Browsing Terveystieteiden tiedekunta by Title
Now showing items 446-465 of 1735
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Difference in Rupture Risk Between Familial and Sporadic Intracranial Aneurysms: An Individual Patient Data Meta-analysis
(Ovid Technologies (Wolters Kluwer Health), 2021)Background and Objectives We combined individual patient data (IPD) from prospective cohorts of patients with unruptured intracranial aneurysms (UIAs) to assess to what extent patients with familial UIA have a higher rupture ...Tieteelliset aikakauslehtiartikkelit
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Difference in the core-shell dynamics of polyethyleneimine and poly(L-lysine) DNA polyplexes
(, 2017)Electrostatic polymer-DNA complexes (polyplexes) have been widely investigated for DNA delivery, and remarkable differences in transfection efficacy have been seen among the materials. For example, polyethyleneimine (PEI) ...info:eu-repo/semantics/article
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Different Trajectories of Depressive Symptoms in Alzheimer’s Disease Caregivers – 5-Year Follow-Up
(Taylor & Francis Group, LLC, 2022)Objectives The care of individuals with Alzheimer’s disease (AD) relies on family caregivers (FCs) who face increasing demands. This study aimed to identify trajectories of depressive symptoms in FCs. Methods 226 FCs ...
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Differential but Complementary HIF1[alfa] and HIF2[alfa] Transcriptional Regulation
(Elsevier BV, 2018)Effective vascular regeneration could provide therapeutic benefit for multiple pathologies, especially in chronic peripheral artery disease (PAD) and myocardial ischemia. The hypoxia inducible factors (HIFs) mediate the ...Tieteelliset aikakauslehtiartikkelit
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Differential diagnosis of neurodegenerative diseases using structural MRI data
(Elsevier, 2016)Different neurodegenerative diseases can cause memory disorders and other cognitive impairments. The early detection and the stratification of patients according to the underlying disease are essential for an efficient ...info:eu-repo/semantics/article
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Differential effects of the Piezo1 agonist Yoda1 in the trigeminovascular system: An electrophysiological and intravital microscopy study in rats
(Elsevier BV, 2021)Migraine is associated with the activation and sensitisation of the trigeminovascular system and is often accompanied by mechanical hyperalgesia and allodynia. The mechanisms of mechanotransduction during a migraine attack ...Tieteelliset aikakauslehtiartikkelit
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Differentially cleaving peptides as a strategy for controlled drug release in human retinal pigment epithelial cells
(Elsevier BV, 2017)Currently, drug delivery to the posterior eye segment relies on intravitreal injections of therapeutics. This approach requires frequent injections and does not guarantee drug delivery to intracellular targets. Controlled ...info:eu-repo/semantics/article
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Digital Versus Conventional Impressions in Fixed Prosthodontics: A Review
(Wiley-Blackwell, 2018)Purpose To conduct a systematic review to evaluate the evidence of possible benefits and accuracy of digital impression techniques vs. conventional impression techniques. Materials and Methods Reports of digital ...Tieteelliset aikakauslehtiartikkelit
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Direct bacterioscopic observation of Helicobacter in the oral cavity, stomach and rectum
(Scitechnol Biosoft Pvt. Ltd., 2018)Background Bacterial cells of Helicobacter Pylori (HP) are often found in people with chronic gastritis and peptic ulcer disease (PUD). All patients with symptoms are usually screened for HP bacterial cells by different ...Tieteelliset aikakauslehtiartikkelit
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Discovery of 12-Thiazole Abietanes as Selective Inhibitors of the Human Metabolic Serine Hydrolase hABHD16A
(, 2018)Screening of an in-house library of compounds identified 12-thiazole abietanes as a new class of reversible inhibitors of the human metabolic serine hydrolase. Further optimization of the first hit compound lead to the ...Tieteelliset aikakauslehtiartikkelit
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Discovery of novel arylpiperazine-based DA/5-HT modulators as potential antipsychotic agents – Design, synthesis, structural studies and pharmacological profiling
(Elsevier Masson SAS, 2023)Schizophrenia is a mental disorder with a complex pathomechanism involving many neurotransmitter systems. Among the currently used antipsychotics, classical drugs acting as dopamine D2 receptor antagonists, and drugs of a ...
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Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies
(Nature Publishing Group, 2015)Activation of androgen receptor (AR) is crucial for prostate cancer growth. Remarkably, also castration-resistant prostate cancer (CRPC) is dependent on functional AR, and several mechanisms have been proposed to explain ...info:eu-repo/semantics/article
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Discovery of Polar Spirocyclic Orally Bioavailable Urea Inhibitors of Soluble Epoxide Hydrolase
(Elsevier BV, 2018)Spirocyclic 1-oxa-9-azaspiro[5.5]undecan-4-amine scaffold was explored as a basis for the design of potential inhibitors of soluble epoxide hydrolase (sEH). Synthesis and testing of the initial SAR-probing library followed ...Tieteelliset aikakauslehtiartikkelit
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Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
(Springer Science and Business Media LLC, 2020)Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to ~1.3 million participants, we discovered 106 new BP-associated genomic regions ...Tieteelliset aikakauslehtiartikkelit
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Disease severity classification using quantitative magnetic resonance imaging data of cartilage in femoroacetabular impingement
(2017)Femoroacetabular impingement (FAI) is a condition in which subtle deformities of the femoral head and acetabulum (hip socket) result in pathological abutment during hip motion. FAI is a common cause of hip pain and can ...info:eu-repo/semantics/article
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Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy
(Elsevier BV, 2017)Treatment of TBI remains a major unmet medical need, with 2.5 million new cases of traumatic brain injury (TBI) each year in Europe and 1.5 million in the USA. This single-center proof-of-concept preclinical study tested ...info:eu-repo/semantics/article
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Dislocation of large-diameter head metal-on-metal total hip arthroplasty and hip resurfacing arthroplasty
(SAGE Publications, 2018)Introduction: Dislocation of large-diameter head (LDH) metal-on-metal (MoM) total hip arthroplasty (THA) or hip resurfacing arthroplasty (HRA) is a rare complication. This study aimed to determine the incidence and risk ...Tieteelliset aikakauslehtiartikkelit
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Disparities in cervical screening participation: a comparison of Russian, Somali and Kurdish immigrants with the general Finnish population
(Springer Nature, 2018)Background Cervical cancer is currently ranked as the fourth commonly diagnosed cancer in women globally. A higher incidence has been reported in low- and-middle-income countries, and the disease poses significant public ...Tieteelliset aikakauslehtiartikkelit
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Disrupted network topology in patients with stable and progressive mild cognitive impairment and Alzheimer's disease
(Oxford University Press, 2016)Recent findings suggest that Alzheimer's disease (AD) is a disconnection syndrome characterized by abnormalities in large-scale networks. However, the alterations that occur in network topology during the prodromal stages ...info:eu-repo/semantics/article
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Dissolution and permeability properties of co-amorphous formulations of hydrochlorothiazide
(Elsevier BV, 2020)A biopharmaceutics classification system class IV drug, hydrochlorothiazide (HCT), was combined with co-formers of L-and d-arginine (ARG) and sodium lauryl sulphate (SLS) by cryomilling in 1:1 molar ratio. Co-amorphization ...Tieteelliset aikakauslehtiartikkelit