Model 

      Roginska Dorota; Kawa Milosz P; Pius-Sadowska Ewa; Lejkowska Renata; Luczkowska Karolina; Wiszniewska Barbara; Kaarniranta Kai; Paterno Jussi J; Schmidt Christian A; Machalinski Boguslaw; Machalinska Anna (Hindawi Limited, 2017)
      The aim of the study was to investigate the influence of complement component C3 global depletion on the biological structure and function of the aged retina. In vivo morphology (OCT), electrophysiological function (ERG), ...
      info:eu-repo/semantics/article

    • Depression is associated with the long-term outcome of lumbar spinal stenosis surgery: a 10-year follow-up study 

      Tuomainen, I; Pakarinen, M; Aalto, T; Sinikallio, S; Kröger, H; Viinamäki, H; Airaksinen, O (Elsevier BV, 2018)
      Background Context Depression is associated with greater postoperative disability in patients with lumbar spinal stenosis (LSS). No previous studies have reported the association in a 10-year follow-up. Purpose To ...
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    • Deregulation of the non-coding genome in leukemia 

      Teppo Susanna; Heinäniemi Merja; Lohi Olli (Informa UK Limited, 2017)
      Methodological advances that allow deeper characterization of non-coding elements in the genome have started to reveal the full spectrum of deregulation in cancer. We generated an inducible cell model to track transcriptional ...
      info:eu-repo/semantics/article

    • Design and synthesis of lipid-mimetic cationic iridium complexes and their liposomal formulation for in vitro and in vivo application in luminescent bioimaging 

      Shakirova, Julia R; Sadeghi, Amir; Koblova, Alla A; Chelushkin, Pavel S; Toropainen, Elisa; Tavakoli, Shirin; Kontturi, Leena-Stiina; Lajunen, Tatu; Tunik, Sergey P; Urtti, Arto (Royal Society of Chemistry (RSC), 2020)
      Two iridium [Ir(N^C)2(N^N)]+ complexes with the diimine N^N ligand containing a long polymethylene hydrophobic chain were synthesized and characterized by using NMR and ESI mass-spectrometry: N^N – 2-(1-hexadecyl-1H-imid ...
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    • Design and synthesis of novel fluorescently labeled analogs of vemurafenib targeting MKK4 

      Kircher, Theresa; Pantsar, Tatu; Oder, Andreas; Peter von Kries, Jens; Juchum, Michael; Pfaffenrot, Bent; Kloevekorn, Philip; Albrecht, Wolfgang; Selig, Roland; Laufer, Stefan (Elsevier BV, 2021)
      The mitogen-activated protein kinase kinase 4 (MKK4) plays a key role in liver regeneration and is under investigation as a target for stimulating hepatocytes to increased proliferation. Therefore, new small molecules ...
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    • Design, Synthesis and Biological Activity of Novel Substituted 3-benzoic Acid Derivatives as MtDHFR Inhibitors 

      Kronenberger, Thales; Ferreira, Glaucio Monteiro; de Souza, Alfredo Danilo Ferreira; da Silva Santos, Soraya; Poso, Antti; Ribeiro, João Augusto; Tavares, Maurício Temotheo; Pavan, Fernando Rogério; Trossini, Gustavo Henrique Goulart; Dias, Marcio Vinícius Bertacine; Parise-Filho, Roberto (Elsevier BV, 2020)
      The enzyme dihydrofolate reductase from M. tuberculosis (MtDHFR) has a high unexploited potential to be a target for new drugs against tuberculosis (TB), due to its importance for pathogen survival. Preliminary studies ...
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    • Design, synthesis and biological evaluation of antiparasitic dinitroaniline-ether phospholipid hybrids 

      Roussaki, Marina; Magoulas, George E; Fotopoulou, Theano; Santarem, Nuno; Barrias, Emile; Pöhner, Ina; Luelmo, Sara; Afroudakis, Pantelis; Georgikopoulou, Kalliopi; Tejera Nevado, Paloma; Eick, Julia; Bifeld, Eugenia; Corral, María J; Dolores Jiménez-Antón, María; Ellinger, Bernhard; Kuzikov, Maria; Fragiadaki, Irini; Scoulica, Effie; Gul, Sheraz; et al (Elsevier Inc, 2023)
      A series of nine novel ether phospholipid-dinitroaniline hybrids were synthesized in an effort to deliver more potent antiparasitic agents with improved safety profile compared to miltefosine. The compounds were evaluated ...

