Browsing Terveystieteiden tiedekunta by Title

Now showing items 536-555 of 1735

    • Elevated acute plasma miR-124-3p level relates to evolution of larger cortical lesion area after traumatic brain injury 

      Vuokila, Niina; Gupta, Shalini Das; Huusko, Riina; Tohka, Jussi; Puhakka, Noora; Pitkänen, Asla (Elsevier BV, 2020)
      Mechanisms initiated by traumatic brain injury (TBI), leading to the development of progressive secondary injury are poorly understood. MicroRNAs (miRNAs) have a proposed role in orchestrating the post-injury aftermath as ...
      Tieteelliset aikakauslehtiartikkelit

    • Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas 

      Valkonen, Mari; Haapasalo, Hannu; Rilla, Kirsi; Tyynelä-Korhonen, Kristiina; Soini, Ylermi; Pasonen-Seppänen, Sanna (Springer Nature, 2018)
      Background Diffusely infiltrating astrocytomas originate from astrocytic glial cells or their precursor cells and are the most common type of brain tumors in adults. In this retrospective study, we investigated the content ...
      Tieteelliset aikakauslehtiartikkelit

    • Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes 

      Mardinoglu A; Gogg S; Lotta LA; Stancáková A; Nerstedt A; Boren J; Blüher M; Ferrannini E; Langenberg C; Wareham NJ; Laakso M; Smith U (Elsevier BV, 2018)
      Branched-chain amino acids (BCAAs) metabolite, 3-Hydroxyisobutyric acid (3-HIB) has been identified as a secreted mediator of endothelial cell fatty acid transport and insulin resistance (IR) using animal models. To identify ...
      info:eu-repo/semantics/article

    • Elevation of tumor necrosis factor alpha levels is associated with restless legs symptoms in clinically depressed patients 

      Auvinen, Piritta; Mäntyselkä, Pekka; Koponen, Hannu; Kautiainen, Hannu Korniloff, Katariina; Ahonen, Tiina; Vanhala, Mauno (Elsevier BV, 2018)
      Background Restless legs syndrome is a sensorimotor disorder associated with several mental illnesses particularly depression. Methods A cross-sectional study of primary care patients. The prevalence of restless legs ...
      Tieteelliset aikakauslehtiartikkelit

    • Emerging Role of (Endo)Cannabinoids in Migraine 

      Leimuranta, Pinja; Khiroug, Leonard; Giniatullin, Rashid (Frontiers Media SA, 2018)
      In this mini-review, we summarize recent discoveries and present new hypotheses on the role of cannabinoids in controlling trigeminal nociceptive system underlying migraine pain. Individual sections of this review cover ...
      Tieteelliset aikakauslehtiartikkelit

    • Emerging Roles of Non-Coding RNA Transcription 

      Kaikkonen, Minna U; Adelman, Karen (Elsevier BV, 2018)
      Metazoan genomes are broadly transcribed by RNA polymerase II (RNAPII), but surprisingly few of these RNAs encode proteins. Accordingly, there is great interest in understanding the origins and potential roles of the vast ...
      Tieteelliset aikakauslehtiartikkelit

    • Endocrine effects of sauna bath 

      Huhtaniemi, IT; Laukkanen, JA (Elsevier BV, 2020)
      Sauna bath brings about numerous acute changes in hormone levels, partly akin to other stressful situations, partly specific for sauna. Norepinephrine increases in those accustomed to sauna bath. Sweating increases the ...
      Tieteelliset aikakauslehtiartikkelit

    • Endogenous cannabinoids in amygdala and hippocampus in post-mortem brains of Cloninger type 1 and 2 alcoholics 

      Kärkkäinen, Olli K; Lehtonen, Marko; Laukkanen, Virpi; Tupala, Erkki; Hyytiä, Petri; Kautiainen, Hannu; Tiihonen, Jari; Callaway, JC; Storvik, Markus (Elsevier BV, 2013)
      Accumulating evidence continues to link certain aspects of the endogenous cannabinoid (EC) system with alcohol dependence, negative-reinforcement learning, and the modulation of stress responses. Specific alterations in ...
      article

    • Endothelial cell differentiation is encompassed by changes in long range interactions between inactive chromatin regions 

      Niskanen H; Tuszynska I; Zaborowski R; Heinäniemi M; Ylä-Herttuala S; Wilczynski B; Kaikkonen MU (Oxford University Press (OUP), 2018)
      Endothelial cells (ECs) differentiate from mesodermal progenitors during vasculogenesis. By comparing changes in chromatin interactions between human umbilical vein ECs, embryonic stem cells and mesendoderm cells, we ...
      info:eu-repo/semantics/article

    • Engaging older people in an internet platform for cardiovascular risk self-management: a qualitative study among Dutch HATICE participants 

      van Middelaar, T; Beishuizen, CRL; Guillemont, J; Barbera, M; Richard, E; Moll, van Charante EP on behalf of the HATICE consortium (BMJ, 2018)
      Objectives To study older peoples’ experiences with an interactive internet platform for cardiovascular self-management, to assess which factors influence initial and sustained engagement. To assess their views on future ...
      Tieteelliset aikakauslehtiartikkelit

    • Enhanced Eating Competence Is Associated with Improved Diet Quality and Cardiometabolic Profile in Finnish Adults with Increased Risk of Type 2 Diabetes 

