Browsing Terveystieteiden tiedekunta by Title
Now showing items 583-602 of 1735
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Expression, activity and pharmacokinetic impact of ocular transporters
(Elsevier BV, 2018)The eye is protected by several tissues that limit the permeability and entry of potentially harmful substances, but also hamper the delivery of drugs in the treatment of ocular diseases. Active transport across the ocular ...Tieteelliset aikakauslehtiartikkelit
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Extended Pharmacokinetic Model of the Intravitreal Injections of Macromolecules in Rabbits. Part 2: Parameter Estimation Based on Concentration Dynamics in the Vitreous, Retina, and Aqueous Humor
(Springer Science and Business Media LLC, 2020)Purpose To estimate the diffusion coefficients of an IgG antibody (150 kDa) and its antigen-binding fragment (Fab; 50 kDa) in the neural retina (Dret) and the combined retinal pigment epithelium-choroid (DRPE-cho) with a ...Tieteelliset aikakauslehtiartikkelit
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Extended Pharmacokinetic Model of the Rabbit Eye for Intravitreal and Intracameral Injections of Macromolecules: Quantitative Analysis of Anterior and Posterior Elimination Pathways
(Springer Nature, 2018)Purpose To extend the physiological features of the anatomically accurate model of the rabbit eye for intravitreal (IVT) and intracameral (IC) injections of macromolecules. Methods The computational fluid dynamic model ...Tieteelliset aikakauslehtiartikkelit
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Extracellular ATP activates hyaluronan synthase 2 ( HAS2 ) in epidermal keratinocytes via P2Y2, Ca2+-signaling, and MAPK pathways
(Portland Press Ltd., 2018)Extracellular nucleotides are used as signaling molecules by several cell types. In epidermis, their release is triggered by insults such as ultraviolet radiation, barrier disruption, and tissue wounding, and by specific ...Tieteelliset aikakauslehtiartikkelit
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Extracellular Prolyl Oligopeptidase Derived from Activated Microglia is a Potential Neuroprotection Target
(Wiley, 2018)Prolyl oligopeptidase (PREP) is an abundant peptidase in the brain and periphery, but its physiological functions are still largely unknown. Recent findings point to a role for PREP in inflammatory processes. This study ...Tieteelliset aikakauslehtiartikkelit
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Extracellular vesicles are integral and functional components of the extracellular matrix
(Elsevier BV, 2019)Extracellular vesicles (EV) are small plasma membrane-derived particles released into the extracellular space by virtually all cell types. Recently, EV have received increased interest because of their capability to carry ...Tieteelliset aikakauslehtiartikkelit
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Eye-hand Coordination of Neurosurgeon: Evidences of Action-related Fixation in Micro-suturing
(Elsevier BV, 2021)Objective We examined performance differences between expert and novice neurosurgeons under a surgical microscope with the goal to evaluate surgical expertise. Methods The Tobii eye-tracker was used to record surgeons' ...Tieteelliset aikakauslehtiartikkelit
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Factors Associated with Anxiety and Depression among Family Caregivers of Critically Ill Elderly Patients: A Systematic Review
(Alexander Technological Educational Institute of Thessaloniki, 2022)Introduction: Family caregivers always play various tasks to support their critically ill elderly patients (CIEPs) during hospitalization. Anxiety and depression may occur among family caregivers because of the caregiving ...
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Factors associated with cervical cancer screening participation among immigrants of Russian, Somali and Kurdish origin: a population-based study in Finland
(Springer Nature, 2017)Background Previous studies revealed low participation in cervical cancer screening among immigrants compared with non-immigrants. Only a few studies about factors associated with immigrants’ lower participation rates ...info:eu-repo/semantics/article
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Factors associated with signs of temporomandibular pain: an 11-year-follow-up study on Finnish adults
(Informa UK Limited, 2020)Background: Pain in the temporomandibular region is a main complaint causing disability and distress among temporomandibular disorders sufferers. Objectives: The aim of the study was, over an 11-year follow-up on Finnish ...Tieteelliset aikakauslehtiartikkelit
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Factors associated with staying or leaving a dentist leader's position - a qualitative study
(Springer Science + Business Media, 2016)Background Leadership and leaders have important roles today, possibly even more so in the future, since major organizational changes will occur throughout the health care sector. Tomorrow’s leaders will need to be ...info:eu-repo/semantics/article
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Factors Associated With the Use of Meals-On-Wheels among Home Care Clients: The Nutormed Study
(Symbiosis Group, 2016)Background: The risk of malnutrition is quite common among home care clients. To aim of this study were to describe nutritional status of Meals-on-Wheels (MOW) clients and factors associated with use of MOW among home care ...Tieteelliset aikakauslehtiartikkelit
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Family members' expectations regarding nurses' competence in care homes: a qualitative interview study
(Wiley-Blackwell, 2018)Background Structural and cultural changes in the care of older people have influenced nursing practice, creating a need to identify current competency requirements for nurses working in care homes. Family members have ...info:eu-repo/semantics/article
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Farmakogeneettiset testit lääkehoidon tukena
(Suomalainen lääkäriseura Duodecim, 2021)Perinnölliset tekijät vaikuttavat useiden lääkehoitojen tehoon ja turvallisuuteen. Perimän on arvioitu selittävän 20-30 % poikkeavista lääkevasteista. Siten huomattava osa yksilöistä on perimänsä vuoksi pysyvästi riskiryhmässä ...Tieteelliset aikakauslehtiartikkelit
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Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function
(Springer Nature, 2017)Nonalcoholic fatty liver disease is one of the most prevalent metabolic disorders and it tightly associates with obesity, type 2 diabetes, and cardiovascular disease. Reduced mitochondrial lipid oxidation contributes to ...info:eu-repo/semantics/article
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Fast-tracking for total knee replacement reduces use of institutional care without compromising quality
(Informa UK Limited, 2018)Background and purpose — Fast-tracking shortens the length of the primary treatment period (length of stay, LOS) after total knee replacement (TKR). We evaluated the influence of the fast-track concept on the length of ...info:eu-repo/semantics/article
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Faster to First-time-in-Human: Prediction of the liquid solid ratio for continuous wet granulation
(Elsevier B.V., 2022)In early development, when active pharmaceutical ingredient (API) is in short supply, it would be beneficial to reduce the number of experiments by predicting a suitable L/S ratio before starting the product development. ...
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Fasting is not routinely required for determination of a lipid profile: clinical and laboratory implications including flagging at desirable concentration cut-points-a joint consensus statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine
(Oxford University Press (OUP), 2016)Aims To critically evaluate the clinical implications of the use of non-fasting rather than fasting lipid profiles and to provide guidance for the laboratory reporting of abnormal non-fasting or fasting lipid profiles. Methods ...info:eu-repo/semantics/article
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Fasting-Induced Transcription Factors Repress Vitamin D Bioactivation, a Mechanism for Vitamin D Deficiency in Diabetes
(American Diabetes Association, 2019)Low 25-hydroxyvitamin D levels correlate with the prevalence of diabetes; however, the mechanisms remain uncertain. Here, we show that nutritional deprivation–responsive mechanisms regulate vitamin D metabolism. Both fasting ...Tieteelliset aikakauslehtiartikkelit
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Fatal complications after an interrupted gastric bypass operation in a patient with non-alcoholic fatty liver disease and massive obesity: a case report
(Oxford University Press (OUP), 2021)Obesity is closely linked to non-alcoholic fatty liver disease and non-alcoholic steatohepatitis (NASH), the latter now being the most common cause of cirrhosis in Western countries. Only a few cases have been described, ...Tieteelliset aikakauslehtiartikkelit