Browsing Terveystieteiden tiedekunta by Title
Now showing items 513-532 of 1735
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Effects of dipeptidyl peptidase 4 inhibition on inflammation in atherosclerosis: A 18F-fluorodeoxyglucose study of a mouse model of atherosclerosis and type 2 diabetes
(Elsevier BV, 2020)Background and aims Dipeptidyl peptidase 4 (DPP-4) inhibitors have anti-inflammatory and atheroprotective effects. We evaluated the effects of the DPP-4 inhibitor linagliptin on atherosclerotic plaque and hepatic inflammation ...Tieteelliset aikakauslehtiartikkelit
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Effects of ethinyl estradiol-containing oral contraception and other factors on body composition and muscle strength among young healthy females in Finland-A cross-sectional study
(Elsevier BV, 2019)Objective: The aim of this cross-sectional study was to determine the association of hormonal contraception and other life-style factors and habits affecting body composition (BC) and muscle strength. Study design: We ...Tieteelliset aikakauslehtiartikkelit
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Effects of exercise on NAFLD using non-targeted metabolomics in adipose tissue, plasma, urine, and stool
(Springer Nature, 2022)The mechanisms by which exercise benefits patients with non-alcoholic fatty liver disease (NAFLD), the most common liver disease worldwide, remain poorly understood. A non-targeted liquid chromatography-mass spectrometry ...
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Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects
(Wiley-Blackwell, 2018)Several single nucleotide variations (SNVs) affect carboxylesterase 1 (CES1) activity, but the effects of genetic variants on CES1 gene expression have not been systematically investigated. Therefore, our aim was to ...info:eu-repo/semantics/article
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Effects of individual differences, society, and culture on youth‐rated problems and strengths in 38 societies
(John Wiley & Sons Ltd, 2022)Background Clinicians increasingly serve youths from societal/cultural backgrounds different from their own. This raises questions about how to interpret what such youths report. Rescorla et al. (2019, European Child & ...
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Effects of knee flexion and extension on the tibial tuberosity-trochlear groove (TT-TG) distance in adolescents
(Springer Nature America, Inc, 2018)Background Measurement of the tibial tubercle–trochlear groove (TT–TG) distance is used to assess patellofemoral instability and rotation. Since patellofemoral instability and acute patellar dislocation are common among ...Tieteelliset aikakauslehtiartikkelit
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Effects of leisure-time and occupational physical activities on 20-year incidence of acute myocardial infarction: mediation and interaction
(Scandinavian Journal of Work, Environment and Health, 2016)Objectives: This study aimed to disentangle the interplay between occupational physical activity (OPA) and leisure-time physical activity (LTPA) in affecting cardiovascular health by examining: (i) interactions between OPA ...info:eu-repo/semantics/article
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Effects of Long-term adolescent alcohol consumption on white matter integrity and their correlations with metabolic alterations
(Elsevier BV, 2019)Alcohol-related white matter (WM) microstructural changes have not been fully elucidated in adolescents. We aimed to investigate influences of subclinical alcohol use during adolescence on WM microstructure and to characterize ...Tieteelliset aikakauslehtiartikkelit
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Effects of mutations in the post-translational modification sites on the trafficking of hyaluronan synthase 2 (HAS2)
(Elsevier BV, 2019)Vesicular trafficking of hyaluronan synthases (HAS1-3) from endoplasmic reticulum (ER) through Golgi to plasma membrane (PM), and either back to endosomes and lysosomes, or out into extracellular vesicles, is important for ...Tieteelliset aikakauslehtiartikkelit
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Effects of nifedipine and sildenafil on placental hemodynamics and gas exchange during fetal hypoxemia in a chronic sheep model
(Elsevier BV, 2020)Introduction We hypothesized that nifedipine and sildenafil would have no detrimental effects on placental hemodynamics and gas exchange under fetal hypoxemia. Methods In 33 chronically instrumented fetal sheep, ...Tieteelliset aikakauslehtiartikkelit
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Effects of PCSK9 missense variants on molecular conformation and biological activity in transfected HEK293FT cells
(Elsevier B.V., 2022)PCSK9 gain-of-function (GOF) variants increase degradation of low-density lipoprotein receptor (LDLR) and are potentially associated with Familial Hypercholesterolemia (FH). This study aimed to explore the effects of PCSK9 ...