    • Design, Synthesis, and Biological Evaluation of 2,4-Dihydropyrano[2,3-c]pyrazole Derivatives as Autotaxin Inhibitors 

      Pantsar T; Singha P; Nevalainen TJ; Koshevoy I; Leppänen J; Poso A; Niskanen JMA; Pasonen-Seppänen S; Savinainen JR; Laitinen T; Laitinen JT (Elsevier BV, 2017)
      Inhibition of Autotaxin (ATX) is a potential treatment strategy for several diseases, including tumors with elevated ATX-lysophosphatidic acid (LPA) signaling. Combining structure-based virtual screening together with hen ...
      info:eu-repo/semantics/article

    • Detection of Hyperexcitability by fMRI After Experimental Traumatic Brain Injury 

      Huttunen, JK; Airaksinen, AM; Barba, C; Colicchio, G; Niskanen, JP; Shatillo, A; Sierra Lopez, A; Ndode-Ekane, XE; Pitkanen, A; Gröhn, O (Mary Ann Liebert Inc, 2018)
      Diagnosis of ongoing epileptogenesis and associated hyperexcitability after brain injury is a major challenge. Given that increased neuronal activity in the brain triggers a blood oxygenation level–dependent (BOLD) response ...
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    • Detection of lentiviral suicide gene therapy in C6 rat glioma using hyperpolarised [1-13 C]pyruvate 

      Nivajärvi, R; Olsson, V; Hyppönen, V; Bowen, S; Leinonen, HM; Lesch, HP; Ardenkjaer-Larsen, JH; Gröhn, OHJ; Ylä-Herttuala, S; Kettunen, MI (Wiley, 2020)
      Hyperpolarised [1‐13C]pyruvate MRI has shown promise in monitoring therapeutic efficacy in a number of cancers including glioma. In this study, we assessed the pyruvate response to the lentiviral suicide gene therapy of ...
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    • Detection of medications associated with Alzheimer's disease using ensemble methods and cooperative game theory 

      Braithwaite, B; Paananen, J; Taipale, H; Tanskanen, A; Tiihonen, J; Hartikainen, S; Tolppanen, A-M (Elsevier BV, 2020)
      Objective To study the feasibility of evaluating feature importance with Shapley Values and ensemble methods in the context of pharmacoepidemiology and medication safety. Methods We detected medications associated ...
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    • Determinants of hospitalizations for pneumonia among Finnish drug users 

      Olubamwo, OO; Onyeka, IN; Aregbesola, A; Ronkainen, K; Tiihonen, J; Föhr, J; Kauhanen, J (SAGE Publications, 2018)
      Objective: The study examined the determinants of being hospitalized for pneumonia in a large cohort of drug users. Methods: Information of 4817 clients seeking treatment for illicit drug use was linked with the Finnish ...
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    • Determinants of pain and functioning in knee osteoarthritis: a one-year prospective study 

      Helminen EE; Sinikallio SH; Valjakka AL; Väisänen-Rouvali RH; Arokoski JP (Sage Publications Ltd, 2016)
      Objective: To identify predictors of pain and disability in knee osteoarthritis. Design: A one-year prospective analysis of determinants of pain and functioning in knee osteoarthritis. Study setting: Primary care ...
      info:eu-repo/semantics/article

    • Determination of Residence Time Distribution in a Continuous Powder Mixing Process With Supervised and Unsupervised Modeling of In-line Near Infrared (NIR) Spectroscopic Data 

      Pedersena, Troels; Karttunen, Anssi-Pekka; Korhonen, Ossi; Wu, Jian Xiong; Naelapää, Kaisa; Skibsted, Erik; Rantanen, Jukka (Elsevier BV, 2021)
      Successful implementation of continuous manufacturing processes requires robust methods to assess and control product quality in a real-time mode. In this study, the residence time distribution of a continuous powder mixing ...
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    • Development and implementation of a geographical area categorisation method with targeted performance indicators for nationwide EMS in Finland 

