Browsing Terveystieteiden tiedekunta by Title
Now showing items 459-478 of 1735
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Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
(Springer Science and Business Media LLC, 2020)Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to ~1.3 million participants, we discovered 106 new BP-associated genomic regions ...Tieteelliset aikakauslehtiartikkelit
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Disease severity classification using quantitative magnetic resonance imaging data of cartilage in femoroacetabular impingement
(2017)Femoroacetabular impingement (FAI) is a condition in which subtle deformities of the femoral head and acetabulum (hip socket) result in pathological abutment during hip motion. FAI is a common cause of hip pain and can ...info:eu-repo/semantics/article
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Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy
(Elsevier BV, 2017)Treatment of TBI remains a major unmet medical need, with 2.5 million new cases of traumatic brain injury (TBI) each year in Europe and 1.5 million in the USA. This single-center proof-of-concept preclinical study tested ...info:eu-repo/semantics/article
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Dislocation of large-diameter head metal-on-metal total hip arthroplasty and hip resurfacing arthroplasty
(SAGE Publications, 2018)Introduction: Dislocation of large-diameter head (LDH) metal-on-metal (MoM) total hip arthroplasty (THA) or hip resurfacing arthroplasty (HRA) is a rare complication. This study aimed to determine the incidence and risk ...Tieteelliset aikakauslehtiartikkelit
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Disparities in cervical screening participation: a comparison of Russian, Somali and Kurdish immigrants with the general Finnish population
(Springer Nature, 2018)Background Cervical cancer is currently ranked as the fourth commonly diagnosed cancer in women globally. A higher incidence has been reported in low- and-middle-income countries, and the disease poses significant public ...Tieteelliset aikakauslehtiartikkelit
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Disrupted network topology in patients with stable and progressive mild cognitive impairment and Alzheimer's disease
(Oxford University Press, 2016)Recent findings suggest that Alzheimer's disease (AD) is a disconnection syndrome characterized by abnormalities in large-scale networks. However, the alterations that occur in network topology during the prodromal stages ...info:eu-repo/semantics/article
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Dissolution and permeability properties of co-amorphous formulations of hydrochlorothiazide
(Elsevier BV, 2020)A biopharmaceutics classification system class IV drug, hydrochlorothiazide (HCT), was combined with co-formers of L-and d-arginine (ARG) and sodium lauryl sulphate (SLS) by cryomilling in 1:1 molar ratio. Co-amorphization ...Tieteelliset aikakauslehtiartikkelit
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Dissolution behavior of co-amorphous amino acid-indomethacin mixtures: The ability of amino acids to stabilize the supersaturated state of indomethacin
(Elsevier BV, 2016)Arginine, phenylalanine, and tryptophan have been previously shown to improve the solid-state stability of amorphous indomethacin. The present study investigates the ability of these amino acids to prolong the supersaturation ...info:eu-repo/semantics/article
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Distinct age-related patterns of overweight development to guide school health care interventions
(Wiley, 2020)Aim We aimed to identify groups of primary school children with similar overweight development, reveal age‐related patterns of overweight development in the resulting groups and analyse overweight‐related school healthcare ...Tieteelliset aikakauslehtiartikkelit
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Distinct Characteristics of Rye and Wheat Breads Impact on Their in Vitro Gastric Disintegration and in Vivo Glucose and Insulin Responses
(MDPI AG, 2016)Disintegration of rye and wheat breads during in vitro gastric digestion and its relation to the postprandial glucose and insulin responses of the breads was studied. Breads with distinct composition and texture characteristics ...info:eu-repo/semantics/article
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Diurnal cortisol, neuroinflammation, and neuroimaging visual rating scales in memory clinic patients
(Elsevier Inc, 2024)Background Neuroinflammation is a hallmark of the Alzheimer’s disease (AD) pathogenic process. Cortisol dysregulation may increase AD risk and is related to brain atrophy. This cross-sectional study aims to examine ...
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Docosahexaenoic acid,22:6n-3: its roles in the structure and function of the brain
(Elsevier BV, 2019)Docosahexaenoic acid,22:6n-3 (DHA) and its metabolites are vital for the structure and functional brain development of the fetus and infants, and also for maintenance of healthy brain function of adults. DHA is thought to ...Tieteelliset aikakauslehtiartikkelit
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Does Fruit and Vegetable Consumption During Adolescence Predict Adult Depression? A Longitudinal Study of US Adolescents
(Frontiers Media SA, 2018)The relationship between better diet quality and decreased depression across the life span is consistent and compelling. Fruit and vegetable consumption has been of particular interest. The nutritional benefits from the ...Tieteelliset aikakauslehtiartikkelit
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Does Future Diabetes Risk Impair Current Quality of Life? A Cross-Sectional Study of Health-Related Quality of Life in Relation to the Finnish Diabetes Risk Score (FINDRISC)
(Public Library of Science, 2016)Objectives Present study examines the relationship between the estimated risk of developing type 2 diabetes (T2D) and health-related quality of life (HRQoL). We quantify the association between Finnish Diabetes Risk Score ...info:eu-repo/semantics/article
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Does Implementation Follow Design? A Case Study of a Workplace Health Promotion Program Using the 4-S Program Design and the PIPE Impact Metric Evaluation Models
(Wiley-Blackwell, 2017)Objective: The aim of this study was to describe the content of a multiyear market-based workplace health promotion (WHP) program and to evaluate design and implementation processes in a real-world setting. Methods: ...info:eu-repo/semantics/article
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Does routinely collected patient-reported outcome data represent the actual case-mix of elective coronary revascularization patients?
(Oxford University Press (OUP), 2017)Aims Patient-reported outcomes (PROs) are valuable for effectiveness evaluation, but it is unknown whether the patient views obtained represent the actual case mix. We studied the representativeness of the responses ...info:eu-repo/semantics/article
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Domesticated animal biobanking: land of opportunity
(Public Library of Science (PLoS), 2016)In the past decade, biobanking has fuelled great scientific advances in the human medical sector. Well-established domesticated animal biobanks and integrated networks likewise harbour immense potential for great scientific ...info:eu-repo/semantics/article
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Downregulation of VEGFR3 signaling alters cardiac lymphatic vessel organization and leads to a higher mortality after acute myocardial infarction
(Springer Nature America, Inc, 2018)Heart has a wide lymphatic network but the importance of cardiac lymphatic system in heart diseases has remained unclear. Vascular Endothelial Growth Factor Receptor 3 (VEGFR3) is a key molecule in the development and ...Tieteelliset aikakauslehtiartikkelit
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Doxycycline modulates VEGF-A expression: Failure of doxycycline-inducible lentivirus shRNA vector to knockdown VEGF-A expression in transgenic mice
(Public Library of Science (PLoS), 2018)Vascular endothelial growth factor-A (VEGF-A) is the master regulator of angiogenesis, vascular permeability and growth. However, its role in mature blood vessels is still not well understood. To better understand the role ...Tieteelliset aikakauslehtiartikkelit
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Drug exposure in register-based research - An expert-opinion based evaluation of methods
(Public Library of Science (PLoS), 2017)Background In register-based pharmacoepidemiological studies, construction of drug exposure periods from drug purchases is a major methodological challenge. Various methods have been applied but their validity is rarely ...info:eu-repo/semantics/article