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Effects of Resvega on Inflammasome Activation in Conjunction with Dysfunctional Intracellular Clearance in Retinal Pigment Epithelial (RPE) Cells
(MDPI AG, 2021)Age-related macular degeneration (AMD) is an eye disease in which retinal pigment epithelium (RPE) cells play a crucial role in maintaining retinal homeostasis and photoreceptors’ functionality. During disease progression, ...Tieteelliset aikakauslehtiartikkelit
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Effects of sauna bath on heart failure: A systematic review and meta-analysis
(Wiley, 2018)Background Sauna bath has potential as a lifestyle treatment modality for heart failure (HF). It is important to analyze the current evidence to help suggest paths of future study and potential for clinical application. ...Tieteelliset aikakauslehtiartikkelit
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Effects of Two-Week High-Intensity Interval Training on Cognition in Adolescents - A Randomized Controlled Pilot Study
(Walter de Gruyter GmbH, 2017)Purpose. We investigated the effects of a two-week high-intensity interval training (HIT) on cognition in adolescents. Methods. The participants were recruited from local high schools with an electronic messaging system. ...info:eu-repo/semantics/article
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Efficacy and Safety of Clinical Grade hVEGF-D [delta]N[delta]C Gene Therapy Containing Residual Replication-Competent Adenoviruses
(Mary Ann Liebert Inc, 2021)Biological bypass through induced angiogenesis by vascular endothelial growth factor D (VEGF-D) gene therapy (GT) is a new concept for the treatment of cardiac ischemia. Serotype 5 adenoviruses are used in the clinical ...Tieteelliset aikakauslehtiartikkelit
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Efficacy and safety of intravenous esmolol for cardiac protection in non-cardiac surgery. A systematic review and meta-analysis
(Informa UK Limited, 2018)Haemodynamic instability predisposes patients to cardiac complications in non-cardiac surgery. Esmolol, a short-acting cardioselective beta-adrenergic blocker might be efficient in perioperative cardiac protection, but ...Tieteelliset aikakauslehtiartikkelit
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Efficacy of stabilization splint treatment on the oral-health related quality of life - a randomized controlled one-year follow-up trial
(Wiley, 2018)The aim of this randomised controlled trial was to assess the efficacy of stabilisation splint treatment on the oral health‐related quality of life OHRQoL during a 1‐year follow‐up. Originally, the sample consisted of 80 ...Tieteelliset aikakauslehtiartikkelit
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Efficient binding of the NOS1AP C-terminus to the nNOS PDZ pocket requires the concerted action of the PDZ ligand motif, the internal ExF site and structural integrity of an independent element
(Frontiers Media SA, 2017)Neuronal nitric oxide synthase is widely regarded as an important contributor to a number of disorders of excitable tissues. Recently the adaptor protein NOS1AP has emerged as a contributor to several nNOS-linked conditions. ...info:eu-repo/semantics/article
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Efficient Nuclease-Directed Integration of Lentivirus Vectors into the Human Ribosomal DNA Locus
(Elsevier BV, 2020)Lentivirus vectors (LVs) are efficient tools for gene transfer, but the non-specific nature of transgene integration by the viral integration machinery carries an inherent risk for genotoxicity. We modified the integration ...Tieteelliset aikakauslehtiartikkelit
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Efficient production of solid dispersions by spray drying solutions of high solid content using a 3-fluid nozzle
(Elsevier BV, 2018)To evaluate the feasibility of producing solid dispersions with 3-fluid nozzle spray drying to improve the dissolution behavior of lipophilic drugs, 60 experiments were performed based on a Design of Experiment. Solid ...info:eu-repo/semantics/article