      Pappinen J; Laukkanen-Nevala P; Mäntyselkä P; Kurola J. (Springer Nature, 2018)
      Background In Finland, hospital districts (HD) are required by law to determine the level and availability of Emergency Medical Services (EMS) for each 1-km2 sized area (cell) within their administrative area. The cells ...
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    • Development and Psychometric Testing of the Registered Nurses' Perceptions of Rewarding Scale 

      Seitovirta, Jaana; Lehtimäki, Aku-Ville; Vehviläinen-Julkunen, Katri; Mitronen, Lasse; Kvist, Tarja (Ovid Technologies (Wolters Kluwer Health), 2018)
      Background: Rewarding is a powerful way to recognize, manage, and retain staff. However, the perceptions of registered nurses (RNs) toward rewarding have not yet been extensively examined in nursing studies. It is important ...
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    • Development and testing of an instrument (HeSoEduCo) for health and social care educators' competence in professional education 

      Mikkonen, Kristina; Tuomikoski, Anna-Maria; Sjögren, Tuulikki; Koivula, Meeri; Koskimäki, Minna; Lähteenmäki, Marja-Leena; Mäki-Hakola, Hanne; Wallin, Outi; Sormunen, Marjorita; Saaranen, Terhi; Koskinen, Camilla; Koskinen, Monika; Salminen, Leena; Holopainen, Arja; Kääriäinen, Maria (Elsevier BV, 2020)
      Background Health and social care education is highly important for preparing future professionals for their future roles in sustainable health and social care. However, previous studies have emphasized that health and ...
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    • Development of a fermented quinoa-based beverage 

      Ludena Urquizo Fanny Emma; García Torres Silvia Melissa; Tolonen Tiina; Jaakkola Mari; Grazzia Pena-Niebuhr Maria; von Wright Atte; Repo-Carrasco-Valencia Ritva; Korhonen Hannu; Plumed-Ferrer Carme (Wiley-Blackwell, 2016)
      Quinoa is a crop that originated from the Andes. It has high nutritional value, outstanding agro-ecological adaptability, and low water requirements. Quinoa is an excellent crop alternative to help overcome food shortages, ...
      info:eu-repo/semantics/article

    • Development of an Image-Guided Orthotopic Xenograft Mouse Model of Endometrial Cancer with Controllable Estrogen Exposure 

      Konings, GF; Saarinen, N; Delvoux, B; Kooreman, L; Koskimies, P; Krakstad, C; Fasmer, KE; Haldorsen, IS; Zaffagnini, A; Häkkinen, MR; Auriola, S; Dubois, L; Lieuwes, N; Verhaegen, F; Schyns, LE; Kruitwagen, RF; Xanthoulea, S; Romano, A (MDPI AG, 2018)
      Endometrial cancer (EC) is the most common gynaecological malignancy in Western society and the majority of cases are estrogen dependent. While endocrine drugs proved to be of insufficient therapeutic value in the past, ...
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    • Development of an International Tool for Students to Record and Reflect on Patient Safety Learning Experiences 

      Steven, Alison; Pearson, Pauline; Turunen, Hannele; Myhre, Kristin; Sasso, Loredana; Vizcaya-Moreno, Maria Flores; Pérez-Cañaveras, Rosa María; Sara-Aho, Arja; Bagnasco, Annamaria; Aleo, Giuseppe; Patterson, Lucy; Larkin, Valerie; Zanini, Milko; Porras, Jari; Khakurel, Jayden; Azimirad, Mina; Ringstad, Øystein; Johnsen, Lasse; Haatainen, Kaisa; Wilson, Gemma; Rossi, Silvia; Morey, Sarah; Tella, Susanna (Ovid Technologies (Wolters Kluwer Health), 2021)
      Background: Underpinning all nursing education is the development of safe practitioners who provide quality care. Learning in practice settings is important, but student experiences vary. Purpose: This study aimed ...
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