      Aittola, Kirsikka; Karhunen, Leila; Männikkö, Reija; Järvelä-Reijonen, Elina; Mikkonen, Santtu; Absetz, Pilvikki; Kolehmainen, Marjukka; Schwab, Ursula; Harjumaa, Marja; Lindström, Jaana; Lakka, Timo; Tilles-Tirkkonen, Tanja; Pihlajamäki, Jussi (MDPI AG, 2021)
      Eating competence (EC) is characterized by positive attitudes towards food and eating, having regular meals, eating a variety of foods, and internally regulated eating. We investigated the associations of changes in EC ...
      Tieteelliset aikakauslehtiartikkelit

    • Enhanced gene expression by a novel designed leucine zipper endosomolytic peptide 

      Ahmad, Aqeel; Rilla, Kirsi; Zou, Jing; Zhang, Weikai; Pyykkö, Ilmari; Kinnunen, Paavo; Ranjan, Sanjeev (Elsevier BV, 2021)
      An endosomal trap is a major barrier in gene therapy. We have designed an endosomolytic peptide based on the leucine zipper sequence and characterized it both structurally and functionally. The results illustrated that ...
      Tieteelliset aikakauslehtiartikkelit

    • Ennenaikainen adrenarke: yleinen, moni-ilmeinen ja hyväennusteinen kehitysvariantti 

      Liimatta, Jani; Utriainen, Pauliina; Voutilainen, Raimo; Jääskeläinen, Jarmo (Suomalainen lääkäriseura Duodecim, 2020)
      Adrenarke eli lisämunuaiskuoren kypsymisen aiheuttama "androgeeninen murrosikä" kuuluu lapsuuden normaaliin fysiologiseen kehitykseen, mutta sen perimmäistä merkitystä ei tunneta. Ennenaikainen adrenarke on liitetty ...
      Tieteelliset aikakauslehtiartikkelit

    • Enthusiastic Academic and Support Service Staff as an Agent for Change: A Case Study Based on a Project in African Higher Education Institutes 

      Haaranen, Ari; Saarti, Jarmo (Academic Conferences and Publishing International - ACPIL, 2020)
      The aim of this case study was to evaluate whether there had been educational changes and if so, in which phases of implementation and institutionalization in three African higher education institutions. The changes were ...
      Tieteelliset aikakauslehtiartikkelit

    • Environmental Correlates of Motor Competence in Children - The Skilled Kids Study 

      Niemistö, D; Finni, T; Haapala, EA; Cantell, M; Korhonen, E; Sääkslahti, A (MDPI AG, 2019)
      Environment, physical activity (PA) and motor development are tightly interwoven during childhood. We examined the associations of environmental factors with motor competence (MC) in children. Children (N = 945, 50.1% boys, ...
      Tieteelliset aikakauslehtiartikkelit

    • Environmental Intolerance, Symptoms and Disability Among Fertile-Aged Women 

      Vuokko, Aki; Karvala, Kirsi; Lampi, Jussi; Keski-Nisula, Leea; Pasanen, Markku; Voutilainen, Raimo; Pekkanen, Juha; Sainio, Markku (MDPI AG, 2018)
      The purpose was to study the prevalence of environmental intolerance (EI) and its different manifestations, including behavioral changes and disability. Fertile-aged women (n = 680) of the Kuopio Birth Cohort Study were ...
      Tieteelliset aikakauslehtiartikkelit

    • Environmental responsibility in hospital care: Findings from a qualitative study 

      Kallio, Hanna; Pietilä, Anna-Maija; Johnson, Martin; Kangasniemi, Mari (Sciedu Press, 2018)
      Objective: To identify the key elements of environmental responsibility in hospital care and the stakeholders involved. Background: Hospital care causes a significant global environmental burden, which threatens human ...
      Tieteelliset aikakauslehtiartikkelit

    • Environmental responsibility in nursing in hospitals: A modified Delphi study of nurses' views 

      Kallio, Hanna; Pietilä, Anna-Maija; Kangasniemi, Mari (Wiley, 2020)
      Objectives To identify nurses' views on environmentally responsible clinical practices, and to examine their consensus regarding the stakeholders and their roles and tools needed to promote, and enable, environmental ...
      Tieteelliset aikakauslehtiartikkelit

    • Epäsuorat altistuskokeet astman diagnosoinnissa 

      Koskela, Heikki; Tikkakoski, Antti; Karjalainen, Jussi; Mäkelä, Mika; Malmberg, Pekka (Suomalainen lääkäriseura Duodecim, 2019)
      Keuhkoputkien supistusherkkyyttä voidaan mitata epäsuorilla altistuskokeilla, mikäli astman perustutkimukset eivät varmista taudin määritystä. Astmadiagnoosiin tähtäävässä rasituskokeessa kannattaa käyttää juoksurasitusta, ...
      Tieteelliset aikakauslehtiartikkelit

    • Epävakaaseen persoonallisuuteen liittyvän psykologisen kivun ymmärtämisestä ja kohtaamisesta 

      Koivisto, Maaria; Lindeman, Sari M (Suomalainen lääkäriseura Duodecim, 2023)
      Psykologinen kipu on subjektiivinen, usein kestämättömänä koettu mielentila, jota luonnehtivat kielteinen minäkuva sekä kokemus keinottomuudesta, psykologisten tarpeiden kohtaamatta jäämisestä ja sosiaalisen yhteyden ...